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• W2755009720 abstract "// Qingtao Meng 1, * , Shizhi Wang 1, * , Weiyan Tang 2, * , Shenshen Wu 1 , Na Gao 3 , Chengcheng Zhang 1 , Xiaoli Cao 4 , Xiaobo Li 1 , Zhengdong Zhang 5 , Michael Aschner 6 , Hua Jin 7, ** , Yue Huang 8, ** and Rui Chen 1, 9, ** 1 Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing, China 2 Medical Oncology, Jiangsu Cancer Hospital, Nanjing, China 3 Institute of Bioinformatics, Heinrich Heine University, Düsseldorf, Germany 4 Clinical Lab, Nantong Tumor Hospital, Nantong, China 5 Department of Environmental Genomics, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Nanjing Medical University, Nanjing, China 6 Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, USA 7 Core Laboratory, Nantong Tumor Hospital, Nantong, China 8 Department of Pathology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China 9 State Key Laboratory of Respiratory Disease, Institute for Chemical Carcinogenesis, Guangzhou Medical University, Guangzhou, China * These authors have contributed equally to this work ** These authors co-supervised this work Correspondence to: Rui Chen, email: 101011816@seu.edu.cn Yue Huang, email: redxxy@163.com Hua Jin, email: ntmgjh@163.com Keywords: base excision repair, XRCC1, cervical cancer, Krox-20, specificity protein 1 Received: June 29, 2017      Accepted: August 09, 2017      Published: September 16, 2017 ABSTRACT Cervical cancer is the second leading cause of mortality among women. Impairment of the base excision repair (BER) pathway is one of the major causes of the initiation and progression of cervical cancer. However, whether the polymorphisms of the BER pathway components (i.e., HOGG1, XRCC1, ADPRT , and APE1 ) can affect the risk of cervical cancer remains unknown. Herein, we applied a hospital-based case-control study covering two independent cohorts and a subsequent functional assay to determine the roles of the single nucleotide polymorphisms (SNPs) of the BER pathway genes in cervical cancer. Results indicated that the XRCC1 rs3213245 (-77TC) TT genotype was associated with an increased risk of cervical cancer. The immunohistochemistry assay showed that XRCC1 protein expression levels were upregulated in cervical cancer patients with the XRCC1 rs3213245 CC genotype compared with the CT or TT genotypes. Further, results from ChIP assay showed that Sp1 could bind to the −77 site and that the rs3213245 C genotype promoted the binding of Sp1 to the XRCC1 promoter. Moreover, ChIP/Re-ChIP assays revealed that transcription factor Krox-20 was recruited to the XRCC1 rs3213245 mutation region and regulated the transcription of the XRCC1 gene by interacting with Sp1, ultimately mediated cervical cancer development. In summary, the findings indicated that the functional XRCC1 SNP rs3213245 was associated with the risk of cervical cancer based on the Sp1/Krox-20 switch." @default.
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• W2755009720 date "2017-09-16" @default.
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• W2755009720 title "XRCC1 mediated the development of cervival cancer through a novel Sp1/Krox-20 swich" @default.
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• W2755009720 doi "https://doi.org/10.18632/oncotarget.21040" @default.
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