FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2755698172> ?p ?o ?g. }

• W2755698172 abstract "Abstract Several pieces of evidence indicate that elastase-2 (ELA2; chymotrypsin-like ELA2) is an alternative pathway to the generation of angiotensin II (ANG II). Elastase-2 knockout mice (ELA2KO) exhibit alterations in the arterial blood pressure and heart rate. However, there is no data on the behavioral consequences of ELA2 deletion. In this study we addressed this question, submitting ELA2KO and wild-type (WT) mice to several models sensitive to anxiety‐ and depression-like, memory, and repetitive behaviors. Our data indicates a higher incidence of barbering behavior in ELA2KO compared to WT, as well as an anxiogenic phenotype, evaluated in the elevated plus maze (EPM). While a decrease in locomotor activity was observed in ELA2KO in EPM, this feature was not the main source of variation in the other parameters analyzed. The marble burying test (MBT) indicated increase in repetitive behavior, observed by a higher number of buried marbles. The actimeter test indicated a decrease in total activity and confirmed the increase in repetitive behavior. The spatial memory was tested by repeated exposure to the actimeter in a 24h interval. Both ELA2KO and WT exhibited decreased activity compared to the first exposure, without any distinction between the genotypes. However, when submitted to the cued fear conditioning, ELA2KO displayed lower levels of freezing behavior in the extinction session when compared to WT, but no difference was observed during the conditioning phase. Increased levels of BDNF were found in the prefrontal cortex but not in the hippocampus of ELA2KO mice compared to WT. Finally, in silico analysis indicates that ELA2 is putatively able to cleave BDNF, and incubation of the purified enzyme with BDNF led to the degradation of the later. Our data suggested an anxiogenic‐ and antidepressant-like phenotype of ELA2KO, possibly associated with increased levels of BDNF in the prefrontal cortex." @default.
• W2755698172 created "2017-09-25" @default.
• W2755698172 creator A5012838715 @default.
• W2755698172 creator A5019744869 @default.
• W2755698172 creator A5023321407 @default.
• W2755698172 creator A5034630796 @default.
• W2755698172 creator A5050563382 @default.
• W2755698172 creator A5052718703 @default.
• W2755698172 creator A5054614831 @default.
• W2755698172 creator A5058457121 @default.
• W2755698172 creator A5059992288 @default.
• W2755698172 creator A5073593635 @default.
• W2755698172 creator A5085905385 @default.
• W2755698172 date "2017-09-12" @default.
• W2755698172 modified "2023-10-18" @default.
• W2755698172 title "Elastase-2 knockout mice display anxiogenic‐ and antidepressant-like phenotype: putative role for BDNF metabolism in prefrontal cortex" @default.
• W2755698172 cites W1501629014 @default.
• W2755698172 cites W1952608928 @default.
• W2755698172 cites W1971258833 @default.
• W2755698172 cites W1972600765 @default.
• W2755698172 cites W1973133147 @default.
• W2755698172 cites W1985298672 @default.
• W2755698172 cites W1992528265 @default.
• W2755698172 cites W1996054063 @default.
• W2755698172 cites W1997438880 @default.
• W2755698172 cites W2000793737 @default.
• W2755698172 cites W2002637584 @default.
• W2755698172 cites W2006399152 @default.
• W2755698172 cites W2009568445 @default.
• W2755698172 cites W2012266823 @default.
• W2755698172 cites W2013597264 @default.
• W2755698172 cites W2024758882 @default.
• W2755698172 cites W2027090772 @default.
• W2755698172 cites W2031598294 @default.
• W2755698172 cites W2033315542 @default.
• W2755698172 cites W2034154112 @default.
• W2755698172 cites W2036499082 @default.
• W2755698172 cites W2043015557 @default.
• W2755698172 cites W2046859561 @default.
• W2755698172 cites W2051423370 @default.
• W2755698172 cites W2053714798 @default.
• W2755698172 cites W2057415261 @default.
• W2755698172 cites W2061369903 @default.
• W2755698172 cites W2064963461 @default.
• W2755698172 cites W2070161412 @default.
• W2755698172 cites W2071580102 @default.
• W2755698172 cites W2081827707 @default.
• W2755698172 cites W2089158799 @default.
• W2755698172 cites W2090083198 @default.
• W2755698172 cites W2092756750 @default.
• W2755698172 cites W2118752824 @default.
• W2755698172 cites W2122062108 @default.
• W2755698172 cites W2131167630 @default.
• W2755698172 cites W2151861216 @default.
• W2755698172 cites W2156689577 @default.
• W2755698172 cites W2168950597 @default.
• W2755698172 cites W2172294286 @default.
• W2755698172 cites W2307941755 @default.
• W2755698172 cites W2474861912 @default.
• W2755698172 cites W2527911119 @default.
• W2755698172 cites W2556295310 @default.
• W2755698172 cites W2590746114 @default.
• W2755698172 cites W2607000919 @default.
• W2755698172 doi "https://doi.org/10.1101/187831" @default.
• W2755698172 hasPublicationYear "2017" @default.
• W2755698172 type Work @default.
• W2755698172 sameAs 2755698172 @default.
• W2755698172 citedByCount "0" @default.
• W2755698172 crossrefType "posted-content" @default.
• W2755698172 hasAuthorship W2755698172A5012838715 @default.
• W2755698172 hasAuthorship W2755698172A5019744869 @default.
• W2755698172 hasAuthorship W2755698172A5023321407 @default.
• W2755698172 hasAuthorship W2755698172A5034630796 @default.
• W2755698172 hasAuthorship W2755698172A5050563382 @default.
• W2755698172 hasAuthorship W2755698172A5052718703 @default.
• W2755698172 hasAuthorship W2755698172A5054614831 @default.
• W2755698172 hasAuthorship W2755698172A5058457121 @default.
• W2755698172 hasAuthorship W2755698172A5059992288 @default.
• W2755698172 hasAuthorship W2755698172A5073593635 @default.
• W2755698172 hasAuthorship W2755698172A5085905385 @default.
• W2755698172 hasBestOaLocation W27556981721 @default.
• W2755698172 hasConcept C118552586 @default.
• W2755698172 hasConcept C126322002 @default.
• W2755698172 hasConcept C134018914 @default.
• W2755698172 hasConcept C15744967 @default.
• W2755698172 hasConcept C16837860 @default.
• W2755698172 hasConcept C169760540 @default.
• W2755698172 hasConcept C169900460 @default.
• W2755698172 hasConcept C170493617 @default.
• W2755698172 hasConcept C173586616 @default.
• W2755698172 hasConcept C182704531 @default.
• W2755698172 hasConcept C185592680 @default.
• W2755698172 hasConcept C205044023 @default.
• W2755698172 hasConcept C2777765862 @default.
• W2755698172 hasConcept C2779144063 @default.
• W2755698172 hasConcept C2781069985 @default.
• W2755698172 hasConcept C2781161787 @default.
• W2755698172 hasConcept C2781195155 @default.
• W2755698172 hasConcept C558461103 @default.
• W2755698172 hasConcept C71924100 @default.

• next