FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2756213969> ?p ?o ?g. }

• W2756213969 endingPage "84065" @default.
• W2756213969 startingPage "84054" @default.
• W2756213969 abstract "// Haochang Hu 1, * , Xiaoying Chen 1, * , Cheng Wang 2, * , Yuting Jiang 1 , Jingjing Li 3 , Xiuru Ying 1 , Yong Yang 1 , Bin Li 1 , Cong Zhou 1 , Jie Zhong 1 , Dongping Wu 2 , Jieer Ying 3 and Shiwei Duan 1 1 Medical Genetics Center, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, China 2 Department of Medical Oncology, Shaoxing People’s Hospital, Shaoxing Hospital of Zhejiang University, Zhejiang 312000, China 3 Department of Medical Oncology, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, China * Co-first authors Correspondence to: Shiwei Duan, email: duanshiwei@nbu.edu.cn Jieer Ying, email: jieerying@aliyun.com Keywords: tissue factor pathway inhibitor 2, DNA methylation, gastric cancer, colorectal cancer, quantitative methylation-specific polymerase chain reaction Received: November 30, 2016      Accepted: August 28, 2017      Published: September 20, 2017 ABSTRACT Gastrointestinal cancer is a prevalent disease with high morbidity and mortality. Tissue factor pathway inhibitor 2 ( TFPI2 ) gene could protect the extracellular matrix of cancer cells from degradation and tumor invasion. The goal of our study was to estimate the diagnostic value of TFPI2 hypermethylation in gastric cancer (GC) and colorectal cancer (CRC). TFPI2 methylation was measured by quantitative methylation-specific polymerase chain reaction (qMSP) method in 114 GC and 80 CRC tissues and their paired non-tumor tissues. Our results showed that TFPI2 methylation was significantly higher in tumor tissues (GC: 29.940% vs. 12.785%, P < 0.001; CRC: 26.930% vs. 5.420%, P < 0.001). The methylation level of TFPI2 in colorectal tumor tissues was significantly higher than that in colorectal normal tissues (26.930% versus 0.002%, P < 0.00001). In GC, TFPI2 hypermethylation yielded an area under the curve (AUC) of 0.762 (95% CI: 0.696–0.828) with a sensitivity of 68% and a specificity of 83%. In CRC, TFPI2 hypermethylation yielded an AUC of 0.759 (95% CI: 0.685–0.834) with a sensitivity of 61% and a specificity of 84%. Similarly, TCGA data also supported TFPI2 hypermethylation was a promising diagnostic marker for GC and CRC. Moreover, the dual-luciferase reporter assay showed TFPI2 fragment could upregulate gene expression (fold change = 5, P = 0.005). Data mining further indicated that TFPI2 expression in CRC cell lines was significantly increased after 5’-AZA-deoxycytidine treatment (fold change > 1.37). In conclusion, TFPI2 hypermethylation might be a promising diagnostic biomarker for GC and CRC." @default.
• W2756213969 created "2017-09-25" @default.
• W2756213969 creator A5005211285 @default.
• W2756213969 creator A5015696308 @default.
• W2756213969 creator A5017947601 @default.
• W2756213969 creator A5021249077 @default.
• W2756213969 creator A5029695887 @default.
• W2756213969 creator A5042636471 @default.
• W2756213969 creator A5048541371 @default.
• W2756213969 creator A5052095171 @default.
• W2756213969 creator A5075321325 @default.
• W2756213969 creator A5075517974 @default.
• W2756213969 creator A5078881653 @default.
• W2756213969 creator A5082203333 @default.
• W2756213969 creator A5091873057 @default.
• W2756213969 date "2017-09-20" @default.
• W2756213969 modified "2023-09-30" @default.
• W2756213969 title "The role of <i>TFPI2</i> hypermethylation in the detection of gastric and colorectal cancer" @default.
• W2756213969 cites W1623182829 @default.
• W2756213969 cites W1839681254 @default.
• W2756213969 cites W1967466510 @default.
• W2756213969 cites W1967475753 @default.
