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• W2754691818 endingPage "787" @default.
• W2754691818 startingPage "781" @default.
• W2754691818 abstract "Pattern-recognition receptors (PRRs) are expressed by innate immune cells and recognize pathogen-associated molecular patterns (PAMPs) as well as endogenous damage-associated molecular pattern (DAMP) molecules. With a large potential for synergism or convergence between their signaling pathways, PRRs orchestrate a complex interplay of cellular mediators and transcription factors, and thus play a central role in homeostasis and host defense. Aberrant activation of PRR signaling, mutations of the receptors and/or their downstream signaling molecules, and/or DAMP/PAMP complex–mediated receptor signaling can potentially lead to chronic auto-inflammatory diseases or development of cancer. PRR signaling pathways appear to also present an interesting new avenue for the modulation of inflammatory responses and to serve as potential novel therapeutic targets. Evidence for a dysregulation of the PRR toll-like receptor (TLR)2, TLR4, TLR5, and TLR9, nucleotide-binding oligomerization domain–containing protein (NOD)2, and the receptor of advanced glycation end products (RAGE) exists in dogs with chronic enteropathies. We describe the TLR, NOD2, and RAGE signaling pathways and evaluate the current veterinary literature—in comparison to human medicine—to determine the role of TLRs, NOD2, and RAGE in canine chronic enteropathies." @default.
• W2754691818 created "2017-09-25" @default.
• W2754691818 creator A5018799234 @default.
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• W2754691818 date "2017-09-14" @default.
• W2754691818 modified "2023-10-18" @default.
• W2754691818 title "Pattern-recognition receptors: signaling pathways and dysregulation in canine chronic enteropathies—brief review" @default.
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• W2754691818 doi "https://doi.org/10.1177/1040638717728545" @default.
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• W2754691818 hasPublicationYear "2017" @default.
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