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• W2754981928 abstract "The performance of mechanical work by isolated cardiac muscle samples has typically been studied by subjecting their tissues to an isotonic shortening protocol, which results in flat-topped work-loop profiles. In order to better replicate the forces experienced by these tissues in vivo, we have developed a system for imposing a model-based, time-varying, load on isolated cardiac tissue preparations. A model of systemic afterload was developed from the combination of a Windkessel-type model of vascular fluid impedance, and the Laplace law of the heart, and encoded into a hardware-based control system. The model-predicted length change was then imposed on an isolated cardiac trabecula in a work-loop calorimeter, giving rise to force-length work-loops that more closely resemble those experienced by these tissues in vivo." @default.
• W2754981928 created "2017-09-25" @default.
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• W2754981928 date "2017-07-01" @default.
• W2754981928 modified "2023-09-25" @default.
• W2754981928 title "Real-time model-based control of afterload for in vitro cardiac tissue experimentation" @default.
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• W2754981928 doi "https://doi.org/10.1109/embc.2017.8037067" @default.
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