Matches in SemOpenAlex for { <https://semopenalex.org/work/W2754750157> ?p ?o ?g. }
- W2754750157 endingPage "1854" @default.
- W2754750157 startingPage "1835" @default.
- W2754750157 abstract "The emergence of a multitarget design approach in the development of new potential anti-Alzheimer's disease agents has resulted in the discovery of many multifunctional compounds focusing on various targets. Among them the largest group comprises inhibitors of both cholinesterases, with additional anti-β-amyloid aggregation activity. This review describes recent advances in this research area and presents the most interesting compounds reported over a 2-year span (2015–2016). The majority of hybrids possess heterodimeric structures obtained by linking structurally active fragments interacting with different targets. Multipotent cholinesterase inhibitors with β-amyloid antiaggregating activity may additionally possess antioxidative, neuroprotective or metal-chelating properties or less common features such as anti-β-secretase or τ-antiaggregation activity." @default.
- W2754750157 created "2017-09-25" @default.
- W2754750157 creator A5012679594 @default.
- W2754750157 creator A5021066876 @default.
- W2754750157 creator A5027452914 @default.
- W2754750157 creator A5076818213 @default.
- W2754750157 creator A5090381376 @default.
- W2754750157 date "2017-10-01" @default.
- W2754750157 modified "2023-10-14" @default.
- W2754750157 title "Advances toward multifunctional cholinesterase and β-amyloid aggregation inhibitors" @default.
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