FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2754569863> ?p ?o ?g. }

• W2754569863 endingPage "407" @default.
• W2754569863 startingPage "394" @default.
• W2754569863 abstract "Purpose: Radiotherapy (RT) is a mainstay in the treatment of solid tumors and works by inducing free radical stress in tumor cells, leading to loss of reproductive integrity. The optimal treatment strategy has to consider damage to both tumor and normal cells and is determined by five factors known as the 5 R’s of radiobiology: Reoxygenation, DNA repair, radiosensitivity, redistribution in the cell cycle and repopulation. The aim of this review is (i) to present evidence that these 5 R’s are strongly influenced by cellular and whole-body metabolism that in turn can be modified through ketogenic therapy in form of ketogenic diets and short-term fasting and (ii) to stimulate new research into this field including some research questions deserving further study.Conclusions: Preclinical and some preliminary clinical data support the hypothesis that ketogenic therapy could be utilized as a complementary treatment in order to improve the outcome after RT, both in terms of higher tumor control and in terms of lower normal tissue complication probability. The first effect relates to the metabolic shift from glycolysis toward mitochondrial metabolism that selectively increases ROS production and impairs ATP production in tumor cells. The second effect is based on the differential stress resistance phenomenon, which is achieved when glucose and growth factors are reduced and ketone bodies are elevated, reprogramming normal but not tumor cells from proliferation toward maintenance and stress resistance. Underlying both effects are metabolic differences between normal and tumor cells that ketogenic therapy seeks to exploit. Specifically, the recently discovered role of the ketone body β-hydroxybutyrate as an endogenous class-I histone deacetylase inhibitor suggests a dual role as a radioprotector of normal cells and a radiosensitzer of tumor cells that opens up exciting possibilities to employ ketogenic therapy as a cost-effective adjunct to radiotherapy against cancer." @default.
• W2754569863 created "2017-09-25" @default.
• W2754569863 creator A5064617606 @default.
• W2754569863 date "2017-10-09" @default.
• W2754569863 modified "2023-10-17" @default.
• W2754569863 title "The influence of ketogenic therapy on the 5 R’s of radiobiology" @default.
• W2754569863 cites W1493806409 @default.
• W2754569863 cites W1495798500 @default.
• W2754569863 cites W1507458768 @default.
• W2754569863 cites W1510071269 @default.
• W2754569863 cites W1536741467 @default.
• W2754569863 cites W1650754258 @default.
• W2754569863 cites W1653443644 @default.
• W2754569863 cites W1825922607 @default.
• W2754569863 cites W1866746139 @default.
• W2754569863 cites W1868131768 @default.
• W2754569863 cites W1909101199 @default.
• W2754569863 cites W1964463784 @default.
• W2754569863 cites W1965979340 @default.
• W2754569863 cites W1971160716 @default.
• W2754569863 cites W1972868246 @default.
• W2754569863 cites W1975090760 @default.
• W2754569863 cites W1975289931 @default.
• W2754569863 cites W1976886354 @default.
• W2754569863 cites W1980947442 @default.
• W2754569863 cites W1981968676 @default.
• W2754569863 cites W1983017460 @default.
• W2754569863 cites W1984266465 @default.
• W2754569863 cites W1987238295 @default.
• W2754569863 cites W1988627015 @default.
• W2754569863 cites W1989888708 @default.
• W2754569863 cites W1991006545 @default.
• W2754569863 cites W1992887184 @default.
• W2754569863 cites W1993906477 @default.
• W2754569863 cites W1994449816 @default.
• W2754569863 cites W1994687037 @default.
• W2754569863 cites W1996020104 @default.
• W2754569863 cites W1998997961 @default.
• W2754569863 cites W2003157929 @default.
• W2754569863 cites W2007416032 @default.
• W2754569863 cites W2008575388 @default.
• W2754569863 cites W2011662441 @default.
• W2754569863 cites W2014619819 @default.
• W2754569863 cites W2022743487 @default.
• W2754569863 cites W2032533550 @default.
• W2754569863 cites W2035258932 @default.
• W2754569863 cites W2035560215 @default.
• W2754569863 cites W2036551825 @default.
• W2754569863 cites W2053527204 @default.
• W2754569863 cites W2054501491 @default.
• W2754569863 cites W2057247058 @default.
• W2754569863 cites W2057300452 @default.
• W2754569863 cites W2057909622 @default.
• W2754569863 cites W2058257534 @default.
• W2754569863 cites W2058547466 @default.
• W2754569863 cites W2058850076 @default.
• W2754569863 cites W2062915487 @default.
• W2754569863 cites W2063509147 @default.
• W2754569863 cites W2063623394 @default.
• W2754569863 cites W2067133158 @default.
• W2754569863 cites W2072451938 @default.
• W2754569863 cites W2074343204 @default.
• W2754569863 cites W2075670373 @default.
• W2754569863 cites W2075905368 @default.
• W2754569863 cites W2076908467 @default.
• W2754569863 cites W2078192821 @default.
• W2754569863 cites W2083741341 @default.
• W2754569863 cites W2089057393 @default.
• W2754569863 cites W2093289166 @default.
• W2754569863 cites W2098358937 @default.
• W2754569863 cites W2098964938 @default.
• W2754569863 cites W2100385704 @default.
• W2754569863 cites W2102955022 @default.
• W2754569863 cites W2103147617 @default.
• W2754569863 cites W2103953491 @default.
• W2754569863 cites W2104035332 @default.
• W2754569863 cites W2106840901 @default.
• W2754569863 cites W2110411886 @default.
• W2754569863 cites W2111253773 @default.
• W2754569863 cites W2111432414 @default.
• W2754569863 cites W2115094712 @default.
• W2754569863 cites W2116304731 @default.
• W2754569863 cites W2116408939 @default.
• W2754569863 cites W2116478273 @default.
• W2754569863 cites W2116974984 @default.
• W2754569863 cites W2118980450 @default.
• W2754569863 cites W2120600243 @default.
• W2754569863 cites W2121141922 @default.
• W2754569863 cites W2123244357 @default.
• W2754569863 cites W2123757256 @default.
• W2754569863 cites W2124361666 @default.
• W2754569863 cites W2127527009 @default.
• W2754569863 cites W2131746764 @default.
• W2754569863 cites W2133032371 @default.
• W2754569863 cites W2136503478 @default.
• W2754569863 cites W2139246522 @default.
• W2754569863 cites W2139271329 @default.
• W2754569863 cites W2139737156 @default.

• next