FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2755057522> ?p ?o ?g. }

• W2755057522 startingPage "347" @default.
• W2755057522 abstract "Ageing is characterized by an impaired functional and structural integrity of mammalian kidneys. A diminished handling of organic compounds, drugs, and water, as observed in the kidneys of older humans and experimental animals, indicates that ageing may affect the expression and/or activity of the renal transporters that mediate excretion and/or reabsorption of organic anions and cations, glucose, and water. We compared the expression of relevant transporters in the kidneys of 3-month- old and 24-month-old male Wistar rats, including Na/K-ATPase, organic anion transporters Oat1 (Slc22a6), Oat2 (Slc22a7), Oat3 (Slc22a8), and Oat5 (Slc22a19), organic cation transporters Oct1 (Slc22a1) and Oct2 (Slc22a2), glucose transporters Sglt1 (Slc5a1) and Sglt2 (Slc5a2), and water channels AQP1 and AQP2. These transporters/channels reside in specific cell membrane domains along the nephron. Protein expression was studied by immunofluorescence cytochemistry (IC) in tissue cryosections and Western blotting (WB) in isolated membranes, whereas expression of mRNA in the tissue was tested by RT-PCR. The protein and mRNA expression of Oat1, Oat3, Oct1, Oct2, and AQP1 was significantly weaker in senescent animals. However, the expression of Na/K-ATPase, Oat2, Oat5, Sglt1, Sglt2, and AQP2 at both protein and/or mRNA levels was not affected by age. Our findings imply that the cellular uptake and excretion of endogenous and/or exogenous compounds in the kidneys can be compromised due to the ageing-related downregulation of certain renal transporters. This can lead to an impaired ability to maintain the homeostasis of specific compounds and an increased susceptibility to drug interaction and toxicity in kidneys and other organs." @default.
• W2755057522 created "2017-09-25" @default.
• W2755057522 creator A5001537665 @default.
• W2755057522 creator A5010280258 @default.
• W2755057522 creator A5011304002 @default.
• W2755057522 creator A5018015933 @default.
• W2755057522 creator A5024138013 @default.
• W2755057522 creator A5029002751 @default.
• W2755057522 creator A5039524620 @default.
• W2755057522 creator A5052777358 @default.
• W2755057522 creator A5055218777 @default.
• W2755057522 creator A5064395949 @default.
• W2755057522 creator A5064438527 @default.
• W2755057522 creator A5066119233 @default.
• W2755057522 creator A5072602807 @default.
• W2755057522 creator A5081544780 @default.
• W2755057522 creator A5086263543 @default.
• W2755057522 date "2013-01-01" @default.
• W2755057522 modified "2023-09-27" @default.
• W2755057522 title "Age-related expression of organic compound and water transporters in rat kidneys" @default.
• W2755057522 hasPublicationYear "2013" @default.
• W2755057522 type Work @default.
• W2755057522 sameAs 2755057522 @default.
• W2755057522 citedByCount "0" @default.
• W2755057522 crossrefType "journal-article" @default.
• W2755057522 hasAuthorship W2755057522A5001537665 @default.
• W2755057522 hasAuthorship W2755057522A5010280258 @default.
• W2755057522 hasAuthorship W2755057522A5011304002 @default.
• W2755057522 hasAuthorship W2755057522A5018015933 @default.
• W2755057522 hasAuthorship W2755057522A5024138013 @default.
• W2755057522 hasAuthorship W2755057522A5029002751 @default.
• W2755057522 hasAuthorship W2755057522A5039524620 @default.
• W2755057522 hasAuthorship W2755057522A5052777358 @default.
• W2755057522 hasAuthorship W2755057522A5055218777 @default.
• W2755057522 hasAuthorship W2755057522A5064395949 @default.
• W2755057522 hasAuthorship W2755057522A5064438527 @default.
• W2755057522 hasAuthorship W2755057522A5066119233 @default.
