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- W2756278614 abstract "Pseudomonas aeruginosa biofilms contribute to its survival on biotic and abiotic surfaces and represent a major clinical threat due to their high tolerance to antibiotics. Therefore, the discovery of antibiofilm agents may hold great promise. We show that pharmacological inhibition of the P. aeruginosa quorum-sensing regulator MvfR (PqsR) using a benzamide-benzimidazole compound interferes with biofilm formation and potentiates biofilm sensitivity to antibiotics. Such a strategy could have great potential against P. aeruginosa persistence in diverse environments." @default.
- W2756278614 created "2017-09-25" @default.
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- W2756278614 date "2017-12-01" @default.
- W2756278614 modified "2023-10-02" @default.
- W2756278614 title "Pharmacological Inhibition of the Pseudomonas aeruginosa MvfR Quorum-Sensing System Interferes with Biofilm Formation and Potentiates Antibiotic-Mediated Biofilm Disruption" @default.
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- W2756278614 doi "https://doi.org/10.1128/aac.01362-17" @default.
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