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- W2754583650 abstract "Genetic epidemiology focuses on the study of interaction between genetic components of disease and effect of environment on the phenotype. Our study uses retrospective analyses in order to show the incidence frequencies and risk factors which influence epidemiology of lung cancer. The analysis of lung cancer incidence was carried out on different regions in Croatia. According to State Register data and our own research results the incidence in males has risen from 49.3 to 89.4/100.000 and in females from 7.1 to 16.2/100.000 in the period 1968-1991. The highest rate has been recorded in industrialized regions (Koprivnica - Križevci 63.8; Međimurje 63.3; Krapina -Zagorje 62.8/100.000). Although we know that environmental factors (smoking, air pollution etc.) play important role in lung cancer development; the instability of genes make possible high incidence of the disease even in the regions without pronounced risk factors (Istra 50.4; Dubrovnik 43.4). The instability of genes is predominantly caused by accumulation of somatic genetic changes, and is also dependent on heterogeneity of population. This study demands the connection between population and clinical-genetic studies, which will enable better understanding of etiology and etiopathogenesis of this disease." @default.
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- W2754583650 date "1998-01-01" @default.
- W2754583650 modified "2023-09-22" @default.
- W2754583650 title "The Lung Cancer Incidence in Population of Croatia" @default.
- W2754583650 hasPublicationYear "1998" @default.
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