FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2754832015> ?p ?o ?g. }

• W2754832015 endingPage "534" @default.
• W2754832015 startingPage "525" @default.
• W2754832015 abstract "Obesity is a metabolic disorder that predisposes patients to numerous diseases and has become a major global public-health concern. Animal models of diet-induced obesity (DIO) are frequently used to study obesity, but which DIO model most accurately reflects the pathology of human obesity remains unclear. In this study, we designed a diet based on the human Western diet (WD) and compared it with the cafeteria diet (CAF) and high-fat diet (HFD) in order to evaluate which diet most closely mirrors human obesity. Wistar rats were fed four different diets (WD, CAF, HFD and a low-fat diet) for 18 weeks. Metabolic parameters and gut microbiota changes were then characterized. Rats fed the four different diets exhibited completely different phenotypes, highlighting the importance of diet selection. This study also revealed that WD most effectively induced obesity and obesity-related disorders, and thus proved to be a robust model of human obesity. Moreover, WD-fed rats developed obesity and obesity-related comorbidities independent of major alterations in gut microbiota composition (dysbiosis), whereas CAF-fed rats developed the greatest dysbiosis independent of obesity. We also characterized gut microbiota after feeding on these four different diets and identified five genera that might be involved in the pathogenesis of obesity. These data suggest that diet, and not the obese state, was the major driving force behind gut microbiota changes. Moreover, the marked dysbiosis observed in CAF-fed rats might have resulted from the presence of several additives present in the CAF diet, or even a lack of essential vitamins and minerals. Based on our findings, we recommend the use of the prototypic WD (designed here) in DIO models. Conversely, CAF could be used to investigate the effects of excessive consumption of industrially produced and highly processed foods, which are characteristic of Western society." @default.
• W2754832015 created "2017-09-25" @default.
• W2754832015 creator A5008635046 @default.
• W2754832015 creator A5010969509 @default.
• W2754832015 creator A5018877036 @default.
• W2754832015 creator A5025153499 @default.
• W2754832015 creator A5028563854 @default.
• W2754832015 creator A5034419483 @default.
• W2754832015 creator A5054545041 @default.
• W2754832015 creator A5068876022 @default.
• W2754832015 creator A5074270215 @default.
• W2754832015 creator A5088853716 @default.
• W2754832015 date "2017-09-12" @default.
• W2754832015 modified "2023-10-14" @default.
• W2754832015 title "A new animal diet based on human Western diet is a robust diet-induced obesity model: comparison to high-fat and cafeteria diets in term of metabolic and gut microbiota disruption" @default.
• W2754832015 cites W1579591484 @default.
• W2754832015 cites W1831301545 @default.
• W2754832015 cites W1968105193 @default.
• W2754832015 cites W1971297175 @default.
• W2754832015 cites W1978966909 @default.
• W2754832015 cites W1982703569 @default.
• W2754832015 cites W1995762183 @default.
• W2754832015 cites W2004549986 @default.
• W2754832015 cites W2005910960 @default.
• W2754832015 cites W2008697716 @default.
• W2754832015 cites W2008993230 @default.
• W2754832015 cites W2027547437 @default.
• W2754832015 cites W2030999674 @default.
• W2754832015 cites W2033516665 @default.
• W2754832015 cites W2036047239 @default.
• W2754832015 cites W2038217946 @default.
• W2754832015 cites W2039663505 @default.
• W2754832015 cites W2048060485 @default.
• W2754832015 cites W2053769775 @default.
• W2754832015 cites W2088940658 @default.
• W2754832015 cites W2107267410 @default.
• W2754832015 cites W2110999037 @default.
• W2754832015 cites W2114270323 @default.
• W2754832015 cites W2137068383 @default.
• W2754832015 cites W2146661415 @default.
• W2754832015 cites W2149515881 @default.
• W2754832015 cites W2155709875 @default.
• W2754832015 cites W2157339128 @default.
• W2754832015 cites W2165546996 @default.
• W2754832015 cites W2168162793 @default.
• W2754832015 cites W2168553115 @default.
• W2754832015 cites W2273697418 @default.
• W2754832015 cites W2308906685 @default.
• W2754832015 cites W2337372962 @default.
• W2754832015 cites W2339765445 @default.
• W2754832015 cites W2465534016 @default.
• W2754832015 cites W2511123674 @default.
• W2754832015 cites W2516927384 @default.
• W2754832015 cites W4211007940 @default.
• W2754832015 cites W4252803189 @default.
• W2754832015 doi "https://doi.org/10.1038/ijo.2017.225" @default.
• W2754832015 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28895587" @default.
• W2754832015 hasPublicationYear "2017" @default.
• W2754832015 type Work @default.
• W2754832015 sameAs 2754832015 @default.
• W2754832015 citedByCount "137" @default.
• W2754832015 countsByYear W27548320152018 @default.
• W2754832015 countsByYear W27548320152019 @default.
• W2754832015 countsByYear W27548320152020 @default.
• W2754832015 countsByYear W27548320152021 @default.
• W2754832015 countsByYear W27548320152022 @default.
• W2754832015 countsByYear W27548320152023 @default.
• W2754832015 crossrefType "journal-article" @default.
• W2754832015 hasAuthorship W2754832015A5008635046 @default.
• W2754832015 hasAuthorship W2754832015A5010969509 @default.
• W2754832015 hasAuthorship W2754832015A5018877036 @default.
• W2754832015 hasAuthorship W2754832015A5025153499 @default.
• W2754832015 hasAuthorship W2754832015A5028563854 @default.
• W2754832015 hasAuthorship W2754832015A5034419483 @default.
• W2754832015 hasAuthorship W2754832015A5054545041 @default.
• W2754832015 hasAuthorship W2754832015A5068876022 @default.
• W2754832015 hasAuthorship W2754832015A5074270215 @default.
• W2754832015 hasAuthorship W2754832015A5088853716 @default.
• W2754832015 hasBestOaLocation W27548320152 @default.
• W2754832015 hasConcept C126322002 @default.
• W2754832015 hasConcept C134018914 @default.
• W2754832015 hasConcept C142724271 @default.
• W2754832015 hasConcept C203014093 @default.
• W2754832015 hasConcept C2777165150 @default.
• W2754832015 hasConcept C2780509477 @default.
• W2754832015 hasConcept C2780578515 @default.
• W2754832015 hasConcept C3019468659 @default.
• W2754832015 hasConcept C42407357 @default.
• W2754832015 hasConcept C511355011 @default.
• W2754832015 hasConcept C539455810 @default.
• W2754832015 hasConcept C71924100 @default.
• W2754832015 hasConcept C86803240 @default.
• W2754832015 hasConceptScore W2754832015C126322002 @default.
• W2754832015 hasConceptScore W2754832015C134018914 @default.
• W2754832015 hasConceptScore W2754832015C142724271 @default.
• W2754832015 hasConceptScore W2754832015C203014093 @default.
• W2754832015 hasConceptScore W2754832015C2777165150 @default.
• W2754832015 hasConceptScore W2754832015C2780509477 @default.

• next