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• W2756335804 abstract "Abstract Shortly after intracerebral hemorrhage, neutrophils infiltrate the intracerebral hemorrhage-injured brain. Once within the brain, neutrophils degranulate, releasing destructive molecules that may exacerbate brain damage. However, neutrophils also release beneficial molecules, including iron-scavenging lactoferrin that may limit hematoma/iron-mediated brain injury after intracerebral hemorrhage. Here, we show that the immunoregulatory cytokine interleukin-27 is upregulated centrally and peripherally after intracerebral hemorrhage. Data from rodent models indicate that interleukin-27 modifies neutrophil maturation in the bone marrow, suppressing their production of pro-inflammatory/cytotoxic products while increasing their production of beneficial iron-scavenging molecules, including lactoferrin. Finally, interleukin-27 or lactoferrin administration results in reduced edema, enhanced hematoma clearance, and improved neurological outcomes in an animal model of intracerebral hemorrhage. These results suggest that interleukin-27/lactoferrin-mediated modulations of neutrophil function may represent a therapeutically viable concept for the modification of neutrophils toward a “beneficial” phenotype for the treatment of intracerebral hemorrhage." @default.
• W2756335804 created "2017-09-25" @default.
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• W2756335804 date "2017-09-19" @default.
• W2756335804 modified "2023-09-30" @default.
• W2756335804 title "Neutrophil polarization by IL-27 as a therapeutic target for intracerebral hemorrhage" @default.
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• W2756335804 doi "https://doi.org/10.1038/s41467-017-00770-7" @default.
• W2756335804 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5605643" @default.
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