Matches in SemOpenAlex for { <https://semopenalex.org/work/W2756287248> ?p ?o ?g. }
- W2756287248 endingPage "R154" @default.
- W2756287248 startingPage "R141" @default.
- W2756287248 abstract "While in most patients with non-medullary thyroid cancer (TC), disease remission is achieved by thyroidectomy and ablation of tumor remnants by radioactive iodide (RAI), a substantial subgroup of patients with metastatic disease present tumor lesions that have acquired RAI resistance as a result of dedifferentiation. Although oncogenic mutations in BRAF, TERT promoter and TP53 are associated with an increased propensity for induction of dedifferentiation, the role of genetic and epigenetic aberrations and their effects on important intracellular signaling pathways is not yet fully elucidated. Also immune, metabolic, stemness and microRNA pathways have emerged as important determinants of TC dedifferentiation and RAI resistance. These signaling pathways have major clinical implications since their targeting could inhibit TC progression and could enable redifferentiation to restore RAI sensitivity. In this review, we discuss the current insights into the pathological processes conferring dedifferentiation and RAI resistance in TC and elaborate on novel advances in diagnostics and therapy to improve the clinical outcome of RAI-refractory TC patients." @default.
- W2756287248 created "2017-09-25" @default.
- W2756287248 creator A5003950067 @default.
- W2756287248 creator A5017111457 @default.
- W2756287248 creator A5052838073 @default.
- W2756287248 creator A5076475528 @default.
- W2756287248 creator A5083660817 @default.
- W2756287248 date "2017-11-01" @default.
- W2756287248 modified "2023-10-02" @default.
- W2756287248 title "Pathological processes and therapeutic advances in radioiodide refractory thyroid cancer" @default.
- W2756287248 cites W144423133 @default.
- W2756287248 cites W1548285582 @default.
- W2756287248 cites W1595948114 @default.
- W2756287248 cites W1774665921 @default.
- W2756287248 cites W1818250344 @default.
- W2756287248 cites W1848939527 @default.
- W2756287248 cites W1881802814 @default.
- W2756287248 cites W1898880890 @default.
- W2756287248 cites W1905017574 @default.
- W2756287248 cites W1948291609 @default.
- W2756287248 cites W1954381882 @default.
- W2756287248 cites W1965974095 @default.
- W2756287248 cites W1972629615 @default.
- W2756287248 cites W1972755526 @default.
- W2756287248 cites W1979387900 @default.
- W2756287248 cites W1981910764 @default.
- W2756287248 cites W1982518280 @default.
- W2756287248 cites W1984534129 @default.
- W2756287248 cites W1985124617 @default.
- W2756287248 cites W1985402095 @default.
- W2756287248 cites W1990347056 @default.
- W2756287248 cites W1997842432 @default.
- W2756287248 cites W1998990473 @default.
- W2756287248 cites W1999740972 @default.
- W2756287248 cites W2004465685 @default.
- W2756287248 cites W2005104363 @default.
- W2756287248 cites W2005678965 @default.
- W2756287248 cites W2006227733 @default.
- W2756287248 cites W2007264239 @default.
- W2756287248 cites W2010338407 @default.
- W2756287248 cites W2010868474 @default.
- W2756287248 cites W2014406863 @default.
- W2756287248 cites W2016403804 @default.
- W2756287248 cites W2017792949 @default.
- W2756287248 cites W2018168223 @default.
- W2756287248 cites W2019882992 @default.
- W2756287248 cites W2021222757 @default.
- W2756287248 cites W2021237871 @default.
- W2756287248 cites W2023354270 @default.
- W2756287248 cites W2023445598 @default.
- W2756287248 cites W2027475709 @default.
- W2756287248 cites W2028468396 @default.
- W2756287248 cites W2032386899 @default.
- W2756287248 cites W2032850628 @default.
- W2756287248 cites W2033735604 @default.
- W2756287248 cites W2035974695 @default.
- W2756287248 cites W2041125824 @default.
- W2756287248 cites W2042978536 @default.
- W2756287248 cites W2045882084 @default.
- W2756287248 cites W2046448885 @default.
- W2756287248 cites W2052289098 @default.
- W2756287248 cites W2054405945 @default.
- W2756287248 cites W2057867630 @default.
- W2756287248 cites W2058065101 @default.
- W2756287248 cites W2058350731 @default.
- W2756287248 cites W2058762974 @default.
- W2756287248 cites W2058908426 @default.
- W2756287248 cites W2062871120 @default.
- W2756287248 cites W2063632665 @default.
- W2756287248 cites W2065271250 @default.
- W2756287248 cites W2069792474 @default.
- W2756287248 cites W2070806796 @default.
- W2756287248 cites W2073183536 @default.
- W2756287248 cites W2076396609 @default.
- W2756287248 cites W2076411581 @default.
- W2756287248 cites W2077538477 @default.
- W2756287248 cites W2079466362 @default.
- W2756287248 cites W2080968920 @default.
- W2756287248 cites W2081057817 @default.
- W2756287248 cites W2082017108 @default.
- W2756287248 cites W2082972770 @default.
- W2756287248 cites W2091081560 @default.
- W2756287248 cites W2094326489 @default.
- W2756287248 cites W2094880719 @default.
- W2756287248 cites W2095667451 @default.
- W2756287248 cites W2095987251 @default.
- W2756287248 cites W2097038360 @default.
- W2756287248 cites W2097214275 @default.
- W2756287248 cites W2101606711 @default.
- W2756287248 cites W2102932249 @default.
- W2756287248 cites W2109379688 @default.
- W2756287248 cites W2111656898 @default.
- W2756287248 cites W2112988363 @default.
- W2756287248 cites W2113134419 @default.
- W2756287248 cites W2113307985 @default.
- W2756287248 cites W2113637323 @default.
- W2756287248 cites W2115103964 @default.
- W2756287248 cites W2115544910 @default.