Matches in SemOpenAlex for { <https://semopenalex.org/work/W2756212983> ?p ?o ?g. }
- W2756212983 abstract "Abstract Irreversible electroporation (IRE) as a non-thermal tumor ablation technology has been studied for the treatment of pancreatic carcinoma and has shown a significant survival benefit. We discovered that moderate heating (MH) at 43 °C for 1-2 minutes significantly enhanced ex vivo IRE tumor ablation of Pan02 cells by 5.67-fold at 750 V/cm and by 1.67-fold at 1500 V/cm. This amount of heating alone did not cause cell death. An integrated IRE system with controllable laser heating and tumor impedance monitoring was developed to treat mouse ectopic pancreatic cancer. With this novel IRE system, we were able to heat and maintain the temperature of a targeted tumor area at 42 °C during IRE treatment. Pre-heating the tumor greatly reduced the impedance of tumor and its fluctuation. Most importantly, MHIRE has been demonstrated to significantly extend median survival and achieve a high rate of complete tumor regression. Median survival was 43, 46 and 84 days, for control, IRE with 100 μs, 1 Hz, 90 pulses and electric fields 2000–2500 V/cm and MHIRE treatment respectively. 55.6% of tumor-bearing mice treated with MHIRE were tumor-free, whereas complete tumor regression was not observed in the control and IRE treatment groups." @default.
- W2756212983 created "2017-09-25" @default.
- W2756212983 creator A5014207909 @default.
- W2756212983 creator A5014266369 @default.
- W2756212983 creator A5024979833 @default.
- W2756212983 creator A5025388791 @default.
- W2756212983 creator A5043765121 @default.
- W2756212983 creator A5045768131 @default.
- W2756212983 creator A5057362562 @default.
- W2756212983 creator A5062405676 @default.
- W2756212983 creator A5068223679 @default.
- W2756212983 date "2017-09-18" @default.
- W2756212983 modified "2023-09-29" @default.
- W2756212983 title "Controllable Moderate Heating Enhances the Therapeutic Efficacy of Irreversible Electroporation for Pancreatic Cancer" @default.
- W2756212983 cites W1543287659 @default.
- W2756212983 cites W1985367511 @default.
- W2756212983 cites W1986190753 @default.
- W2756212983 cites W2002193311 @default.
- W2756212983 cites W2004155851 @default.
- W2756212983 cites W2010300713 @default.
- W2756212983 cites W2019068717 @default.
- W2756212983 cites W2019264784 @default.
- W2756212983 cites W2020803344 @default.
- W2756212983 cites W2029341128 @default.
- W2756212983 cites W2030550720 @default.
- W2756212983 cites W2035252444 @default.
- W2756212983 cites W2036630385 @default.
- W2756212983 cites W2037961348 @default.
- W2756212983 cites W2043729132 @default.
- W2756212983 cites W2067485994 @default.
- W2756212983 cites W2078695541 @default.
- W2756212983 cites W2080280001 @default.
- W2756212983 cites W2084272274 @default.
- W2756212983 cites W2084319978 @default.
- W2756212983 cites W2098895604 @default.
- W2756212983 cites W2101863964 @default.
- W2756212983 cites W2114367134 @default.
- W2756212983 cites W2118933681 @default.
- W2756212983 cites W2122041824 @default.
- W2756212983 cites W2122352794 @default.
- W2756212983 cites W2123540787 @default.
- W2756212983 cites W2138155367 @default.
- W2756212983 cites W2141861000 @default.
- W2756212983 cites W2144206175 @default.
- W2756212983 cites W2149131370 @default.
- W2756212983 cites W2156124327 @default.
- W2756212983 cites W2161817637 @default.
- W2756212983 cites W2162209366 @default.
- W2756212983 cites W2168597967 @default.
- W2756212983 cites W2209487660 @default.
- W2756212983 cites W2297967082 @default.
- W2756212983 cites W2316268583 @default.
- W2756212983 cites W2342828177 @default.
- W2756212983 cites W2509371025 @default.
- W2756212983 cites W2529080716 @default.
- W2756212983 cites W2571609853 @default.
- W2756212983 cites W2612531804 @default.
- W2756212983 cites W2621536941 @default.
- W2756212983 cites W2915480655 @default.
- W2756212983 cites W99374617 @default.
- W2756212983 doi "https://doi.org/10.1038/s41598-017-12227-4" @default.
- W2756212983 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5603521" @default.
- W2756212983 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28924200" @default.
- W2756212983 hasPublicationYear "2017" @default.
- W2756212983 type Work @default.
- W2756212983 sameAs 2756212983 @default.
- W2756212983 citedByCount "32" @default.
- W2756212983 countsByYear W27562129832018 @default.
- W2756212983 countsByYear W27562129832019 @default.
- W2756212983 countsByYear W27562129832020 @default.
- W2756212983 countsByYear W27562129832021 @default.
- W2756212983 countsByYear W27562129832022 @default.
- W2756212983 countsByYear W27562129832023 @default.
- W2756212983 crossrefType "journal-article" @default.
- W2756212983 hasAuthorship W2756212983A5014207909 @default.
- W2756212983 hasAuthorship W2756212983A5014266369 @default.
- W2756212983 hasAuthorship W2756212983A5024979833 @default.
- W2756212983 hasAuthorship W2756212983A5025388791 @default.
- W2756212983 hasAuthorship W2756212983A5043765121 @default.
- W2756212983 hasAuthorship W2756212983A5045768131 @default.
- W2756212983 hasAuthorship W2756212983A5057362562 @default.
- W2756212983 hasAuthorship W2756212983A5062405676 @default.
- W2756212983 hasAuthorship W2756212983A5068223679 @default.
- W2756212983 hasBestOaLocation W27562129831 @default.
- W2756212983 hasConcept C104317684 @default.
- W2756212983 hasConcept C121608353 @default.
- W2756212983 hasConcept C126322002 @default.
- W2756212983 hasConcept C126894567 @default.
- W2756212983 hasConcept C143998085 @default.
- W2756212983 hasConcept C150903083 @default.
- W2756212983 hasConcept C185592680 @default.
- W2756212983 hasConcept C186852380 @default.
- W2756212983 hasConcept C207001950 @default.
- W2756212983 hasConcept C26291073 @default.
- W2756212983 hasConcept C2778716261 @default.
- W2756212983 hasConcept C2778902805 @default.
- W2756212983 hasConcept C2779949491 @default.
- W2756212983 hasConcept C2780210213 @default.
- W2756212983 hasConcept C502942594 @default.
- W2756212983 hasConcept C55493867 @default.