Matches in SemOpenAlex for { <https://semopenalex.org/work/W2755142048> ?p ?o ?g. }
- W2755142048 endingPage "2802" @default.
- W2755142048 startingPage "2794" @default.
- W2755142048 abstract "Peptides offer enormous promise as vaccines to prevent and protect against many infectious and noninfectious diseases. However, to date, limited vaccine efficacy has been reported and none have been licensed for human use. Innovative ways to enhance their immunogenicity are being tested, but rational sequence modification as a means to improve immune responsiveness has been neglected. Our objective was to establish a two-step generic protocol to modify defined amino acids of a helical peptide epitope to create a superior immunogen. Peptide variants of p145, a conserved helical peptide epitope from the M protein of Streptococcus pyogenes, were designed by exchanging one amino acid at a time, without altering their α-helical structure, which is required for correct antigenicity. The immunogenicities of new peptides were assessed in outbred mice. Vaccine efficacy was assessed in a skin challenge and invasive disease model. Out of 86 variants of p145, seven amino acid substitutions were selected and made the basis of the design for 18 new peptides. Of these, 13 were more immunogenic than p145; 7 induced Abs with significantly higher affinity for p145 than Abs induced by p145 itself; and 1 peptide induced more than 10,000-fold greater protection following challenge than the parent peptide. This peptide also only required a single immunization (compared with three immunizations with the parent peptide) to induce complete protection against invasive streptococcal disease. This study defines a strategy to rationally improve the immunogenicity of peptides and will have broad applicability to the development of vaccines for infectious and noninfectious diseases." @default.
- W2755142048 created "2017-09-25" @default.
- W2755142048 creator A5001462525 @default.
- W2755142048 creator A5023753165 @default.
- W2755142048 creator A5025426952 @default.
- W2755142048 creator A5027795204 @default.
- W2755142048 creator A5029060934 @default.
- W2755142048 creator A5034193789 @default.
- W2755142048 creator A5035536310 @default.
- W2755142048 creator A5041881846 @default.
- W2755142048 creator A5052305148 @default.
- W2755142048 creator A5057072334 @default.
- W2755142048 creator A5086405597 @default.
- W2755142048 creator A5086608958 @default.
- W2755142048 date "2017-10-15" @default.
- W2755142048 modified "2023-10-13" @default.
- W2755142048 title "Enhancing Vaccine Efficacy by Engineering a Complex Synthetic Peptide To Become a Super Immunogen" @default.
- W2755142048 cites W1031578623 @default.
- W2755142048 cites W1576677426 @default.
- W2755142048 cites W1607368954 @default.
- W2755142048 cites W1976499671 @default.
- W2755142048 cites W2009113958 @default.
- W2755142048 cites W2020019445 @default.
- W2755142048 cites W2024645073 @default.
- W2755142048 cites W2024916519 @default.
- W2755142048 cites W2028693468 @default.
- W2755142048 cites W2034286805 @default.
- W2755142048 cites W2035266068 @default.
- W2755142048 cites W2035687084 @default.
- W2755142048 cites W2057477511 @default.
- W2755142048 cites W2059013803 @default.
- W2755142048 cites W2064388657 @default.
- W2755142048 cites W2066721154 @default.
- W2755142048 cites W2067174909 @default.
- W2755142048 cites W2069168024 @default.
- W2755142048 cites W2092848181 @default.
- W2755142048 cites W2108147481 @default.
- W2755142048 cites W2124667997 @default.
- W2755142048 cites W2167398285 @default.
- W2755142048 cites W2192052049 @default.
- W2755142048 cites W2207495777 @default.
- W2755142048 cites W2323889349 @default.
- W2755142048 cites W2404280981 @default.
- W2755142048 cites W2465010352 @default.
- W2755142048 cites W2513710488 @default.
- W2755142048 cites W2565216971 @default.
- W2755142048 doi "https://doi.org/10.4049/jimmunol.1700836" @default.
- W2755142048 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28904125" @default.
- W2755142048 hasPublicationYear "2017" @default.
- W2755142048 type Work @default.
- W2755142048 sameAs 2755142048 @default.
- W2755142048 citedByCount "13" @default.
- W2755142048 countsByYear W27551420482020 @default.
- W2755142048 countsByYear W27551420482021 @default.
- W2755142048 countsByYear W27551420482022 @default.
- W2755142048 countsByYear W27551420482023 @default.
- W2755142048 crossrefType "journal-article" @default.
- W2755142048 hasAuthorship W2755142048A5001462525 @default.
- W2755142048 hasAuthorship W2755142048A5023753165 @default.
- W2755142048 hasAuthorship W2755142048A5025426952 @default.
- W2755142048 hasAuthorship W2755142048A5027795204 @default.
- W2755142048 hasAuthorship W2755142048A5029060934 @default.
- W2755142048 hasAuthorship W2755142048A5034193789 @default.
- W2755142048 hasAuthorship W2755142048A5035536310 @default.
- W2755142048 hasAuthorship W2755142048A5041881846 @default.
- W2755142048 hasAuthorship W2755142048A5052305148 @default.
- W2755142048 hasAuthorship W2755142048A5057072334 @default.
- W2755142048 hasAuthorship W2755142048A5086405597 @default.
- W2755142048 hasAuthorship W2755142048A5086608958 @default.
- W2755142048 hasBestOaLocation W27551420481 @default.
- W2755142048 hasConcept C104317684 @default.
- W2755142048 hasConcept C159047783 @default.
- W2755142048 hasConcept C159654299 @default.
- W2755142048 hasConcept C167625842 @default.
- W2755142048 hasConcept C185592680 @default.
- W2755142048 hasConcept C195616568 @default.
- W2755142048 hasConcept C203014093 @default.
- W2755142048 hasConcept C2776789287 @default.
- W2755142048 hasConcept C2779026604 @default.
- W2755142048 hasConcept C2779281246 @default.
- W2755142048 hasConcept C2779909307 @default.
- W2755142048 hasConcept C2780868878 @default.
- W2755142048 hasConcept C515207424 @default.
- W2755142048 hasConcept C542903549 @default.
- W2755142048 hasConcept C55493867 @default.
- W2755142048 hasConcept C86803240 @default.
- W2755142048 hasConcept C8891405 @default.
- W2755142048 hasConcept C89423630 @default.
- W2755142048 hasConceptScore W2755142048C104317684 @default.
- W2755142048 hasConceptScore W2755142048C159047783 @default.
- W2755142048 hasConceptScore W2755142048C159654299 @default.
- W2755142048 hasConceptScore W2755142048C167625842 @default.
- W2755142048 hasConceptScore W2755142048C185592680 @default.
- W2755142048 hasConceptScore W2755142048C195616568 @default.
- W2755142048 hasConceptScore W2755142048C203014093 @default.
- W2755142048 hasConceptScore W2755142048C2776789287 @default.
- W2755142048 hasConceptScore W2755142048C2779026604 @default.
- W2755142048 hasConceptScore W2755142048C2779281246 @default.