Matches in SemOpenAlex for { <https://semopenalex.org/work/W2756182007> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2756182007 abstract "Clopidogrel is a thienopryridine antiplatelet agent commonly used in the management of cardiovascular diseases. Clopidogrel is metabolized by hepatic CYP2C19 and CYP2B6, therefore, co-administration of clopidogrel and CYP2C19 inhibitors can alter pharmacokinetics of clopidogrel. Omeprazole is a proton pump inhibitor used for decreasing gastric acid production. Omeprazole is known to be a potent inhibitor of CYP2C19. Thus when the drugs are simultaneously administered, clopidogrel plasma concentration levels can be increased. However, plasma levels of the active metabolite of clopidogrel can be significantly decreased, thereby, its antiplatelet activity is reduced.We aimed to develop a mathematical model describing a drug-drug interaction between clopidogrel and omeprazole in humans.Searching for pharmacokinetic interaction studies between clopidogrel and omeprazole in humans was performed in PubMed. Six studies were selected into our modeling purposes to develop 3 mathematical models (i.e. 4 studies for clopidogrel alone, 1 study for omeprazole alone and 1 study for clopidogrel-omeprazole interaction). Subsequently, concentration-time course data from the selected studies were extracted. Computer codes and simulations were performed using the Advanced Continuous Simulating Language Extreme (ACSLX) program.We successfully developed 3 mathematical models which are able to describe all of the datasets.Our clopidogrel-omeprazole pharmacokinetic interaction model with a description of competitive inhibition at CYP2C19 could successfully describe concentration-time courses from the selected datasets. Our interaction model may be useful in predicting plasma levels of clopidogrel and its active metabolite." @default.
- W2756182007 created "2017-09-25" @default.
- W2756182007 creator A5016964058 @default.
- W2756182007 creator A5068381359 @default.
- W2756182007 creator A5069544422 @default.
- W2756182007 creator A5081301464 @default.
- W2756182007 creator A5084668968 @default.
- W2756182007 date "2017-07-01" @default.
- W2756182007 modified "2023-09-25" @default.
- W2756182007 title "A pharmacokinetic model of drug-drug interaction between clopidogrel and omeprazole at CYP2C19 in humans" @default.
- W2756182007 cites W1970709974 @default.
- W2756182007 cites W1986451071 @default.
- W2756182007 cites W1988708673 @default.
- W2756182007 cites W1989260524 @default.
- W2756182007 cites W2026270873 @default.
- W2756182007 cites W2032247889 @default.
- W2756182007 cites W2036267503 @default.
- W2756182007 cites W2058852350 @default.
- W2756182007 cites W2064805417 @default.
- W2756182007 cites W2071687773 @default.
- W2756182007 cites W2102233898 @default.
- W2756182007 cites W2110602156 @default.
- W2756182007 cites W2113513640 @default.
- W2756182007 cites W2128322996 @default.
- W2756182007 cites W2144766297 @default.
- W2756182007 cites W2145425156 @default.
- W2756182007 cites W2172775913 @default.
- W2756182007 cites W2295327363 @default.
- W2756182007 cites W2296523961 @default.
- W2756182007 cites W2312868916 @default.
- W2756182007 cites W2312876940 @default.
- W2756182007 cites W2570328141 @default.
- W2756182007 doi "https://doi.org/10.1109/embc.2017.8037415" @default.
- W2756182007 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29060457" @default.
- W2756182007 hasPublicationYear "2017" @default.
- W2756182007 type Work @default.
- W2756182007 sameAs 2756182007 @default.
- W2756182007 citedByCount "1" @default.
- W2756182007 countsByYear W27561820072022 @default.
- W2756182007 crossrefType "proceedings-article" @default.
- W2756182007 hasAuthorship W2756182007A5016964058 @default.
- W2756182007 hasAuthorship W2756182007A5068381359 @default.
- W2756182007 hasAuthorship W2756182007A5069544422 @default.
- W2756182007 hasAuthorship W2756182007A5081301464 @default.
- W2756182007 hasAuthorship W2756182007A5084668968 @default.
- W2756182007 hasConcept C112705442 @default.
- W2756182007 hasConcept C126322002 @default.
- W2756182007 hasConcept C140840227 @default.
- W2756182007 hasConcept C149151106 @default.
- W2756182007 hasConcept C185592680 @default.
- W2756182007 hasConcept C2777265216 @default.
- W2756182007 hasConcept C2777477808 @default.
- W2756182007 hasConcept C2777498785 @default.
- W2756182007 hasConcept C2777628954 @default.
- W2756182007 hasConcept C2777849778 @default.
- W2756182007 hasConcept C2780035454 @default.
- W2756182007 hasConcept C2781025758 @default.
- W2756182007 hasConcept C526171541 @default.
- W2756182007 hasConcept C62231903 @default.
- W2756182007 hasConcept C71924100 @default.
- W2756182007 hasConcept C97320921 @default.
- W2756182007 hasConcept C98274493 @default.
- W2756182007 hasConceptScore W2756182007C112705442 @default.
- W2756182007 hasConceptScore W2756182007C126322002 @default.
- W2756182007 hasConceptScore W2756182007C140840227 @default.
- W2756182007 hasConceptScore W2756182007C149151106 @default.
- W2756182007 hasConceptScore W2756182007C185592680 @default.
- W2756182007 hasConceptScore W2756182007C2777265216 @default.
- W2756182007 hasConceptScore W2756182007C2777477808 @default.
- W2756182007 hasConceptScore W2756182007C2777498785 @default.
- W2756182007 hasConceptScore W2756182007C2777628954 @default.
- W2756182007 hasConceptScore W2756182007C2777849778 @default.
- W2756182007 hasConceptScore W2756182007C2780035454 @default.
- W2756182007 hasConceptScore W2756182007C2781025758 @default.
- W2756182007 hasConceptScore W2756182007C526171541 @default.
- W2756182007 hasConceptScore W2756182007C62231903 @default.
- W2756182007 hasConceptScore W2756182007C71924100 @default.
- W2756182007 hasConceptScore W2756182007C97320921 @default.
- W2756182007 hasConceptScore W2756182007C98274493 @default.
- W2756182007 hasLocation W27561820071 @default.
- W2756182007 hasLocation W27561820072 @default.
- W2756182007 hasOpenAccess W2756182007 @default.
- W2756182007 hasPrimaryLocation W27561820071 @default.
- W2756182007 hasRelatedWork W1789574908 @default.
- W2756182007 hasRelatedWork W1859232251 @default.
- W2756182007 hasRelatedWork W1890388819 @default.
- W2756182007 hasRelatedWork W1992257495 @default.
- W2756182007 hasRelatedWork W1998449260 @default.
- W2756182007 hasRelatedWork W2075200277 @default.
- W2756182007 hasRelatedWork W2118534378 @default.
- W2756182007 hasRelatedWork W2166861655 @default.
- W2756182007 hasRelatedWork W2240990962 @default.
- W2756182007 hasRelatedWork W2756182007 @default.
- W2756182007 isParatext "false" @default.
- W2756182007 isRetracted "false" @default.
- W2756182007 magId "2756182007" @default.
- W2756182007 workType "article" @default.