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- W2755459762 abstract "Makrolidy patři k oblibeným antibiotikům, ale působi cetne lekove interakce. Klarithromycin a roxithromycin jsou inhibitory CYP3A4. To může poskodit pacienty uživajici simvastatin, atorvastatin, verapamil, diltiazem a dalsi substraty CYP3A4. Klarithromycin take inhibuje P-glykoprotein, což zvysuje plazmaticke koncentrace digoxinu, trazodonu, sildenafilu, omeprazolu a glibenklamidu. Klarithromycin a azithromycin prodlužuji interval QT a mohou způsobit arytmii torsade de pointes, což může být potencovano jinými leky s podobným působenim, jako napřiklad amiodaron, sotalol, haloperidol a dalsi. Aby bylo u pacientů riziko lekových interakci sniženo, doporucuje se uzka spoluprace mezi předepisujicimi lekaři, lekarniky a dalsimi odborniky (např. klinický farmakolog nebo farmaceut)." @default.
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- W2755459762 date "2017-07-01" @default.
- W2755459762 modified "2023-10-01" @default.
- W2755459762 title "Macrolides Drug Interactions in 2017" @default.
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- W2755459762 doi "https://doi.org/10.36290/far.2017.010" @default.
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