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- W2755585971 abstract "PD is a progressive neurodegenerative disorder commonly treated by levodopa. The findings from genetic studies on adverse effects (ADRs) and levodopa efficacy are mostly inconclusive. Here, we aim to identify predictive genetic biomarkers for levodopa response (LR) and determine common molecular link with disease susceptibility. A systematic review for LR was conducted for ADR, and drug efficacy, independently. All included articles were assessed for methodological quality on 14 parameters. GWAS of PD were also reviewed. Protein-protein interaction (PPI) analysis using STRING and functional enrichment using WebGestalt was performed to explore the common link between LR and PD.From 37 candidate studies on levodopa toxicity, 18 genes were found associated, of which, CAn STR 13, 14 (DRD2) was most significantly associated with dyskinesia, followed by rs1801133 (MTHFR) with hyper-homocysteinemia, and rs474559 (HOMER1) with hallucination. Similarly, 8 studies on efficacy resulted in 4 genes in which rs28363170, rs3836790 (SLC6A3) and rs4680 (COMT), were significant. To establish the molecular connection between LR with PD, we identified 35 genes significantly associated with PD. With 19 proteins associated with LR and 35 with PD, two independent PPI networks were constructed. Among the 67 nodes (263 edges) in LR, and 62 nodes (190 edges) in PD pathophysiology, UBC, SNCA, FYN, SRC, CAMK2A, and SLC6A3 were identified as common potential candidates.Our study revealed the genetically significant polymorphism concerning the ADRs and levodopa efficacy. The six common genes may be used as predictive markers for therapy optimization and as putative drug target candidates." @default.
- W2755585971 created "2017-09-25" @default.
- W2755585971 creator A5051683315 @default.
- W2755585971 creator A5054248469 @default.
- W2755585971 creator A5063054225 @default.
- W2755585971 creator A5070033249 @default.
- W2755585971 creator A5077055515 @default.
- W2755585971 creator A5084710670 @default.
- W2755585971 creator A5091274298 @default.
- W2755585971 date "2017-09-19" @default.
- W2755585971 modified "2023-10-07" @default.
- W2755585971 title "A systematic review and integrative approach to decode the common molecular link between levodopa response and Parkinson’s disease" @default.
- W2755585971 cites W107978977 @default.
- W2755585971 cites W1498784784 @default.
- W2755585971 cites W1531475515 @default.
- W2755585971 cites W1533056363 @default.
- W2755585971 cites W1596541392 @default.
- W2755585971 cites W1617328014 @default.
- W2755585971 cites W1837404641 @default.
- W2755585971 cites W1964544555 @default.
- W2755585971 cites W1966257984 @default.
- W2755585971 cites W1973301117 @default.
- W2755585971 cites W1973392168 @default.
- W2755585971 cites W1976500430 @default.
- W2755585971 cites W1977982289 @default.
- W2755585971 cites W1979808176 @default.
- W2755585971 cites W1981578529 @default.
- W2755585971 cites W1990518688 @default.
- W2755585971 cites W1999225710 @default.
- W2755585971 cites W1999287190 @default.
- W2755585971 cites W2006329123 @default.
- W2755585971 cites W2006655736 @default.
- W2755585971 cites W2008827081 @default.
- W2755585971 cites W2009028781 @default.
- W2755585971 cites W2009299369 @default.
- W2755585971 cites W2009468127 @default.
- W2755585971 cites W2011464027 @default.
- W2755585971 cites W2011961184 @default.
- W2755585971 cites W2015784684 @default.
- W2755585971 cites W2016819506 @default.
- W2755585971 cites W2018907079 @default.
- W2755585971 cites W2019545285 @default.
- W2755585971 cites W2020583040 @default.
- W2755585971 cites W2021729131 @default.
- W2755585971 cites W2023120986 @default.
- W2755585971 cites W2024131851 @default.
- W2755585971 cites W2024888186 @default.
- W2755585971 cites W2029055973 @default.
- W2755585971 cites W2030459377 @default.
- W2755585971 cites W2034878342 @default.
- W2755585971 cites W2038868125 @default.
- W2755585971 cites W2039740044 @default.
- W2755585971 cites W2039761732 @default.
- W2755585971 cites W2047565527 @default.
- W2755585971 cites W2049451357 @default.
- W2755585971 cites W2049595315 @default.
- W2755585971 cites W2052501164 @default.
- W2755585971 cites W2059219994 @default.
- W2755585971 cites W2064874540 @default.
- W2755585971 cites W2065234871 @default.
- W2755585971 cites W2071024610 @default.
- W2755585971 cites W2075075225 @default.
- W2755585971 cites W2076048008 @default.
- W2755585971 cites W2081643224 @default.
- W2755585971 cites W2081809584 @default.
- W2755585971 cites W2083074337 @default.
- W2755585971 cites W2084179521 @default.
- W2755585971 cites W2085270307 @default.
- W2755585971 cites W2093331618 @default.
- W2755585971 cites W2096173332 @default.
- W2755585971 cites W2108092648 @default.
- W2755585971 cites W2110730012 @default.
- W2755585971 cites W2115110011 @default.
- W2755585971 cites W2116255206 @default.
- W2755585971 cites W2116626531 @default.
- W2755585971 cites W2117598072 @default.
- W2755585971 cites W2118719937 @default.
- W2755585971 cites W2120517210 @default.
- W2755585971 cites W2124001429 @default.
- W2755585971 cites W2124512737 @default.
- W2755585971 cites W2124675313 @default.
- W2755585971 cites W2127069089 @default.
- W2755585971 cites W2128329002 @default.
- W2755585971 cites W2130487306 @default.
- W2755585971 cites W2141459724 @default.
- W2755585971 cites W2142055952 @default.
- W2755585971 cites W2142752948 @default.
- W2755585971 cites W2143717335 @default.
- W2755585971 cites W2144037754 @default.
- W2755585971 cites W2145954079 @default.
- W2755585971 cites W2146481987 @default.
- W2755585971 cites W2148641246 @default.
- W2755585971 cites W2151513507 @default.
- W2755585971 cites W2153032620 @default.
- W2755585971 cites W2165347734 @default.
- W2755585971 cites W2165465283 @default.
- W2755585971 cites W2167856298 @default.
- W2755585971 cites W2299286270 @default.
- W2755585971 cites W2519229002 @default.
- W2755585971 cites W34103945 @default.