FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2755015722> ?p ?o ?g. }

• W2755015722 abstract "Recent evidence has established a role for the small GTPase RAB25, as well as related effector proteins, in enacting both pro-oncogenic and anti-oncogenic phenotypes in specific cellular contexts. Here we report the development of all-hydrocarbon stabilized peptides derived from the RAB-binding FIP-family of proteins to target RAB25. Relative to unmodified peptides, optimized stapled peptides exhibit increased structural stability, binding affinity, cell permeability, and inhibition of RAB25:FIP complex formation. Treatment of cancer cell lines in which RAB25 is pro-oncogenic with an optimized stapled peptide, RFP14, inhibits migration, and proliferation in a RAB25-dependent manner. In contrast, RFP14 treatment augments these phenotypes in breast cancer cells in which RAB25 is tumor suppressive. Transcriptional profiling identified significantly altered transcripts in response to RAB25 expression, and treatment with RFP14 opposes this expression profile. These data validate the first cell-active chemical probes targeting RAB-family proteins and support the role of RAB25 in regulating context-specific oncogenic phenotypes.The Ras-family small GTPase RAB25 can exert both pro- and anti-oncogenic functions. Here, the authors develop all-hydrocarbon stabilized peptides targeting RAB25 and influencing the context-specificity phenotypes in cancer cell lines." @default.
• W2755015722 created "2017-09-25" @default.
• W2755015722 creator A5008717003 @default.
• W2755015722 creator A5009076140 @default.
• W2755015722 creator A5023317877 @default.
• W2755015722 creator A5025424500 @default.
• W2755015722 creator A5034429970 @default.
• W2755015722 creator A5056501501 @default.
• W2755015722 creator A5074942308 @default.
• W2755015722 creator A5082353065 @default.
• W2755015722 creator A5084233435 @default.
• W2755015722 date "2017-09-22" @default.
• W2755015722 modified "2023-10-16" @default.
• W2755015722 title "Stapled peptide inhibitors of RAB25 target context-specific phenotypes in cancer" @default.
• W2755015722 cites W1887567076 @default.
• W2755015722 cites W198097152 @default.
• W2755015722 cites W1982137523 @default.
• W2755015722 cites W1987805067 @default.
• W2755015722 cites W1992273782 @default.
• W2755015722 cites W1993251792 @default.
• W2755015722 cites W2008845432 @default.
• W2755015722 cites W2009127356 @default.
• W2755015722 cites W2020631983 @default.
• W2755015722 cites W2022387762 @default.
• W2755015722 cites W2029595514 @default.
• W2755015722 cites W2030953184 @default.
• W2755015722 cites W2033390879 @default.
• W2755015722 cites W2040576705 @default.
• W2755015722 cites W2041134111 @default.
• W2755015722 cites W2042061022 @default.
• W2755015722 cites W2060158924 @default.
• W2755015722 cites W2079945282 @default.
• W2755015722 cites W2085948054 @default.
• W2755015722 cites W2087834991 @default.
• W2755015722 cites W2106745747 @default.
• W2755015722 cites W2109613178 @default.
• W2755015722 cites W2112559300 @default.
• W2755015722 cites W2112564899 @default.
• W2755015722 cites W2112751496 @default.
• W2755015722 cites W2116493281 @default.
• W2755015722 cites W2116504572 @default.
• W2755015722 cites W2117940207 @default.
• W2755015722 cites W2119758846 @default.
• W2755015722 cites W2122520505 @default.
• W2755015722 cites W2123061071 @default.
• W2755015722 cites W2130410032 @default.
• W2755015722 cites W2134773861 @default.
• W2755015722 cites W2140114244 @default.
• W2755015722 cites W2144963939 @default.
• W2755015722 cites W2165956359 @default.
• W2755015722 cites W2326124486 @default.
• W2755015722 cites W2418889459 @default.
• W2755015722 cites W2462949473 @default.
• W2755015722 doi "https://doi.org/10.1038/s41467-017-00888-8" @default.
• W2755015722 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5610242" @default.
• W2755015722 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28939823" @default.
• W2755015722 hasPublicationYear "2017" @default.
• W2755015722 type Work @default.
• W2755015722 sameAs 2755015722 @default.
• W2755015722 citedByCount "41" @default.
• W2755015722 countsByYear W27550157222017 @default.
• W2755015722 countsByYear W27550157222018 @default.
• W2755015722 countsByYear W27550157222019 @default.
• W2755015722 countsByYear W27550157222020 @default.
• W2755015722 countsByYear W27550157222021 @default.
• W2755015722 countsByYear W27550157222022 @default.
• W2755015722 countsByYear W27550157222023 @default.
• W2755015722 crossrefType "journal-article" @default.
• W2755015722 hasAuthorship W2755015722A5008717003 @default.
• W2755015722 hasAuthorship W2755015722A5009076140 @default.
• W2755015722 hasAuthorship W2755015722A5023317877 @default.
• W2755015722 hasAuthorship W2755015722A5025424500 @default.
• W2755015722 hasAuthorship W2755015722A5034429970 @default.
• W2755015722 hasAuthorship W2755015722A5056501501 @default.
• W2755015722 hasAuthorship W2755015722A5074942308 @default.
• W2755015722 hasAuthorship W2755015722A5082353065 @default.
• W2755015722 hasAuthorship W2755015722A5084233435 @default.
• W2755015722 hasBestOaLocation W27550157221 @default.
• W2755015722 hasConcept C104317684 @default.
• W2755015722 hasConcept C121608353 @default.
• W2755015722 hasConcept C127716648 @default.
• W2755015722 hasConcept C151730666 @default.
• W2755015722 hasConcept C156728348 @default.
• W2755015722 hasConcept C207332259 @default.
• W2755015722 hasConcept C2779281246 @default.
• W2755015722 hasConcept C2779343474 @default.
• W2755015722 hasConcept C2780298669 @default.
• W2755015722 hasConcept C502942594 @default.
• W2755015722 hasConcept C51785407 @default.
• W2755015722 hasConcept C54355233 @default.
• W2755015722 hasConcept C55493867 @default.
• W2755015722 hasConcept C555283112 @default.
• W2755015722 hasConcept C62478195 @default.
• W2755015722 hasConcept C86803240 @default.
• W2755015722 hasConcept C95444343 @default.
• W2755015722 hasConcept C96232424 @default.
• W2755015722 hasConceptScore W2755015722C104317684 @default.
• W2755015722 hasConceptScore W2755015722C121608353 @default.
• W2755015722 hasConceptScore W2755015722C127716648 @default.
• W2755015722 hasConceptScore W2755015722C151730666 @default.

• next