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• W2755166569 abstract "The Salford Lung Study: a pioneering comparative effectiveness approach to COPD and asthma in clinical trials Timothy E Albertson,1–3 Susan Murin,1,2 Mark E Sutter,2,3 James A Chenoweth2,3 1Department of Internal Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, School of Medicine, University of California, Davis, Sacramento, 2Department of Medicine, Veterans Administration Northern California Healthcare System, Mather, 3Department of Emergency Medicine, School of Medicine, University of California, Davis, Sacramento, CA, USA Abstract: The Salford Lung Study (SLS) of patients with asthma and chronic obstructive pulmonary disease (COPD) is a practical, community-based, randomized, open-label pragmatic study on the efficacy and safety of the once-daily dry powder inhaler that combines the inhaled corticosteroid fluticasone furoate (FF) with the long-acting beta2 agonist vilanterol (VI). The asthma component of the SLS is not yet reported but the COPD component, done over a 12-month period, found a statistically significant 8.4% reduction in COPD exacerbations when compared to usual care. No differences in adverse events, including serious adverse events and pneumonia, were noted. The importance of real-world findings, such as those found in the SLS COPD trial with inhaled FF/VI, is discussed in comparison to classical randomized controlled trials (RCTs) with inhaled FF/VI in COPD patients. The real-world, community-based pragmatic RCT like the SLS provides additional generalizable data with direct clinical applicability and potential usefulness in the development of practice guidelines. The results from the SLS, along with those of large and small RCTs, are supportive of the use of once-daily FF/VI in COPD maintenance therapy. Keywords: Salford Lung Study, pragmatic randomized controlled trials, asthma, COPD, ­fluticasone furoate, FF, vilanterol, VI, COPD exacerbations" @default.
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• W2755166569 date "2017-09-01" @default.
• W2755166569 modified "2023-09-27" @default.
• W2755166569 title "The Salford Lung Study: a pioneering comparative effectiveness approach to COPD and asthma in clinical trials" @default.
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• W2755166569 doi "https://doi.org/10.2147/por.s144157" @default.
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