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- W2754552369 abstract "An efficient Pd(0)-catalyzed synthesis of 2-cyanoindoles from 2-gem-dihalovinylanilines is reported. Few methods have aimed to synthesize these scaffolds, which are found in many natural products and have high bioactivity. This protocol features a robust catalyst system utilizing Zn(TFA)2 to prolong the catalytic activity. Additionally, the amount of cyanide in the reaction phase is minimized by taking advantage of the solubility of Zn(CN)2 in a two-solvent mixture." @default.
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- W2754552369 date "2017-09-13" @default.
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- W2754552369 title "Palladium-Catalyzed Synthesis of 2-Cyanoindoles from 2-<i>gem</i>-Dihalovinylanilines" @default.
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- W2754552369 doi "https://doi.org/10.1021/acs.orglett.7b02244" @default.
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