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- W2754490565 abstract "The endocrine-disrupting chemical bisphenol A (BPA) increases adipose tissue mass in vivo and promotes adipogenesis in vitro; however, mechanisms explaining BPA's obesogenic effect remain unknown. We investigated the effects of gestational BPA and its analog, bisphenol S (BPS), exposure on the adipogenic differentiation ability of fetal preadipocytes and the role of endoplasmic reticulum stress in regulating this process. Pregnant sheep (n = 7 to 8 per group) mated to the same male were exposed to BPA or BPS from days 30 to 100 of gestation; pregnancies were terminated 20 days later. Adipose tissue was harvested and fetal preadipocytes isolated. Adipose tissue gene expression, adipocyte size, preadipocyte gene expression, adipogenic differentiation, and dynamic expression of genes involved in adipogenesis and endoplasmic reticulum stress were assessed. Gestational BPA enhanced adipogenic differentiation in female, but not male, preadipocytes. The unfolded protein response (UPR) pathway was upregulated in BPA-exposed female preadipocytes supportive of a higher endoplasmic reticulum stress. Increased expression of estradiol receptor 1 and glucocorticoid receptor in female preadipocytes suggests that this may be a potential cause behind the sex-specific effects observed upon BPA exposure. Gestational BPS affected adipogenic terminal differentiation gene expression in male preadipocytes, but not adipogenic differentiation potential. We demonstrate that gestational BPA exposure can modulate the differentiation ability of fetal preadipocytes. UPR upregulation in gestationally BPA-exposed female preadipocytes may contribute to the increased preadipocyte's adipogenic ability. The marked sex-specific effect of BPA highlights higher susceptibility of females to bisphenol A and potentially, a higher risk to develop obesity in adulthood." @default.
- W2754490565 created "2017-09-25" @default.
- W2754490565 creator A5030663064 @default.
- W2754490565 creator A5052065231 @default.
- W2754490565 creator A5064864858 @default.
- W2754490565 creator A5065285661 @default.
- W2754490565 date "2017-09-14" @default.
- W2754490565 modified "2023-10-18" @default.
- W2754490565 title "Sex-Specific Modulation of Fetal Adipogenesis by Gestational Bisphenol A and Bisphenol S Exposure" @default.
- W2754490565 cites W1492870075 @default.
- W2754490565 cites W1651776210 @default.
- W2754490565 cites W1832924936 @default.
- W2754490565 cites W1969191244 @default.
- W2754490565 cites W1974435147 @default.
- W2754490565 cites W1976319789 @default.
- W2754490565 cites W1982040808 @default.
- W2754490565 cites W1989020172 @default.
- W2754490565 cites W1992386938 @default.
- W2754490565 cites W1996661765 @default.
- W2754490565 cites W1997569605 @default.
- W2754490565 cites W2004160084 @default.
- W2754490565 cites W2005307515 @default.
- W2754490565 cites W2007078899 @default.
- W2754490565 cites W2007586461 @default.
- W2754490565 cites W2007980175 @default.
- W2754490565 cites W2009910589 @default.
- W2754490565 cites W2010198992 @default.
- W2754490565 cites W2015008373 @default.
- W2754490565 cites W2016701686 @default.
- W2754490565 cites W2017707375 @default.
- W2754490565 cites W2018115529 @default.
- W2754490565 cites W2018910489 @default.
- W2754490565 cites W2019920753 @default.
- W2754490565 cites W2019958103 @default.
- W2754490565 cites W2020844131 @default.
- W2754490565 cites W2021394740 @default.
- W2754490565 cites W2024201289 @default.
- W2754490565 cites W2025811822 @default.
- W2754490565 cites W2027438949 @default.
- W2754490565 cites W2028122319 @default.
- W2754490565 cites W2029557283 @default.
- W2754490565 cites W2045059986 @default.
- W2754490565 cites W2046176216 @default.
- W2754490565 cites W2046397137 @default.
- W2754490565 cites W2049069390 @default.
- W2754490565 cites W2049110564 @default.
- W2754490565 cites W2053570362 @default.
- W2754490565 cites W2056129497 @default.
- W2754490565 cites W2061510535 @default.
- W2754490565 cites W2067082060 @default.
- W2754490565 cites W2069684137 @default.
- W2754490565 cites W2070235997 @default.
- W2754490565 cites W2078483069 @default.
- W2754490565 cites W2084444116 @default.
- W2754490565 cites W2089523163 @default.
- W2754490565 cites W2090637770 @default.
- W2754490565 cites W2094088441 @default.
- W2754490565 cites W2097526790 @default.
- W2754490565 cites W2101969083 @default.
- W2754490565 cites W2104276917 @default.
- W2754490565 cites W2105005092 @default.
- W2754490565 cites W2106229125 @default.
- W2754490565 cites W2108187293 @default.
- W2754490565 cites W2113576333 @default.
- W2754490565 cites W2114570899 @default.
- W2754490565 cites W2129160382 @default.
- W2754490565 cites W2130156907 @default.
- W2754490565 cites W2131363228 @default.
- W2754490565 cites W2135301154 @default.
- W2754490565 cites W2139245414 @default.
- W2754490565 cites W2144313139 @default.
- W2754490565 cites W2144573094 @default.
- W2754490565 cites W2149120265 @default.
- W2754490565 cites W2152698697 @default.
- W2754490565 cites W2166064032 @default.
- W2754490565 cites W2167279371 @default.
- W2754490565 cites W2171338004 @default.
- W2754490565 cites W2187386684 @default.
- W2754490565 cites W2252869040 @default.
- W2754490565 cites W2265563112 @default.
- W2754490565 cites W2268703375 @default.
- W2754490565 cites W2289069921 @default.
- W2754490565 cites W2296046760 @default.
- W2754490565 cites W2297202934 @default.
- W2754490565 cites W2309158892 @default.
- W2754490565 cites W2323902431 @default.
- W2754490565 cites W2403186208 @default.
- W2754490565 cites W2409759722 @default.
- W2754490565 cites W2413758691 @default.
- W2754490565 cites W2467692369 @default.
- W2754490565 cites W2470954218 @default.
- W2754490565 cites W2485966548 @default.
- W2754490565 cites W2502880101 @default.
- W2754490565 cites W2537546128 @default.
- W2754490565 cites W2549632864 @default.
- W2754490565 cites W2569505713 @default.
- W2754490565 cites W2570883978 @default.
- W2754490565 cites W2581677000 @default.