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• W2756164615 endingPage "1048" @default.
• W2756164615 startingPage "1040" @default.
• W2756164615 abstract "As an important intermediate feedstock, succinate is termed as one of the 12 bio-based platform chemicals. To improve its fermentative production, various strategies have been developed, but challenges are still ahead for succinate biosynthesis to be cost-competitive. In this article, strategies for succinate production through metabolic engineering of Escherichia coli are critically reviewed, with a focus on engineering by-product formation and CO2 fixation, substrate utilization, reducing power balance, metabolic evolution and transcriptional regulation, which provide insights for the current state of succinate production and perspectives for further research for more efficient and economical production of bio-based succinate." @default.
• W2756164615 created "2017-09-25" @default.
• W2756164615 creator A5014508314 @default.
• W2756164615 creator A5021957184 @default.
• W2756164615 date "2017-12-01" @default.
• W2756164615 modified "2023-10-17" @default.
• W2756164615 title "Current advances of succinate biosynthesis in metabolically engineered Escherichia coli" @default.
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