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• W2755432816 abstract "Significance The biological processes that are involved in the progression of multiple sclerosis (MS) are far from complete. Macrophage migration inhibitory factor (MIF) and its homolog, D-dopachrome tautomerase (D-DT), are immunoregulatory cytokines known to be involved in the worsening of various autoimmune disorders. We demonstrate that genetically controlled high MIF expression (and D-DT) promotes MS progression in males, suggesting that these two factors are sex-specific disease modifiers. In addition, we show that MIF or D-DT deficiency ameliorates the disease severity of the murine model of MS. Our data suggest that targeting CD74, the common receptor for MIF and D-DT, with therapies such as partial MHC class II constructs could be therapeutically beneficial for inhibiting MS clinical progression in selected patients." @default.
• W2755432816 created "2017-09-25" @default.
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• W2755432816 date "2017-09-18" @default.
• W2755432816 modified "2023-10-17" @default.
• W2755432816 title "MIF and D-DT are potential disease severity modifiers in male MS subjects" @default.
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• W2755432816 doi "https://doi.org/10.1073/pnas.1712288114" @default.
• W2755432816 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5635923" @default.
• W2755432816 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28923927" @default.
• W2755432816 hasPublicationYear "2017" @default.
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