Matches in SemOpenAlex for { <https://semopenalex.org/work/W2755870045> ?p ?o ?g. }
- W2755870045 endingPage "117" @default.
- W2755870045 startingPage "105" @default.
- W2755870045 abstract "Invasive lobular breast cancer (ILC) is an understudied malignancy with distinct clinical, pathological, and molecular features that distinguish it from the more common invasive ductal carcinoma (IDC). Mounting evidence suggests that estrogen receptor-alpha positive (ER+) ILC has a poor response to Tamoxifen (TAM), but the mechanistic drivers of this are undefined. In the current work, we comprehensively characterize the SUM44/LCCTam ILC cell model system through integrated analysis of gene expression, copy number, and mutation, with the goal of identifying actionable alterations relevant to clinical ILC that can be co-targeted along with ER to improve treatment outcomes. We show that TAM has several distinct effects on the transcriptome of LCCTam cells, that this resistant cell model has acquired copy number alterations and mutations that impinge on MAPK and metabotropic glutamate receptor (GRM/mGluR) signaling networks, and that pharmacological inhibition of either improves or restores the growth-inhibitory actions of endocrine therapy." @default.
- W2755870045 created "2017-09-25" @default.
- W2755870045 creator A5006025566 @default.
- W2755870045 creator A5018284345 @default.
- W2755870045 creator A5031065480 @default.
- W2755870045 creator A5032949456 @default.
- W2755870045 creator A5035266638 @default.
- W2755870045 creator A5043648679 @default.
- W2755870045 creator A5056434383 @default.
- W2755870045 creator A5056590283 @default.
- W2755870045 creator A5059145284 @default.
- W2755870045 creator A5066098323 @default.
- W2755870045 creator A5073368743 @default.
- W2755870045 creator A5081852175 @default.
- W2755870045 creator A5090624365 @default.
- W2755870045 date "2018-08-01" @default.
- W2755870045 modified "2023-10-17" @default.
- W2755870045 title "Integrated molecular analysis of Tamoxifen-resistant invasive lobular breast cancer cells identifies MAPK and GRM/mGluR signaling as therapeutic vulnerabilities" @default.
- W2755870045 cites W1517844922 @default.
- W2755870045 cites W1782413320 @default.
- W2755870045 cites W1889928106 @default.
- W2755870045 cites W1908864745 @default.
- W2755870045 cites W1934888046 @default.
- W2755870045 cites W1965050427 @default.
- W2755870045 cites W1967099832 @default.
- W2755870045 cites W1973058068 @default.
- W2755870045 cites W1977859620 @default.
- W2755870045 cites W1979032468 @default.
- W2755870045 cites W1980357874 @default.
- W2755870045 cites W1984068087 @default.
- W2755870045 cites W1985794577 @default.
- W2755870045 cites W1988647505 @default.
- W2755870045 cites W1992053143 @default.
- W2755870045 cites W1996060670 @default.
- W2755870045 cites W1998203489 @default.
- W2755870045 cites W1998466702 @default.
- W2755870045 cites W1999143039 @default.
- W2755870045 cites W2000266878 @default.
- W2755870045 cites W2002262418 @default.
- W2755870045 cites W2005585150 @default.
- W2755870045 cites W2005895632 @default.
- W2755870045 cites W2016059827 @default.
- W2755870045 cites W2017735822 @default.
- W2755870045 cites W2018120348 @default.
- W2755870045 cites W2021456586 @default.
- W2755870045 cites W2023057398 @default.
- W2755870045 cites W2023637925 @default.
- W2755870045 cites W2024412473 @default.
- W2755870045 cites W2027604384 @default.
- W2755870045 cites W2031646117 @default.
- W2755870045 cites W2031864635 @default.
- W2755870045 cites W2032080189 @default.
- W2755870045 cites W2042386089 @default.
- W2755870045 cites W2046389285 @default.
- W2755870045 cites W2046410395 @default.
- W2755870045 cites W2046640029 @default.
- W2755870045 cites W2048015102 @default.
- W2755870045 cites W2059944523 @default.
- W2755870045 cites W2061043894 @default.
- W2755870045 cites W2063685408 @default.
- W2755870045 cites W2070170290 @default.
- W2755870045 cites W2071906362 @default.
- W2755870045 cites W2074619468 @default.
- W2755870045 cites W2079791855 @default.
- W2755870045 cites W2086072858 @default.
- W2755870045 cites W2089595068 @default.
- W2755870045 cites W2092902159 @default.
- W2755870045 cites W2094114923 @default.
- W2755870045 cites W2096791516 @default.
- W2755870045 cites W2101844536 @default.
- W2755870045 cites W2102004296 @default.
- W2755870045 cites W2102217018 @default.
- W2755870045 cites W2103441770 @default.
- W2755870045 cites W2107617686 @default.
- W2755870045 cites W2108234281 @default.
- W2755870045 cites W2111689182 @default.
- W2755870045 cites W2114364250 @default.
- W2755870045 cites W2114843025 @default.
- W2755870045 cites W2115950635 @default.
- W2755870045 cites W2116831158 @default.
- W2755870045 cites W2118850482 @default.
- W2755870045 cites W2119180969 @default.
- W2755870045 cites W2122955072 @default.
- W2755870045 cites W2125618744 @default.
- W2755870045 cites W2133174470 @default.
- W2755870045 cites W2134672574 @default.
- W2755870045 cites W2136321713 @default.
- W2755870045 cites W2141630969 @default.
- W2755870045 cites W2143836666 @default.
- W2755870045 cites W2146906901 @default.
- W2755870045 cites W2149441684 @default.
- W2755870045 cites W2152856165 @default.
- W2755870045 cites W2155208115 @default.
- W2755870045 cites W2158629784 @default.
- W2755870045 cites W2159674539 @default.
- W2755870045 cites W2161650611 @default.
- W2755870045 cites W2162829389 @default.
- W2755870045 cites W2163957613 @default.