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• W2755337536 abstract "The mammalian genome is coiled, compacted and compartmentalized into complex non-random three-dimensional chromatin loops in the nucleus 1–3 . At the core of chromatin loop formation is CCCTC-binding factor (CTCF), also described as a “weaver of the genome” 45 . Anchored by CTCF, chromatin loops are proposed to form through a loop extrusion process 6 , organising themselves into gene neighbourhoods 2 that harbour insulated enhancer-promoter domains, restricting enhancer activities to genes within loops, and insulating genes from promiscuous interactions outside of loops 2,7–9 . Studies targeting CTCF binding site deletions at gene neighbourhood boundaries result in localised gene expression dysregulation 8,10–12 , and global CTCF depletion recently showed CTCF to be crucial for higher hierarchical chromatin organisation of topologically associating domains (TADs) 13 . However, the role for CTCF in maintaining sub-TAD CTCF gene neighbourhoods and how gene transcription is affected by CTCF loss remains unclear. In particular, how CTCF gene neighbourhoods govern genome-wide enhancer-promoter interactions require clarification. Here, we took an in vivo approach to assess the global dissolution of CTCF anchored structures in mouse cardiomyocyte-specific Ctcf -knockout ( Ctcf -KO), and uncovered large-scale ectopic de novo Enhancer-Promoter (E-P) interactions. In vivo cardiomyocyte-specific C tcf -KO leads to a heart failure phenotype 14 , but our analysis integrates genome-wide transcription dysregulation with aberrant E-P interactions in context of CTCF-loop structures, identifying how genes engage their E-P interactions, requiring CTCF looping for their maintenance. Our study points to a mammalian genome that possesses a strong propensity towards spontaneous E-P interactions in vivo , resulting in a diseased transcriptional state, manifest as organ failure. This work solidifies the role of CTCF as the central player for specifying global E-P connections." @default.
• W2755337536 created "2017-09-25" @default.
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• W2755337536 date "2017-09-12" @default.
• W2755337536 modified "2023-10-16" @default.
• W2755337536 title "Gene neighbourhood integrity disrupted by CTCF loss in vivo" @default.
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• W2755337536 doi "https://doi.org/10.1101/187393" @default.
• W2755337536 hasPublicationYear "2017" @default.
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