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• W2755740599 abstract "Objective: We investigated whether antioxidants may enhance bioavailability of lipids and carbohydrates and therefore increase the risk of obesity development.Methods: We tested how supplementation with antioxidants (0.01% butylated hydroxytoluene [BHT], α-tocopherol, and green tea catechins) of a diet containing butter and wheat bread affects bioavailability of fats and carbohydrates. The absorption of the in vitro digested diet was estimated in the intestinal epithelia model of the Caco-2 cells cultured in Transwell chambers.Results: In the case of the antioxidant-supplemented diets, we observed increased bioavailability of glucose, cholesterol, and lipids, as well as elevated secretion of the main chylomicron protein apoB-48 to the basal compartment. Importantly, we did not detect any rise in the concentrations of lipid peroxidation products (malondialdehyde, MDA) in the control samples prepared without antioxidants.Conclusions: Addition of antioxidants (in particular BHT) to the diet increases bioavailability of lipids and carbohydrates, which consequently may increase the risk of obesity development. The dose of antioxidants is a factor of fundamental importance, particularly for catechins: low doses increase absorption of lipids, whereas high doses exert the opposite effect." @default.
• W2755740599 created "2017-09-25" @default.
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• W2755740599 date "2017-09-12" @default.
• W2755740599 modified "2023-10-11" @default.
• W2755740599 title "Food Stabilizing Antioxidants Increase Nutrient Bioavailability in the<i>in Vitro</i>Model" @default.
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• W2755740599 doi "https://doi.org/10.1080/07315724.2017.1333930" @default.
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