Matches in SemOpenAlex for { <https://semopenalex.org/work/W2754785305> ?p ?o ?g. }
- W2754785305 abstract "Abstract The absence of an adequate reversal strategy to prevent and stop potential life-threatening bleeding complications is a major drawback to the clinical use of the direct oral inhibitors of blood coagulation factor Xa. Here we show that specific modifications of the substrate-binding aromatic S4 subpocket within the factor Xa active site disrupt high-affinity engagement of the direct factor Xa inhibitors. These modifications either entail amino-acid substitution of S4 subsite residues Tyr99 and/or Phe174 (chymotrypsinogen numbering), or extension of the 99-loop that borders the S4 subsite. The latter modifications led to the engineering of a factor Xa variant that is able to support coagulation in human plasma spiked with (supra-)physiological concentrations of direct factor Xa inhibitors. As such, this factor Xa variant has the potential to be employed to bypass the direct factor Xa inhibitor-mediated anticoagulation in patients that require restoration of blood coagulation." @default.
- W2754785305 created "2017-09-25" @default.
- W2754785305 creator A5001597659 @default.
- W2754785305 creator A5006767372 @default.
- W2754785305 creator A5016524733 @default.
- W2754785305 creator A5022230505 @default.
- W2754785305 creator A5029792587 @default.
- W2754785305 creator A5048911632 @default.
- W2754785305 creator A5057396192 @default.
- W2754785305 date "2017-09-13" @default.
- W2754785305 modified "2023-09-27" @default.
- W2754785305 title "Engineered factor Xa variants retain procoagulant activity independent of direct factor Xa inhibitors" @default.
- W2754785305 cites W1031578623 @default.
- W2754785305 cites W1542609899 @default.
- W2754785305 cites W1568662837 @default.
- W2754785305 cites W1639651656 @default.
- W2754785305 cites W1833880006 @default.
- W2754785305 cites W1964694893 @default.
- W2754785305 cites W1970342224 @default.
- W2754785305 cites W1974063447 @default.
- W2754785305 cites W1974514823 @default.
- W2754785305 cites W1980009210 @default.
- W2754785305 cites W1982196959 @default.
- W2754785305 cites W1988437166 @default.
- W2754785305 cites W1994568170 @default.
- W2754785305 cites W1995113091 @default.
- W2754785305 cites W1995402271 @default.
- W2754785305 cites W1995816895 @default.
- W2754785305 cites W1995886976 @default.
- W2754785305 cites W1997848365 @default.
- W2754785305 cites W1998756228 @default.
- W2754785305 cites W2002635586 @default.
- W2754785305 cites W2002893321 @default.
- W2754785305 cites W2004470519 @default.
- W2754785305 cites W2005368084 @default.
- W2754785305 cites W2006053652 @default.
- W2754785305 cites W2011706759 @default.
- W2754785305 cites W2013050330 @default.
- W2754785305 cites W2015772062 @default.
- W2754785305 cites W2024599256 @default.
- W2754785305 cites W2024641847 @default.
- W2754785305 cites W2028799498 @default.
- W2754785305 cites W2031517046 @default.
- W2754785305 cites W2032901672 @default.
- W2754785305 cites W2035266068 @default.
- W2754785305 cites W2037420431 @default.
- W2754785305 cites W2038722284 @default.
- W2754785305 cites W2051906491 @default.
- W2754785305 cites W2056137443 @default.
- W2754785305 cites W2057477511 @default.
- W2754785305 cites W2064388657 @default.
- W2754785305 cites W2075590106 @default.
- W2754785305 cites W2079487514 @default.
- W2754785305 cites W2093049209 @default.
- W2754785305 cites W2093118249 @default.
- W2754785305 cites W2099476014 @default.
- W2754785305 cites W2103573619 @default.
- W2754785305 cites W2107361996 @default.
- W2754785305 cites W2112319570 @default.
- W2754785305 cites W2113285433 @default.
- W2754785305 cites W2119768870 @default.
- W2754785305 cites W2122976061 @default.
- W2754785305 cites W2128572087 @default.
- W2754785305 cites W2132987695 @default.
- W2754785305 cites W2153423854 @default.
- W2754785305 cites W2159011905 @default.
- W2754785305 cites W2170327826 @default.
- W2754785305 cites W2218756848 @default.
- W2754785305 cites W2480311966 @default.
- W2754785305 cites W2492725532 @default.
- W2754785305 cites W2553572012 @default.
- W2754785305 cites W410189575 @default.
- W2754785305 cites W62994428 @default.
- W2754785305 doi "https://doi.org/10.1038/s41467-017-00647-9" @default.
- W2754785305 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5597622" @default.
- W2754785305 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28904343" @default.
- W2754785305 hasPublicationYear "2017" @default.
- W2754785305 type Work @default.
- W2754785305 sameAs 2754785305 @default.
- W2754785305 citedByCount "24" @default.
- W2754785305 countsByYear W27547853052018 @default.
- W2754785305 countsByYear W27547853052019 @default.
- W2754785305 countsByYear W27547853052020 @default.
- W2754785305 countsByYear W27547853052021 @default.
- W2754785305 countsByYear W27547853052022 @default.
- W2754785305 countsByYear W27547853052023 @default.
- W2754785305 crossrefType "journal-article" @default.
- W2754785305 hasAuthorship W2754785305A5001597659 @default.
- W2754785305 hasAuthorship W2754785305A5006767372 @default.
- W2754785305 hasAuthorship W2754785305A5016524733 @default.
- W2754785305 hasAuthorship W2754785305A5022230505 @default.
- W2754785305 hasAuthorship W2754785305A5029792587 @default.
- W2754785305 hasAuthorship W2754785305A5048911632 @default.
- W2754785305 hasAuthorship W2754785305A5057396192 @default.
- W2754785305 hasBestOaLocation W27547853051 @default.
- W2754785305 hasConcept C126322002 @default.
- W2754785305 hasConcept C185592680 @default.
- W2754785305 hasConcept C203014093 @default.
- W2754785305 hasConcept C2777292125 @default.
- W2754785305 hasConcept C2777444498 @default.