Matches in SemOpenAlex for { <https://semopenalex.org/work/W2755313511> ?p ?o ?g. }
- W2755313511 endingPage "425" @default.
- W2755313511 startingPage "401" @default.
- W2755313511 abstract "The clinical benefit of memantine for Alzheimer's disease (AD) remains inconclusive.We performed an updated systematic review and meta-analysis of the efficacy/safety of memantine in AD.We included randomized trials of memantine for AD patients. Cognitive function scores (CF), behavioral disturbances scores (BD), and all-cause discontinuation were used as primary measures. Effect size based on a random-effects model was evaluated in the meta-analyses.Thirty studies (n = 7,567; memantine versus placebo: N = 11, n = 3,298; memantine + cholinesterase inhibitors (M+ChEIs) versus ChEIs: N = 17, n = 4,175) were identified. Memantine showed a significant improvement in CF [standardized mean difference (SMD) = -0.24, 95% confidence intervals (95% CIs) = -0.34, -0.15, p < 0.00001, I2 = 35% ] and BD (SMD = -0.16, 95% CIs = -0.29, -0.04, p = 0.01, I2 = 52%) compared with placebo. In the sensitivity analysis including only patients with moderate-severe AD, memantine was superior to the placebo in reducing BD without considerable heterogeneity (SMD = -0.20, 95% CIs = -0.34, -0.07, p = 0.003, I2 = 36%). Compared with ChEIs, M+ChEIs showed a greater reduction in BD (SMD = -0.20, 95% CIs = -0.36, -0.03, p = 0.02, I2 = 77%) and a trend of CF improvement (SMD = -0.11, 95% CIs = -0.22, 0.01, p = 0.06, I2 = 56%). However, in the sensitivity analysis of double-blind, placebo-controlled studies only, M+ChEIs showed a significant reduction in BD compared with ChEIs without considerable heterogeneity (SMD = -0.11, 95% CIs = -0.21, -0.01, p = 0.04, I2 = 40%). When performing the sensitivity analysis of donepezil studies only, M+ChEIs was superior to ChEIs in improving CF without considerable heterogeneity (SMD = -0.18, 95% CIs = -0.31, -0.05, p = 0.006, I2 = 49%). No differences were detected in all-cause discontinuation between the groups.The meta-analyses suggest the credible efficacy and safety of memantine in treating AD when used alone or in combination with ChEIs." @default.
- W2755313511 created "2017-09-25" @default.
- W2755313511 creator A5015137967 @default.
- W2755313511 creator A5018647067 @default.
- W2755313511 creator A5035356286 @default.
- W2755313511 creator A5040100205 @default.
- W2755313511 creator A5067216225 @default.
- W2755313511 creator A5079608463 @default.
- W2755313511 date "2017-09-18" @default.
- W2755313511 modified "2023-10-16" @default.
- W2755313511 title "Memantine for Alzheimer’s Disease: An Updated Systematic Review and Meta-analysis" @default.
- W2755313511 cites W1158443606 @default.
- W2755313511 cites W1507257305 @default.
- W2755313511 cites W1524631360 @default.
- W2755313511 cites W1605020189 @default.
- W2755313511 cites W1847168837 @default.
- W2755313511 cites W1920347567 @default.
- W2755313511 cites W1953027527 @default.
- W2755313511 cites W1971123040 @default.
- W2755313511 cites W1974474435 @default.
- W2755313511 cites W1977427195 @default.
- W2755313511 cites W1991952617 @default.
- W2755313511 cites W1994753147 @default.
- W2755313511 cites W1996776294 @default.
- W2755313511 cites W1999541840 @default.
- W2755313511 cites W2000174679 @default.
- W2755313511 cites W2009141508 @default.
- W2755313511 cites W2022117805 @default.
- W2755313511 cites W2045923955 @default.
- W2755313511 cites W2058112065 @default.
- W2755313511 cites W2058667257 @default.
- W2755313511 cites W2059292019 @default.
- W2755313511 cites W2090211805 @default.
- W2755313511 cites W2091673195 @default.
- W2755313511 cites W2092356280 @default.
- W2755313511 cites W2098008719 @default.
- W2755313511 cites W2102343148 @default.
- W2755313511 cites W2111963393 @default.
- W2755313511 cites W2112519660 @default.
- W2755313511 cites W2117396078 @default.
- W2755313511 cites W2118441096 @default.
- W2755313511 cites W2128047032 @default.
- W2755313511 cites W2132806643 @default.
- W2755313511 cites W2149626554 @default.
- W2755313511 cites W2151585937 @default.
- W2755313511 cites W2153506531 @default.
- W2755313511 cites W2154596951 @default.
- W2755313511 cites W2155997108 @default.
- W2755313511 cites W2156098321 @default.
- W2755313511 cites W2161811803 @default.
- W2755313511 cites W2162321627 @default.
- W2755313511 cites W2163186438 @default.
- W2755313511 cites W2163243818 @default.
- W2755313511 cites W2172010645 @default.
- W2755313511 cites W2179824638 @default.
- W2755313511 cites W2582474237 @default.
- W2755313511 cites W2991792334 @default.
- W2755313511 cites W4211213171 @default.
- W2755313511 doi "https://doi.org/10.3233/jad-170424" @default.
- W2755313511 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28922160" @default.
- W2755313511 hasPublicationYear "2017" @default.
- W2755313511 type Work @default.
- W2755313511 sameAs 2755313511 @default.
- W2755313511 citedByCount "147" @default.
- W2755313511 countsByYear W27553135112018 @default.
- W2755313511 countsByYear W27553135112019 @default.
- W2755313511 countsByYear W27553135112020 @default.
- W2755313511 countsByYear W27553135112021 @default.
- W2755313511 countsByYear W27553135112022 @default.
- W2755313511 countsByYear W27553135112023 @default.
- W2755313511 crossrefType "journal-article" @default.
- W2755313511 hasAuthorship W2755313511A5015137967 @default.
- W2755313511 hasAuthorship W2755313511A5018647067 @default.
- W2755313511 hasAuthorship W2755313511A5035356286 @default.
- W2755313511 hasAuthorship W2755313511A5040100205 @default.
- W2755313511 hasAuthorship W2755313511A5067216225 @default.
- W2755313511 hasAuthorship W2755313511A5079608463 @default.
- W2755313511 hasConcept C126322002 @default.
- W2755313511 hasConcept C142724271 @default.
- W2755313511 hasConcept C168563851 @default.
- W2755313511 hasConcept C204787440 @default.
- W2755313511 hasConcept C27081682 @default.
- W2755313511 hasConcept C2778715236 @default.
- W2755313511 hasConcept C2779056891 @default.
- W2755313511 hasConcept C2779134260 @default.
- W2755313511 hasConcept C2779483572 @default.
- W2755313511 hasConcept C2779484449 @default.
- W2755313511 hasConcept C2780904820 @default.
- W2755313511 hasConcept C28804328 @default.
- W2755313511 hasConcept C44249647 @default.
- W2755313511 hasConcept C71924100 @default.
- W2755313511 hasConcept C95190672 @default.
- W2755313511 hasConceptScore W2755313511C126322002 @default.
- W2755313511 hasConceptScore W2755313511C142724271 @default.
- W2755313511 hasConceptScore W2755313511C168563851 @default.
- W2755313511 hasConceptScore W2755313511C204787440 @default.
- W2755313511 hasConceptScore W2755313511C27081682 @default.
- W2755313511 hasConceptScore W2755313511C2778715236 @default.