Matches in SemOpenAlex for { <https://semopenalex.org/work/W2756312934> ?p ?o ?g. }
- W2756312934 abstract "At least 15 cases of human beings infected with H5N6 have been reported since 2014, of which at least 9 were fatal. The highly pathogenic avian H5N6 influenza virus may pose a serious threat to both public health and the poultry industry. However, the molecular features promoting the adaptation of avian H5N6 influenza viruses to mammalian hosts is not well understood. Here, we sequentially passaged an avian H5N6 influenza A virus (A/Northern Shoveler/Ningxia/488-53/2015) 10 times in mice to identify the adaptive amino acid substitutions that confer enhanced virulence to H5N6 in mammals. The first and tenth passages of the mouse-adapted H5N6 viruses were named P1 and P10 respectively. P1 and P10 displayed higher pathogenicity in mice than their parent strain. P10 showed significantly higher replication capability in vivo and could be detected in the brains of mice, whereas P1 displayed higher replication efficiency in their lungs but was not detectable in the brain. Similar to its parent strain, P10 remained no transmissible between guinea pigs. Using genome sequencing and alignment, multiple amino acid substitutions, including PB2 E627K, PB2 T23I, PA T97I and HA R239H, were found in the adaptation of H5N6 to mice. In summary, we identified amino acid changes that are associated with H5N6 adaptation to mice." @default.
- W2756312934 created "2017-09-25" @default.
- W2756312934 creator A5004930279 @default.
- W2756312934 creator A5005952555 @default.
- W2756312934 creator A5012817369 @default.
- W2756312934 creator A5013412405 @default.
- W2756312934 creator A5018323042 @default.
- W2756312934 creator A5023469580 @default.
- W2756312934 creator A5023940842 @default.
- W2756312934 creator A5027761006 @default.
- W2756312934 creator A5033993437 @default.
- W2756312934 creator A5038944035 @default.
- W2756312934 creator A5039991176 @default.
- W2756312934 creator A5044544424 @default.
- W2756312934 creator A5059972024 @default.
- W2756312934 creator A5064095838 @default.
- W2756312934 creator A5064581496 @default.
- W2756312934 creator A5080757739 @default.
- W2756312934 creator A5089195408 @default.
- W2756312934 date "2017-09-15" @default.
- W2756312934 modified "2023-10-16" @default.
- W2756312934 title "Amino Acid Substitutions Associated with Avian H5N6 Influenza A Virus Adaptation to Mice" @default.
- W2756312934 cites W1493636931 @default.
- W2756312934 cites W1868415946 @default.
- W2756312934 cites W1965490193 @default.
- W2756312934 cites W1970834790 @default.
- W2756312934 cites W1984006731 @default.
- W2756312934 cites W1986967706 @default.
- W2756312934 cites W1995045882 @default.
- W2756312934 cites W1996433534 @default.
- W2756312934 cites W2002010417 @default.
- W2756312934 cites W200323671 @default.
- W2756312934 cites W2009639157 @default.
- W2756312934 cites W2012463912 @default.
- W2756312934 cites W2017589835 @default.
- W2756312934 cites W2024684978 @default.
- W2756312934 cites W2029814807 @default.
- W2756312934 cites W2044728266 @default.
- W2756312934 cites W2049740179 @default.
- W2756312934 cites W2068738671 @default.
- W2756312934 cites W2072237100 @default.
- W2756312934 cites W2078626132 @default.
- W2756312934 cites W2078808862 @default.
- W2756312934 cites W2088127477 @default.
- W2756312934 cites W2092903823 @default.
- W2756312934 cites W2101094055 @default.
- W2756312934 cites W2106173155 @default.
- W2756312934 cites W2112170460 @default.
- W2756312934 cites W2113057965 @default.
- W2756312934 cites W2114585469 @default.
- W2756312934 cites W2121989894 @default.
- W2756312934 cites W2124521193 @default.
- W2756312934 cites W2133058176 @default.
- W2756312934 cites W2154970420 @default.
- W2756312934 cites W2158112812 @default.
- W2756312934 cites W2158989551 @default.
- W2756312934 cites W2159734253 @default.
- W2756312934 cites W2160782249 @default.
- W2756312934 cites W2165690966 @default.
- W2756312934 cites W2190422872 @default.
- W2756312934 cites W2216791516 @default.
- W2756312934 cites W2226982842 @default.
- W2756312934 cites W2275675851 @default.
- W2756312934 cites W2290758487 @default.
- W2756312934 cites W2302275630 @default.
- W2756312934 cites W2302544166 @default.
- W2756312934 cites W2309193730 @default.
- W2756312934 cites W2344669468 @default.
- W2756312934 cites W2591584396 @default.
- W2756312934 cites W3168314838 @default.
- W2756312934 doi "https://doi.org/10.3389/fmicb.2017.01763" @default.
- W2756312934 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5605651" @default.
- W2756312934 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28966609" @default.
- W2756312934 hasPublicationYear "2017" @default.
- W2756312934 type Work @default.
- W2756312934 sameAs 2756312934 @default.
- W2756312934 citedByCount "14" @default.
- W2756312934 countsByYear W27563129342018 @default.
- W2756312934 countsByYear W27563129342019 @default.
- W2756312934 countsByYear W27563129342020 @default.
- W2756312934 countsByYear W27563129342021 @default.
- W2756312934 countsByYear W27563129342022 @default.
- W2756312934 crossrefType "journal-article" @default.
- W2756312934 hasAuthorship W2756312934A5004930279 @default.
- W2756312934 hasAuthorship W2756312934A5005952555 @default.
- W2756312934 hasAuthorship W2756312934A5012817369 @default.
- W2756312934 hasAuthorship W2756312934A5013412405 @default.
- W2756312934 hasAuthorship W2756312934A5018323042 @default.
- W2756312934 hasAuthorship W2756312934A5023469580 @default.
- W2756312934 hasAuthorship W2756312934A5023940842 @default.
- W2756312934 hasAuthorship W2756312934A5027761006 @default.
- W2756312934 hasAuthorship W2756312934A5033993437 @default.
- W2756312934 hasAuthorship W2756312934A5038944035 @default.
- W2756312934 hasAuthorship W2756312934A5039991176 @default.
- W2756312934 hasAuthorship W2756312934A5044544424 @default.
- W2756312934 hasAuthorship W2756312934A5059972024 @default.
- W2756312934 hasAuthorship W2756312934A5064095838 @default.
- W2756312934 hasAuthorship W2756312934A5064581496 @default.
- W2756312934 hasAuthorship W2756312934A5080757739 @default.
- W2756312934 hasAuthorship W2756312934A5089195408 @default.