FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2756163907> ?p ?o ?g. }

• W2756163907 endingPage "916" @default.
• W2756163907 startingPage "908" @default.
• W2756163907 abstract "Malignant pleural effusions (MPEs) are often observed in lung cancer, particularly adenocarcinoma. The aim of this study was to investigate epidermal growth factor receptor (EGFR) mutation status in lung adenocarcinoma-associated MPEs (LA-MPEs) and its correlation with efficacy of EGFR tyrosine kinase inhibitor (TKI) therapy.Samples comprised 40 cell blocks of pathologically-confirmed LA-MPEs collected before the start of EGFR TKI therapy. EGFR mutation status was re-evaluated by peptide nucleic acid clamping and the clinical outcomes of EGFR TKI‒treated patients were analyzed retrospectively.EGFR mutations were detected in 72.5% of LA-MPE cell blocks (29/40). The median progression-free survival for patients with EGFR mutations in LA-MPEs was better than that for patients with wild-type EGFR (7.33 months vs. 2.07 months; hazard ratio, 0.486; 95% confidence interval, 0.206 to 1.144; p=0.032). The objective response rate (ORR) of 26 patients with EGFR mutations in LA-MPEs among the 36 patients with measurable lesions was 80.8%, while the ORR of the 10 patients with wild-type EGFR in LA-MPEs was 10% (p < 0.001). Among the 26 patients with EGFR mutations in LA-MPEs, the ORR of target lesions and LA-MPEs were 88.5% and 61.5%, respectively (p=0.026).EGFR mutation status in cell blocks of LA-MPEs confirmed by pathologic diagnosis is highly predictive of EGFR TKI efficacy. For patients with EGFR mutations in LA-MPEs, the response to EGFR TKIs seems to be worse for pleural effusions than for solid tumors." @default.
• W2756163907 created "2017-09-25" @default.
• W2756163907 creator A5005962138 @default.
• W2756163907 creator A5028262443 @default.
• W2756163907 creator A5037457804 @default.
• W2756163907 creator A5042404237 @default.
• W2756163907 creator A5055483008 @default.
• W2756163907 creator A5076196426 @default.
• W2756163907 creator A5082502616 @default.
• W2756163907 creator A5084687090 @default.
• W2756163907 creator A5091383420 @default.
• W2756163907 date "2018-07-15" @default.
• W2756163907 modified "2023-10-13" @default.
• W2756163907 title "EGFR Mutation Status in Lung Adenocarcinoma-Associated Malignant Pleural Effusion and Efficacy of EGFR Tyrosine Kinase Inhibitors" @default.
• W2756163907 cites W1969716254 @default.
• W2756163907 cites W1969800769 @default.
• W2756163907 cites W1973191130 @default.
• W2756163907 cites W1986788912 @default.
• W2756163907 cites W2003652790 @default.
• W2756163907 cites W2015028559 @default.
• W2756163907 cites W2019607817 @default.
• W2756163907 cites W2023046316 @default.
• W2756163907 cites W2028593825 @default.
• W2756163907 cites W2036189924 @default.
• W2756163907 cites W2037139573 @default.
• W2756163907 cites W2041738335 @default.
• W2756163907 cites W2043696829 @default.
• W2756163907 cites W2051803356 @default.
• W2756163907 cites W2053736534 @default.
• W2756163907 cites W2057377134 @default.
• W2756163907 cites W2075093416 @default.
• W2756163907 cites W2078618371 @default.
• W2756163907 cites W2086118690 @default.
• W2756163907 cites W2101100749 @default.
• W2756163907 cites W2137729785 @default.
• W2756163907 cites W2159803213 @default.
• W2756163907 cites W2163582146 @default.
• W2756163907 cites W2167034708 @default.
• W2756163907 cites W2170829864 @default.
• W2756163907 cites W2403654892 @default.
• W2756163907 cites W2570618306 @default.
• W2756163907 cites W2581533425 @default.
• W2756163907 doi "https://doi.org/10.4143/crt.2017.378" @default.
• W2756163907 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6056963" @default.
• W2756163907 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28934846" @default.
• W2756163907 hasPublicationYear "2018" @default.
• W2756163907 type Work @default.
• W2756163907 sameAs 2756163907 @default.
• W2756163907 citedByCount "29" @default.
• W2756163907 countsByYear W27561639072018 @default.
• W2756163907 countsByYear W27561639072019 @default.
• W2756163907 countsByYear W27561639072020 @default.
• W2756163907 countsByYear W27561639072021 @default.
• W2756163907 countsByYear W27561639072022 @default.
• W2756163907 countsByYear W27561639072023 @default.
• W2756163907 crossrefType "journal-article" @default.
• W2756163907 hasAuthorship W2756163907A5005962138 @default.
• W2756163907 hasAuthorship W2756163907A5028262443 @default.
• W2756163907 hasAuthorship W2756163907A5037457804 @default.
• W2756163907 hasAuthorship W2756163907A5042404237 @default.
• W2756163907 hasAuthorship W2756163907A5055483008 @default.
• W2756163907 hasAuthorship W2756163907A5076196426 @default.
• W2756163907 hasAuthorship W2756163907A5082502616 @default.
• W2756163907 hasAuthorship W2756163907A5084687090 @default.
• W2756163907 hasAuthorship W2756163907A5091383420 @default.
• W2756163907 hasBestOaLocation W27561639071 @default.
• W2756163907 hasConcept C121608353 @default.
• W2756163907 hasConcept C126322002 @default.
• W2756163907 hasConcept C143998085 @default.
• W2756163907 hasConcept C170493617 @default.
• W2756163907 hasConcept C207103383 @default.
• W2756163907 hasConcept C2776232967 @default.
• W2756163907 hasConcept C2776256026 @default.
• W2756163907 hasConcept C2778820342 @default.
• W2756163907 hasConcept C2779438470 @default.
• W2756163907 hasConcept C2779634585 @default.
• W2756163907 hasConcept C2780580887 @default.
• W2756163907 hasConcept C2781182431 @default.
• W2756163907 hasConcept C42362537 @default.
• W2756163907 hasConcept C44249647 @default.
• W2756163907 hasConcept C502942594 @default.
• W2756163907 hasConcept C71924100 @default.
• W2756163907 hasConceptScore W2756163907C121608353 @default.
• W2756163907 hasConceptScore W2756163907C126322002 @default.
• W2756163907 hasConceptScore W2756163907C143998085 @default.
• W2756163907 hasConceptScore W2756163907C170493617 @default.
• W2756163907 hasConceptScore W2756163907C207103383 @default.
• W2756163907 hasConceptScore W2756163907C2776232967 @default.
• W2756163907 hasConceptScore W2756163907C2776256026 @default.
• W2756163907 hasConceptScore W2756163907C2778820342 @default.
• W2756163907 hasConceptScore W2756163907C2779438470 @default.
• W2756163907 hasConceptScore W2756163907C2779634585 @default.
• W2756163907 hasConceptScore W2756163907C2780580887 @default.
• W2756163907 hasConceptScore W2756163907C2781182431 @default.
• W2756163907 hasConceptScore W2756163907C42362537 @default.
• W2756163907 hasConceptScore W2756163907C44249647 @default.
• W2756163907 hasConceptScore W2756163907C502942594 @default.
• W2756163907 hasConceptScore W2756163907C71924100 @default.

• next