Matches in SemOpenAlex for { <https://semopenalex.org/work/W2755978093> ?p ?o ?g. }
- W2755978093 abstract "Abstract Various types of cell can change the cytoskeleton and shed microvesicles (MVs) with biomimic properties as parent cells in response to stimuli. To take use of the drug package capability of MVs and the potent antigen presentation property of dendritic cells (DCs), DC‐derived antigenic MVs are constructed by priming DCs with tumor‐derived MVs and then encapsulating a chemotherapeutic drug during MVs shedding. This kind of MVs exhibit significant inhibition on melanoma tumor growth and metastasis. The MV‐encapsulated chemotherapeutics can induce direct cytotoxicity and immunogenic cell death in tumor cells. Moreover, a robust antitumor immunity is induced in both, the tumor‐draining lymph node and the tumor microenvironment as the infiltration and activation of T lymphocytes increases. This kind of MVs is further explored in a hepatic ascites model with remarkable prolonged overall survival of mice. More importantly, the MVs can extend the survival of 60% mice more than 150 d without ascites even after rechallenging the tumor twice. This study demonstrates that antigenic MVs with chemotherapeutics possess great potential in cancer immunochemotherapy." @default.
- W2755978093 created "2017-09-25" @default.
- W2755978093 creator A5010386480 @default.
- W2755978093 creator A5011331686 @default.
- W2755978093 creator A5020655470 @default.
- W2755978093 creator A5038335020 @default.
- W2755978093 creator A5045203230 @default.
- W2755978093 creator A5077281667 @default.
- W2755978093 creator A5081093007 @default.
- W2755978093 creator A5085822353 @default.
- W2755978093 creator A5086559201 @default.
- W2755978093 date "2017-09-13" @default.
- W2755978093 modified "2023-10-16" @default.
- W2755978093 title "Bone Marrow Dendritic Cells Derived Microvesicles for Combinational Immunochemotherapy against Tumor" @default.
- W2755978093 cites W1485973300 @default.
- W2755978093 cites W1509098294 @default.
- W2755978093 cites W1546466517 @default.
- W2755978093 cites W1557759563 @default.
- W2755978093 cites W1574076960 @default.
- W2755978093 cites W1585393472 @default.
- W2755978093 cites W1661544713 @default.
- W2755978093 cites W1790202563 @default.
- W2755978093 cites W1930288242 @default.
- W2755978093 cites W1950118853 @default.
- W2755978093 cites W1963573377 @default.
- W2755978093 cites W1964186644 @default.
- W2755978093 cites W1965781173 @default.
- W2755978093 cites W1972070926 @default.
- W2755978093 cites W1977945339 @default.
- W2755978093 cites W1980008292 @default.
- W2755978093 cites W1986328483 @default.
- W2755978093 cites W1989884371 @default.
- W2755978093 cites W1992699637 @default.
- W2755978093 cites W1998670692 @default.
- W2755978093 cites W2002148098 @default.
- W2755978093 cites W2008494452 @default.
- W2755978093 cites W2010558399 @default.
- W2755978093 cites W2023797723 @default.
- W2755978093 cites W2025132904 @default.
- W2755978093 cites W2039793277 @default.
- W2755978093 cites W2042634738 @default.
- W2755978093 cites W2043461098 @default.
- W2755978093 cites W2044835625 @default.
- W2755978093 cites W2045127348 @default.
- W2755978093 cites W2047003662 @default.
- W2755978093 cites W2047529823 @default.
- W2755978093 cites W2048883725 @default.
- W2755978093 cites W2053929414 @default.
- W2755978093 cites W2054029124 @default.
- W2755978093 cites W2066843867 @default.
- W2755978093 cites W2074939270 @default.
- W2755978093 cites W2081527131 @default.
- W2755978093 cites W2082511916 @default.
- W2755978093 cites W2084262527 @default.
- W2755978093 cites W2084785039 @default.
- W2755978093 cites W2089905323 @default.
- W2755978093 cites W2092643850 @default.
- W2755978093 cites W2093860844 @default.
- W2755978093 cites W2094854776 @default.
- W2755978093 cites W2100927341 @default.
- W2755978093 cites W2102284924 @default.
- W2755978093 cites W2102449174 @default.
- W2755978093 cites W2113053092 @default.
- W2755978093 cites W2120426523 @default.
- W2755978093 cites W2127404676 @default.
- W2755978093 cites W2142153200 @default.
- W2755978093 cites W2152608358 @default.
- W2755978093 cites W2158545805 @default.
- W2755978093 cites W2160571820 @default.
- W2755978093 cites W2162759745 @default.
- W2755978093 cites W2170552969 @default.
- W2755978093 cites W2171618078 @default.
- W2755978093 cites W2176296660 @default.
- W2755978093 cites W2177327503 @default.
- W2755978093 cites W2198779459 @default.
- W2755978093 cites W2209812019 @default.
- W2755978093 cites W2226509526 @default.
- W2755978093 cites W2279217276 @default.
- W2755978093 cites W2281375963 @default.
- W2755978093 cites W2297358480 @default.
- W2755978093 cites W2324677651 @default.
- W2755978093 cites W2436942341 @default.
- W2755978093 cites W2511954851 @default.
- W2755978093 cites W2519575997 @default.
- W2755978093 cites W262134620 @default.
- W2755978093 doi "https://doi.org/10.1002/adfm.201703191" @default.
- W2755978093 hasPublicationYear "2017" @default.
- W2755978093 type Work @default.
- W2755978093 sameAs 2755978093 @default.
- W2755978093 citedByCount "38" @default.
- W2755978093 countsByYear W27559780932018 @default.
- W2755978093 countsByYear W27559780932019 @default.
- W2755978093 countsByYear W27559780932020 @default.
- W2755978093 countsByYear W27559780932021 @default.
- W2755978093 countsByYear W27559780932022 @default.
- W2755978093 countsByYear W27559780932023 @default.
- W2755978093 crossrefType "journal-article" @default.
- W2755978093 hasAuthorship W2755978093A5010386480 @default.
- W2755978093 hasAuthorship W2755978093A5011331686 @default.
- W2755978093 hasAuthorship W2755978093A5020655470 @default.