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- W2755072710 abstract "Background Systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) are systemic autoimmune diseases that have overlaping irreversible organ damages. Since SLICC/ACR Damage Index (SDI) misses key features of APS, the Damage Index in patients with Thrombotic Antiphospholipid Syndrome (DIAPS) was proposed. Objectives To assess the differences in indexes available for measuring organ damage in a cohort of patients with SLE and secondary APS. Methods Clinical records of patients with SLE and secondary APS were reviewed. Data on medical history and clinical manifestations were collected. The two damage indexes, SDI and DIAPS, were applied. Comparison between the two indexes was done for each organ system affected. Results Sixty five clinical charts were reviewed, 5 had been excluded for incomplete information. SDI and DIAPS was recorded in 60 patients. Patient9s mean age was 45.05±14.61 years, with mean disease duration of 9.47±6.96 years. Mean SDI in our cohort was 4,15±2.58 and mean DIAPS – 4.08±3.41. SDI correlated significant to DIAPS (R=0.826, p Conclusions SDI may underestimate APS related damage in patients with SLE and secondary regarding neurological and pulmonary organ involvement. Given the implications for high morbidity and mortality, DIAPS may be the appropriate damage score to be used. References P. Alba et al. Organ Damage and Quality of Life in Antiphospholipid Syndrome. Current Rheumatology Reports. February 2016, 18:7. Barbhaiya et al. Utility of the Systemic Lupus International Collaborating Clinics (SLICC)/American College of Rheumatology (ACR) Damage Index for Antiphospholipid Antibody (aPL) Positive Patients. [abstract]. Arthritis Rheum 2011;63 Suppl 10:7. Disclosure of Interest None declared" @default.
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- W2755072710 date "2017-06-01" @default.
- W2755072710 modified "2023-10-18" @default.
- W2755072710 title "THU0266 Damage indexes in patients with systemic lupus erythematosus and secondary antiphospholipid syndrome: diaps vs slicc/acr damage index" @default.
- W2755072710 doi "https://doi.org/10.1136/annrheumdis-2017-eular.4384" @default.
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