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• W2755959812 abstract "Atherosclerosis is the leading cause of mortality in developed countries accounting for 50% of all deaths. Atherosclerosis develops when macrophages in the artery wall accumulate large amounts of cholesterol via uptake of oxidized low density lipoproteins (LDL), causing a negative effect on cholesterol metabolism. Thus, the development of atherosclerosis can be inhibited by increasing cholesterol efflux, which can be achieved by activating ATP binding cassette (ABC) transporters in macrophages. In particular, ABCA1 mediates reverse cholesterol transport to the liver via high density lipoproteins (HDL) and therefore is an attractive molecular target for raising HDL levels and protecting against atherosclerosis. ABCA1 gene expression is known to be regulated by various transcription factors, such as liver X receptor (LXR). LXRs are transcription factors that are activated via binding of ligands, which are oxysterols. Activated LXRs bind to promoter regions at specific sequences known as LXR response elements (LXRE) and regulate genes for cholesterol metabolism and transport, as well as for lipogenesis. Synthetic LXR ligands might be useful for treatment of atherosclerosis if they did not induce lipogenesis, which can lead to an accumulation of cholesterol via activation of steroid response element binding protein (SREBP)-1c in the liver. To develop selective treatments for atherosclerosis, we need to understand mechanisms of selective gene regulation. LXRs occur as two isotypes, LXRα (NR1H3) and LXRβ (NR1H2). Both isotypes regulate genes encoding proteins involved in cholesterol metabolism and transport, as well as in lipogenesis. However, knock-out studies have shown that LXRβ activation results in more effective gene activation in the periphery, such as in macrophages, which can promote cholesterol efflux. The mechanism of this LXR isotype-selectivity is poorly understood. In this document, we will show how protein-protein interactions affect LXRα and LXRβ function and explore the mechanism of nuclear export of LXRα and LXRβ." @default.
• W2755959812 created "2017-09-25" @default.
• W2755959812 creator A5048506077 @default.
• W2755959812 date "2022-06-17" @default.
• W2755959812 modified "2023-09-29" @default.
• W2755959812 title "14-3-3 sigma interacts with liver X receptor beta" @default.
• W2755959812 cites W1565506774 @default.
• W2755959812 cites W1570388980 @default.
• W2755959812 cites W1572091120 @default.
• W2755959812 cites W1756681973 @default.
• W2755959812 cites W1869751044 @default.
• W2755959812 cites W1963733386 @default.
• W2755959812 cites W1965779516 @default.
• W2755959812 cites W1968682237 @default.
• W2755959812 cites W1969839676 @default.
• W2755959812 cites W1973243569 @default.
• W2755959812 cites W1973331161 @default.
• W2755959812 cites W1975070287 @default.
• W2755959812 cites W1978406914 @default.
• W2755959812 cites W1979983012 @default.
• W2755959812 cites W1980823210 @default.
• W2755959812 cites W1982715024 @default.
• W2755959812 cites W1986256219 @default.
• W2755959812 cites W1987300505 @default.
• W2755959812 cites W1996168740 @default.
• W2755959812 cites W1998476442 @default.
• W2755959812 cites W1999459848 @default.
• W2755959812 cites W2002757138 @default.
• W2755959812 cites W2003798182 @default.
• W2755959812 cites W2003840075 @default.
• W2755959812 cites W2006902704 @default.
• W2755959812 cites W2010060957 @default.
• W2755959812 cites W2010762097 @default.
• W2755959812 cites W2013452582 @default.
• W2755959812 cites W2014967781 @default.
• W2755959812 cites W2015970807 @default.
• W2755959812 cites W2016146562 @default.
• W2755959812 cites W2016153572 @default.
• W2755959812 cites W2016211755 @default.
• W2755959812 cites W2024679015 @default.
• W2755959812 cites W2024851295 @default.
• W2755959812 cites W2024923170 @default.
• W2755959812 cites W2025991358 @default.
• W2755959812 cites W2026587556 @default.
• W2755959812 cites W2028561801 @default.
• W2755959812 cites W2030442022 @default.
• W2755959812 cites W2031267915 @default.
• W2755959812 cites W2031906658 @default.
• W2755959812 cites W2034640494 @default.
• W2755959812 cites W2034790783 @default.
• W2755959812 cites W2037657431 @default.
• W2755959812 cites W2039664177 @default.
• W2755959812 cites W2040053707 @default.
• W2755959812 cites W2041781038 @default.
• W2755959812 cites W2042901562 @default.
• W2755959812 cites W2044272700 @default.
• W2755959812 cites W2049557712 @default.
• W2755959812 cites W2056128228 @default.
• W2755959812 cites W2056152639 @default.
• W2755959812 cites W2056385716 @default.
• W2755959812 cites W2057940509 @default.
• W2755959812 cites W2058205407 @default.
• W2755959812 cites W2061425356 @default.
• W2755959812 cites W2062441923 @default.
• W2755959812 cites W2064112442 @default.
• W2755959812 cites W2066677392 @default.
• W2755959812 cites W2068124794 @default.
• W2755959812 cites W2071075259 @default.
• W2755959812 cites W2071263028 @default.
• W2755959812 cites W2071792338 @default.
• W2755959812 cites W2077895194 @default.
• W2755959812 cites W2078391564 @default.
• W2755959812 cites W2079266078 @default.
• W2755959812 cites W2081594562 @default.
• W2755959812 cites W2081732968 @default.
• W2755959812 cites W2081846665 @default.
• W2755959812 cites W2082974905 @default.
• W2755959812 cites W2083240338 @default.
• W2755959812 cites W2085909854 @default.
• W2755959812 cites W2085999239 @default.
• W2755959812 cites W2088167128 @default.
• W2755959812 cites W2092904031 @default.
• W2755959812 cites W2093296161 @default.
• W2755959812 cites W2094960965 @default.
• W2755959812 cites W2096576561 @default.
• W2755959812 cites W2101226009 @default.
• W2755959812 cites W2104606103 @default.
• W2755959812 cites W2105259330 @default.
• W2755959812 cites W2106169706 @default.
• W2755959812 cites W2107825795 @default.
• W2755959812 cites W2109041281 @default.
• W2755959812 cites W2110964364 @default.
• W2755959812 cites W2112555162 @default.
• W2755959812 cites W2112632255 @default.
• W2755959812 cites W2113456624 @default.
• W2755959812 cites W2113624181 @default.
• W2755959812 cites W2117639596 @default.
• W2755959812 cites W2119133998 @default.
• W2755959812 cites W2121416807 @default.
• W2755959812 cites W2122203755 @default.

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