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- W2754564504 endingPage "301" @default.
- W2754564504 startingPage "292" @default.
- W2754564504 abstract "Most, if not all, human cancers exhibit altered epigenetic signatures that promote aberrant gene expression that contributes to cellular transformation. Historically, attempts to pharmacologically intervene in this process have focused on DNA methylation and histone acetylation. More recently, genome-wide studies have identified histone and chromatin regulators as one of the most frequently dysregulated functional classes in a wide range of cancer types. These findings have provided numerous potential therapeutic targets including many that affect histone methylation. These include histone lysine methyltransferases such as enhancer of zeste homolog 2 and DOT1L, protein arginine methyltransferases such as protein arginine methyltransferase 5, and histone lysine demethylases such as lysine-specific demethylase 1. This review presents the rationale for targeting histone methylation in oncology and provides an update on a few key targets that are being investigated in the clinic." @default.
- W2754564504 created "2017-09-25" @default.
- W2754564504 creator A5039169226 @default.
- W2754564504 creator A5069540994 @default.
- W2754564504 creator A5088240960 @default.
- W2754564504 creator A5089075163 @default.
- W2754564504 date "2017-09-01" @default.
- W2754564504 modified "2023-10-14" @default.
- W2754564504 title "Targeting Histone Methylation in Cancer" @default.
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