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• W2754644807 abstract "Asthma is characterized by episodic, reversible airflow obstruction associated with variable levels of inflammation. Over the past several decades, there has been an increasing appreciation that the clinical presentation of asthma comprises a diverse set of underlying pathologies. Rather than being viewed as a single disease entity asthma is now thought of as a clinical syndrome with the involvement of multiple pathological mechanisms. While it is appreciated that eosinophilia is present in only a subset of patients it remains a key feature of asthma and other eosinophilic disorders such as atopic dermatitis, eosinophilic esophagitis, and chronic rhinosinusitis with nasal polyps. Eosinophils are bone marrow derived leukocytes present in low numbers in health; however, during disease the type 2 cytokines (interleukins (IL)-4, -5 and -13) can induce rapid eosinophilopoiesis, prolonged eosinophil survival and trafficking to the site of injury. In diseases such as allergic asthma there is an aberrant inflammatory response leading to eosinophilia, tissue damage and airway pathology. IL-13 is a pleiotropic type 2 cytokine that has been shown to be integral in the pathogenesis of asthma and other eosinophilic disorders. IL-13 levels are elevated in animal models of eosinophilic inflammation and in the blood and tissue of patients diagnosed with eosinophilic disorders. IL-13 signaling elicits many pathogenic mechanisms including the promotion of eosinophil survival, activation and trafficking. Data from preclinical models and clinical trials of IL-13 inhibitors in patients have revealed mechanistic insights into the role of this cytokine in driving eosinophilia. Promising results from clinical trials further support a key mechanistic role of IL-13 in asthma and other eosinophilic disorders. Here, we provide a perspective on the role of IL-13 in asthma and other eosinophilic disorders and describe ongoing clinical trials targeting this pathway in patients with significant unmet medical needs." @default.
• W2754644807 created "2017-09-25" @default.
• W2754644807 creator A5036199727 @default.
• W2754644807 creator A5043314377 @default.
• W2754644807 creator A5050810572 @default.
• W2754644807 creator A5062001477 @default.
• W2754644807 creator A5079491232 @default.
• W2754644807 creator A5086286603 @default.
• W2754644807 date "2017-09-19" @default.
• W2754644807 modified "2023-10-11" @default.
• W2754644807 title "Interleukin-13 in Asthma and Other Eosinophilic Disorders" @default.
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