FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2756123025> ?p ?o ?g. }

• W2756123025 endingPage "126" @default.
• W2756123025 startingPage "119" @default.
• W2756123025 abstract "Inward migration of cerebellar granule cells (CGCs) after birth is critical for lamination in the cerebellar cortex. N-methyl-d-aspartate (NMDA) subtype of glutamate receptor (NMDAR) tethering CGCs into Bergmann glial fibers mediates the inward movement during the glial-dependent migratory phase. Activation of NMDAR depends on simultaneous binding of the GluN2 subunit by glutamate, and of the GluN1 subunit by d-serine or glycine; d-serine is believed to be an endogenous ligand of NMDAR. We hypothesized that lamination of the cerebellar cortex may be compromised in Srr (the gene for serine racemase (SR)) mutated mice (Srrnull) because of significantly low levels of d-serine per se. Indeed, the external germinal cell layer (EGL) in Srrnull was thicker than in sibling wild-type (WT) mice on postnatal day7 (P7), which accords with decreased CGC migration in Srrnull mice. However, the cerebellar laminar structure in Srrnull mice was normal on P12 and later. Feeding d-serine to pregnant mice abrogated the increased EGL thickness in Srrnull mice on P7. To determine the underlying mechanism of abnormal laminar structure during cerebellar development in Srrnull mice, we examined NMDAR subunits and their ligands. We found increased GluN2B on P10 and increased glycine during P7–12 in the cerebellar homogenates from Srrnull mice compared with the corresponding values from sibling WT mice. In summary, the study revealed how the potential defect in early cerebellar development caused by Srr mutation is circumvented by a compensatory mechanism. This knowledge advances understanding of the adaptation of cerebellar development under the condition of Srr mutation." @default.
• W2756123025 created "2017-09-25" @default.
• W2756123025 creator A5021491883 @default.
• W2756123025 creator A5026072320 @default.
• W2756123025 creator A5053611692 @default.
• W2756123025 creator A5064323494 @default.
• W2756123025 creator A5072769611 @default.
• W2756123025 creator A5087920969 @default.
• W2756123025 creator A5088532176 @default.
• W2756123025 date "2017-12-01" @default.
• W2756123025 modified "2023-09-26" @default.
• W2756123025 title "Potential deficit from decreased cerebellar granule cell migration in serine racemase-deficient mice is reversed by increased expression of GluN2B and elevated levels of NMDAR agonists" @default.
• W2756123025 cites W1509222372 @default.
• W2756123025 cites W1582772752 @default.
• W2756123025 cites W1608352250 @default.
• W2756123025 cites W1896110412 @default.
• W2756123025 cites W1964764373 @default.
• W2756123025 cites W1975641065 @default.
• W2756123025 cites W1997325127 @default.
• W2756123025 cites W2001900235 @default.
• W2756123025 cites W2007234880 @default.
• W2756123025 cites W2021222610 @default.
• W2756123025 cites W2025809696 @default.
• W2756123025 cites W2048181000 @default.
• W2756123025 cites W2051909860 @default.
• W2756123025 cites W2058485466 @default.
• W2756123025 cites W2070178074 @default.
• W2756123025 cites W2071060745 @default.
• W2756123025 cites W2072098760 @default.
• W2756123025 cites W2074683128 @default.
• W2756123025 cites W2077211332 @default.
• W2756123025 cites W2080137645 @default.
• W2756123025 cites W2087690085 @default.
• W2756123025 cites W2098956752 @default.
• W2756123025 cites W2103272211 @default.
• W2756123025 cites W2110787178 @default.
• W2756123025 cites W2123111710 @default.
• W2756123025 cites W2137389296 @default.
• W2756123025 cites W2145566795 @default.
• W2756123025 cites W2156313574 @default.
• W2756123025 cites W2156974196 @default.
• W2756123025 cites W2157023792 @default.
• W2756123025 cites W2159680923 @default.
• W2756123025 cites W2163945368 @default.
• W2756123025 cites W2164167794 @default.
• W2756123025 cites W2345272602 @default.
• W2756123025 doi "https://doi.org/10.1016/j.mcn.2017.09.005" @default.
• W2756123025 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28939329" @default.
• W2756123025 hasPublicationYear "2017" @default.
• W2756123025 type Work @default.
• W2756123025 sameAs 2756123025 @default.
• W2756123025 citedByCount "9" @default.
• W2756123025 countsByYear W27561230252018 @default.
• W2756123025 countsByYear W27561230252020 @default.
• W2756123025 countsByYear W27561230252021 @default.
• W2756123025 countsByYear W27561230252022 @default.
• W2756123025 crossrefType "journal-article" @default.
• W2756123025 hasAuthorship W2756123025A5021491883 @default.
• W2756123025 hasAuthorship W2756123025A5026072320 @default.
• W2756123025 hasAuthorship W2756123025A5053611692 @default.
• W2756123025 hasAuthorship W2756123025A5064323494 @default.
• W2756123025 hasAuthorship W2756123025A5072769611 @default.
• W2756123025 hasAuthorship W2756123025A5087920969 @default.
• W2756123025 hasAuthorship W2756123025A5088532176 @default.
• W2756123025 hasConcept C11960822 @default.
• W2756123025 hasConcept C126322002 @default.
• W2756123025 hasConcept C134018914 @default.
• W2756123025 hasConcept C169760540 @default.
• W2756123025 hasConcept C170493617 @default.
• W2756123025 hasConcept C2776414213 @default.
• W2756123025 hasConcept C2776464000 @default.
• W2756123025 hasConcept C2778888523 @default.
• W2756123025 hasConcept C2779652256 @default.
• W2756123025 hasConcept C2780648746 @default.
• W2756123025 hasConcept C2992333117 @default.
• W2756123025 hasConcept C529278444 @default.
• W2756123025 hasConcept C55493867 @default.
• W2756123025 hasConcept C61174792 @default.
• W2756123025 hasConcept C67018056 @default.
• W2756123025 hasConcept C71924100 @default.
• W2756123025 hasConcept C86803240 @default.
• W2756123025 hasConcept C95444343 @default.
• W2756123025 hasConceptScore W2756123025C11960822 @default.
• W2756123025 hasConceptScore W2756123025C126322002 @default.
• W2756123025 hasConceptScore W2756123025C134018914 @default.
• W2756123025 hasConceptScore W2756123025C169760540 @default.
• W2756123025 hasConceptScore W2756123025C170493617 @default.
• W2756123025 hasConceptScore W2756123025C2776414213 @default.
• W2756123025 hasConceptScore W2756123025C2776464000 @default.
• W2756123025 hasConceptScore W2756123025C2778888523 @default.
• W2756123025 hasConceptScore W2756123025C2779652256 @default.
• W2756123025 hasConceptScore W2756123025C2780648746 @default.
• W2756123025 hasConceptScore W2756123025C2992333117 @default.
• W2756123025 hasConceptScore W2756123025C529278444 @default.
• W2756123025 hasConceptScore W2756123025C55493867 @default.
• W2756123025 hasConceptScore W2756123025C61174792 @default.
• W2756123025 hasConceptScore W2756123025C67018056 @default.
• W2756123025 hasConceptScore W2756123025C71924100 @default.

• next