• W2755057522 hasAuthorship W2755057522A5072602807 @default.
• W2755057522 hasAuthorship W2755057522A5081544780 @default.
• W2755057522 hasAuthorship W2755057522A5086263543 @default.
• W2755057522 hasConcept C104317684 @default.
• W2755057522 hasConcept C123584848 @default.
• W2755057522 hasConcept C126322002 @default.
• W2755057522 hasConcept C127561419 @default.
• W2755057522 hasConcept C134018914 @default.
• W2755057522 hasConcept C149011108 @default.
• W2755057522 hasConcept C161457703 @default.
• W2755057522 hasConcept C185592680 @default.
• W2755057522 hasConcept C189613389 @default.
• W2755057522 hasConcept C2780091579 @default.
• W2755057522 hasConcept C2781231759 @default.
• W2755057522 hasConcept C500499127 @default.
• W2755057522 hasConcept C55493867 @default.
• W2755057522 hasConcept C56906281 @default.
• W2755057522 hasConcept C63645605 @default.
• W2755057522 hasConcept C71924100 @default.
• W2755057522 hasConcept C86803240 @default.
• W2755057522 hasConceptScore W2755057522C104317684 @default.
• W2755057522 hasConceptScore W2755057522C123584848 @default.
• W2755057522 hasConceptScore W2755057522C126322002 @default.
• W2755057522 hasConceptScore W2755057522C127561419 @default.
• W2755057522 hasConceptScore W2755057522C134018914 @default.
• W2755057522 hasConceptScore W2755057522C149011108 @default.
• W2755057522 hasConceptScore W2755057522C161457703 @default.
• W2755057522 hasConceptScore W2755057522C185592680 @default.
• W2755057522 hasConceptScore W2755057522C189613389 @default.
• W2755057522 hasConceptScore W2755057522C2780091579 @default.
• W2755057522 hasConceptScore W2755057522C2781231759 @default.
• W2755057522 hasConceptScore W2755057522C500499127 @default.
• W2755057522 hasConceptScore W2755057522C55493867 @default.
• W2755057522 hasConceptScore W2755057522C56906281 @default.
• W2755057522 hasConceptScore W2755057522C63645605 @default.
• W2755057522 hasConceptScore W2755057522C71924100 @default.
• W2755057522 hasConceptScore W2755057522C86803240 @default.
• W2755057522 hasLocation W27550575221 @default.
• W2755057522 hasOpenAccess W2755057522 @default.
• W2755057522 hasPrimaryLocation W27550575221 @default.
• W2755057522 hasRelatedWork W1979107541 @default.
• W2755057522 hasRelatedWork W1982634744 @default.
• W2755057522 hasRelatedWork W2044153904 @default.
• W2755057522 hasRelatedWork W2048147728 @default.
• W2755057522 hasRelatedWork W2062593378 @default.
• W2755057522 hasRelatedWork W2085563246 @default.
• W2755057522 hasRelatedWork W2113760896 @default.
• W2755057522 hasRelatedWork W2127383456 @default.
• W2755057522 hasRelatedWork W2160034626 @default.
• W2755057522 hasRelatedWork W2164141537 @default.
• W2755057522 hasRelatedWork W2331321029 @default.
• W2755057522 hasRelatedWork W2408337020 @default.
• W2755057522 hasRelatedWork W2739432205 @default.
• W2755057522 hasRelatedWork W2740243638 @default.
• W2755057522 hasRelatedWork W2748265177 @default.
• W2755057522 hasRelatedWork W2752112272 @default.
• W2755057522 hasRelatedWork W2950087211 @default.
• W2755057522 hasRelatedWork W2987547233 @default.
• W2755057522 hasRelatedWork W3006347753 @default.
• W2755057522 hasRelatedWork W3124420925 @default.
• W2755057522 isParatext "false" @default.
• W2755057522 isRetracted "false" @default.

• next