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- W2755443795 abstract "e14636 Background: Almost 20-25% of colorectal cancer (CRC) patients present metastases at the time of diagnosis. Multiple signaling pathways have been implied on the stimulation of tumoral angiogenesis, being the VEGF (vascular endothelial growth factor) pathway among the most important ones. Bevacizumab has become standard of care as first line treatment of metastatic CRC (mCRC), after proving increased response rates and improvement in survival outcomes. Hypertension (HTN) is a common complication of the treatment with bevacizumab and due to its close relation with anti-angiogenic mechanism, may represent a clinical biomarker to predict the efficacy of the treatment. The aim of this study was to retrospectively evaluate if HTN grades 2 to 4 were correlated with response to treatment with bevacizumab in first line, as well as with improved progression free survival (PFS) and overall survival (OS), in a series of mCRC patients. Methods: Retrospective evaluation of clinical records of patients with histol..." @default.
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- W2755443795 date "2015-05-20" @default.
- W2755443795 modified "2023-09-27" @default.
- W2755443795 title "Association between bevacizumab-related hypertension and response to treatment in metastatic colorectal cancer patients." @default.
- W2755443795 doi "https://doi.org/10.1200/jco.2015.33.15_suppl.e14636" @default.
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