• W2756213969 cites W1968907488 @default.
• W2756213969 cites W1974324374 @default.
• W2756213969 cites W1981407851 @default.
• W2756213969 cites W1983631645 @default.
• W2756213969 cites W2002180158 @default.
• W2756213969 cites W2005253607 @default.
• W2756213969 cites W2006667358 @default.
• W2756213969 cites W2013185838 @default.
• W2756213969 cites W2021786261 @default.
• W2756213969 cites W2034066925 @default.
• W2756213969 cites W2043880263 @default.
• W2756213969 cites W2049656449 @default.
• W2756213969 cites W2052665087 @default.
• W2756213969 cites W2066245403 @default.
• W2756213969 cites W2075658137 @default.
• W2756213969 cites W2093958280 @default.
• W2756213969 cites W2106836326 @default.
• W2756213969 cites W2111853146 @default.
• W2756213969 cites W2132192577 @default.
• W2756213969 cites W2132545223 @default.
• W2756213969 cites W2140394554 @default.
• W2756213969 cites W2141671690 @default.
• W2756213969 cites W2143097992 @default.
• W2756213969 cites W2147626573 @default.
• W2756213969 cites W2160383539 @default.
• W2756213969 cites W2160392555 @default.
• W2756213969 cites W2164791558 @default.
• W2756213969 cites W2170915948 @default.
• W2756213969 cites W2181758489 @default.
• W2756213969 cites W2181892250 @default.
• W2756213969 cites W2188271323 @default.
• W2756213969 cites W2189538297 @default.
• W2756213969 cites W2272984102 @default.
• W2756213969 cites W2395068978 @default.
• W2756213969 cites W2409512767 @default.
• W2756213969 cites W2409753824 @default.
• W2756213969 cites W2412326719 @default.
• W2756213969 cites W2414296372 @default.
• W2756213969 cites W2462265227 @default.
• W2756213969 cites W2471631665 @default.
• W2756213969 cites W2496824200 @default.
• W2756213969 cites W2508488340 @default.
• W2756213969 cites W2508552393 @default.
• W2756213969 cites W2514783017 @default.
• W2756213969 cites W2517340812 @default.
• W2756213969 cites W2522622119 @default.
• W2756213969 cites W2591339118 @default.
• W2756213969 cites W271602275 @default.
• W2756213969 cites W2907642667 @default.
• W2756213969 cites W4250969231 @default.
• W2756213969 cites W4256179691 @default.
• W2756213969 cites W83646335 @default.
• W2756213969 doi "https://doi.org/10.18632/oncotarget.21097" @default.
• W2756213969 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5663576" @default.
• W2756213969 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29137404" @default.
• W2756213969 hasPublicationYear "2017" @default.
• W2756213969 type Work @default.
• W2756213969 sameAs 2756213969 @default.
• W2756213969 citedByCount "28" @default.
• W2756213969 countsByYear W27562139692018 @default.
• W2756213969 countsByYear W27562139692019 @default.
• W2756213969 countsByYear W27562139692020 @default.
• W2756213969 countsByYear W27562139692021 @default.
• W2756213969 countsByYear W27562139692022 @default.
• W2756213969 countsByYear W27562139692023 @default.
• W2756213969 crossrefType "journal-article" @default.
• W2756213969 hasAuthorship W2756213969A5005211285 @default.
• W2756213969 hasAuthorship W2756213969A5015696308 @default.
• W2756213969 hasAuthorship W2756213969A5017947601 @default.
• W2756213969 hasAuthorship W2756213969A5021249077 @default.
• W2756213969 hasAuthorship W2756213969A5029695887 @default.
• W2756213969 hasAuthorship W2756213969A5042636471 @default.
• W2756213969 hasAuthorship W2756213969A5048541371 @default.
• W2756213969 hasAuthorship W2756213969A5052095171 @default.
• W2756213969 hasAuthorship W2756213969A5075321325 @default.
• W2756213969 hasAuthorship W2756213969A5075517974 @default.

• next