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- W2755542477 abstract "Recent studies have shown that bipolar disorder (BPD) and schizophrenia (SZ) sharesome common genetic risk factors. This study aimed to examine the associationbetween candidate single nucleotide polymorphisms (SNPs) identified from genomewideassociation studies (GWAS) and risk of BPD and SZ. A total of 715 patients (244BPD and 471 SZ) and 593 controls were genotyped using the Sequenom MassARRAYplatform. We showed a positive association between LMAN2L (rs6746896) and risk ofboth BPD and SZ in a pooled population (P-value=0.001 and 0.009, respectively).Following stratification by ethnicity, variants of the ANK3 gene (rs1938516 andrs10994336) were found to be associated with BPD in Malays (P-value=0.001 and0.006, respectively). Furthermore, an association exists between another variant ofLMAN2L (rs2271893) and SZ in the Malay and Indian ethnic groups (P-value=0.003and 0.002, respectively). Gene-gene interaction analysis revealed a significantinteraction between the ANK3 and LMAN2L genes (empirical P=0.0107). Significantdifferences were shown between patients and controls for two haplotype frequencies ofLMAN2L: GA (P=0.015 and P=0.010, for BPD and SZ, respectively) and GG (P=0.013for BPD). Our study showed a significant association between LMAN2L and risk ofboth BPD and SZ. Although major progress has been achieved in terms of research anddevelopment, there stills exists gap in the knowledge of molecular mechanismsunderlying bipolar disorder (BPD) and action pathway of atypical antipsychotics.MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate geneexpression, including genes involved in neuronal function and plasticity. This studyaimed to examine the changes in miRNA expression in the blood of 14 bipolar maniapatients following 12 weeks of treatment with asenapine and risperidone using miRNAmicroarray. A total of 24 miRNAs were differentially expressed after treatment inasenapine group, 22 of which were significantly up-regulated and the other two wereivsignificantly down-regulated. However, all three differentially expressed miRNAs in therisperidone group were down-regulated. MiRNA target gene prediction and geneontology analysis revealed significant enrichment for pathways associated with immunesystem response and regulation of programmed cell death and transcription. Our resultsshow that miRNAs were involved in the pathway mechanism of both antipsychotics." @default.
- W2755542477 created "2017-09-25" @default.
- W2755542477 creator A5084852487 @default.
- W2755542477 date "2016-01-01" @default.
- W2755542477 modified "2023-09-26" @default.
- W2755542477 title "Bipolar disorder: Microrna profiling and genetics comparison with schizophrenia in a Malaysian population / Lim Chor Hong" @default.
- W2755542477 hasPublicationYear "2016" @default.
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