FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2756197753> ?p ?o ?g. }

• W2756197753 abstract "Background Cytopenia in the course of systemic lupus erythematosus (SLE) may be due to multiple factors. One of these factors can be SLE-associated autoimmune myelofibrosis (AIMF). However, the frequency of SLE-associated AIMF is not well known and the role of clinical and laboratory parameters in the development of AIMF is not clear. Objectives Our aim was to identify the frequency of SLE-associated AIMF and compared SLE-associated AIMF group with non-AIMF group in terms of clinical findings and morphological properties of the bone marrow (BM) in cytopenic SLE patients. Methods We retrospectively analyzed 224 SLE patients9 files who met 1997 revised Classification criteria for SLE. BM aspirates and trephine biopsies were re-examinded. Patients were divided into two groups according to whether they had myelofibrosis or not (AIMF and non-AIMF groups). Concurrent SLE organ involvements, and drugs given pre- and post-AIMF were recorded. BM cellularity, the presence of fibrosis (reticulin or collagen) and grade of fibrosis, the presence of dysplasia, and lymphoid infiltration were recorded. Results 45 (20%) of 224 SLE patients were found to experienced BM biopsy due to cytopenia. Four patients were excluded from analyses (2 drug-induced cytopenia, 1 lymphoma, 1 insufficient BM biopsy samples). While AIMF was detected in 29 (70.7%) of the 41 patients, 12 patients did not have AIMF. All patients with AIMF had reticulin fibrosis, 2 patients (6.9%) had also collagen fibrosis. Between the AIMF and non-AIMF groups, no differences were identified in terms of erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), SLEDAI, BM cellularity, or BM dysplastic changes (p=0.989, p=0.387, p=0.788, p=0.672, and p=0.494, respectively). In the AIMF group, 27 patients responded to immunosuppressive therapy and corticosteroids, but 2 patients were unresponsive. The response time was longer for the AIMF group compared to the non-AIMF group (3.3±3.1 months vs 1.7±1.2 months, p=0.091). Correlation analysis revealed that higher the grade of BM fibrosis, longer the response time (r=0.471, p=0.002). Conclusions AIMF may be underestimated in SLE patients. AIMF as an additional factor for cytopenia in SLE patients may lead to delayed response to appropriate therapy, which was dependent on the presence of high grade fibrosis. Acknowledgements None declared Disclosure of Interest None declared" @default.
• W2756197753 created "2017-09-25" @default.
• W2756197753 creator A5009644469 @default.
• W2756197753 creator A5046418483 @default.
• W2756197753 creator A5064303361 @default.
• W2756197753 creator A5078378018 @default.
• W2756197753 date "2017-06-01" @default.
• W2756197753 modified "2023-10-15" @default.
• W2756197753 title "SAT0237 Bone marrow as a target organ of systemic lupus erythematosus: analysis of cases with autoimmune myelofibrosis" @default.
• W2756197753 doi "https://doi.org/10.1136/annrheumdis-2017-eular.4330" @default.
• W2756197753 hasPublicationYear "2017" @default.
• W2756197753 type Work @default.
• W2756197753 sameAs 2756197753 @default.
• W2756197753 citedByCount "0" @default.
• W2756197753 crossrefType "proceedings-article" @default.
• W2756197753 hasAuthorship W2756197753A5009644469 @default.
• W2756197753 hasAuthorship W2756197753A5046418483 @default.
• W2756197753 hasAuthorship W2756197753A5064303361 @default.
• W2756197753 hasAuthorship W2756197753A5078378018 @default.
• W2756197753 hasBestOaLocation W27561977531 @default.
• W2756197753 hasConcept C126322002 @default.
• W2756197753 hasConcept C142724271 @default.
• W2756197753 hasConcept C2775894508 @default.
• W2756197753 hasConcept C2775934546 @default.
• W2756197753 hasConcept C2776232749 @default.
• W2756197753 hasConcept C2779338263 @default.
• W2756197753 hasConcept C2780007613 @default.
• W2756197753 hasConcept C2780076729 @default.
• W2756197753 hasConcept C2780366003 @default.
• W2756197753 hasConcept C2780559512 @default.
• W2756197753 hasConcept C71924100 @default.
• W2756197753 hasConcept C90924648 @default.
• W2756197753 hasConceptScore W2756197753C126322002 @default.
• W2756197753 hasConceptScore W2756197753C142724271 @default.
• W2756197753 hasConceptScore W2756197753C2775894508 @default.
• W2756197753 hasConceptScore W2756197753C2775934546 @default.
• W2756197753 hasConceptScore W2756197753C2776232749 @default.
• W2756197753 hasConceptScore W2756197753C2779338263 @default.
• W2756197753 hasConceptScore W2756197753C2780007613 @default.
• W2756197753 hasConceptScore W2756197753C2780076729 @default.
• W2756197753 hasConceptScore W2756197753C2780366003 @default.
• W2756197753 hasConceptScore W2756197753C2780559512 @default.
• W2756197753 hasConceptScore W2756197753C71924100 @default.
• W2756197753 hasConceptScore W2756197753C90924648 @default.
• W2756197753 hasLocation W27561977531 @default.
• W2756197753 hasOpenAccess W2756197753 @default.
• W2756197753 hasPrimaryLocation W27561977531 @default.
• W2756197753 hasRelatedWork W1970541029 @default.
• W2756197753 hasRelatedWork W1972736283 @default.
• W2756197753 hasRelatedWork W2045076264 @default.
• W2756197753 hasRelatedWork W2183139284 @default.
• W2756197753 hasRelatedWork W2357313337 @default.
• W2756197753 hasRelatedWork W2358222914 @default.
• W2756197753 hasRelatedWork W2367223010 @default.
• W2756197753 hasRelatedWork W2391130096 @default.
• W2756197753 hasRelatedWork W2509948048 @default.
• W2756197753 hasRelatedWork W2789467458 @default.
• W2756197753 hasRelatedWork W2794551530 @default.
• W2756197753 hasRelatedWork W2794696290 @default.
• W2756197753 hasRelatedWork W2804044732 @default.
• W2756197753 hasRelatedWork W2911075580 @default.
• W2756197753 hasRelatedWork W2935917039 @default.
• W2756197753 hasRelatedWork W2985113976 @default.
• W2756197753 hasRelatedWork W2991812878 @default.
• W2756197753 hasRelatedWork W3086357763 @default.
• W2756197753 hasRelatedWork W3092525752 @default.
• W2756197753 hasRelatedWork W3112383244 @default.
• W2756197753 isParatext "false" @default.
• W2756197753 isRetracted "false" @default.
• W2756197753 magId "2756197753" @default.
• W2756197753 workType "article" @default.