Matches in SemOpenAlex for { <https://semopenalex.org/work/W2756423320> ?p ?o ?g. }
- W2756423320 endingPage "210" @default.
- W2756423320 startingPage "197" @default.
- W2756423320 abstract "A new series of pyridine derivatives with carbamic or amidic function has been designed and synthesized to act as cholinesterase inhibitors. The synthesized compounds were tested toward EeAChE and hAChE and toward eqBChE and hBChE. The carbamate 8 was the most potent hAChE inhibitor (IC50 = 0.153 ± 0.016 μM) while the carbamate 11 was the most potent inhibitor of hBChE (IC50 = 0.828 ± 0.067 μM). A molecular docking study indicated that the carbamate 8 was able to bind AChE by interacting with both CAS and PAS, in agreement with the mixed inhibition mechanism. Furthermore, the carbamates 8, 9 and 11 were able to inhibit Aβ42 self-aggregation and possessed quite low toxicity against human astrocytoma T67 and HeLa cell lines, being the carbamate 8 the less toxic compound on both cell lines." @default.
- W2756423320 created "2017-09-25" @default.
- W2756423320 creator A5005522171 @default.
- W2756423320 creator A5010541501 @default.
- W2756423320 creator A5017974202 @default.
- W2756423320 creator A5033627987 @default.
- W2756423320 creator A5040147173 @default.
- W2756423320 creator A5045870972 @default.
- W2756423320 creator A5057171579 @default.
- W2756423320 creator A5058536580 @default.
- W2756423320 creator A5064621591 @default.
- W2756423320 creator A5073685383 @default.
- W2756423320 creator A5074424627 @default.
- W2756423320 creator A5085206351 @default.
- W2756423320 date "2017-12-01" @default.
- W2756423320 modified "2023-10-03" @default.
- W2756423320 title "New pyridine derivatives as inhibitors of acetylcholinesterase and amyloid aggregation" @default.
- W2756423320 cites W1461736289 @default.
- W2756423320 cites W1885778179 @default.
- W2756423320 cites W1969661421 @default.
- W2756423320 cites W1971048984 @default.
- W2756423320 cites W1971513938 @default.
- W2756423320 cites W2001649679 @default.
- W2756423320 cites W2004863803 @default.
- W2756423320 cites W2016585694 @default.
- W2756423320 cites W2025022665 @default.
- W2756423320 cites W2025223727 @default.
- W2756423320 cites W2048718653 @default.
- W2756423320 cites W2049771698 @default.
- W2756423320 cites W2050456292 @default.
- W2756423320 cites W2051992129 @default.
- W2756423320 cites W2052606088 @default.
- W2756423320 cites W2054979333 @default.
- W2756423320 cites W2063553400 @default.
- W2756423320 cites W2070234396 @default.
- W2756423320 cites W2072688677 @default.
- W2756423320 cites W2075304800 @default.
- W2756423320 cites W2079749054 @default.
- W2756423320 cites W2085907924 @default.
- W2756423320 cites W2090156874 @default.
- W2756423320 cites W2090663532 @default.
- W2756423320 cites W2098437204 @default.
- W2756423320 cites W2100061207 @default.
- W2756423320 cites W2105668062 @default.
- W2756423320 cites W2112006614 @default.
- W2756423320 cites W2118512515 @default.
- W2756423320 cites W2130479394 @default.
- W2756423320 cites W2135732933 @default.
- W2756423320 cites W2137809729 @default.
- W2756423320 cites W2141003330 @default.
- W2756423320 cites W2206696478 @default.
- W2756423320 cites W2243097785 @default.
- W2756423320 cites W2323016000 @default.
- W2756423320 cites W2329336071 @default.
- W2756423320 cites W2337884630 @default.
- W2756423320 cites W2388623795 @default.
- W2756423320 cites W2401678552 @default.
- W2756423320 cites W2508443263 @default.
- W2756423320 cites W2513016555 @default.
- W2756423320 cites W2585258950 @default.
- W2756423320 cites W2593436234 @default.
- W2756423320 cites W4248650858 @default.
- W2756423320 cites W940731733 @default.
- W2756423320 doi "https://doi.org/10.1016/j.ejmech.2017.09.022" @default.
- W2756423320 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29031067" @default.
- W2756423320 hasPublicationYear "2017" @default.
- W2756423320 type Work @default.
- W2756423320 sameAs 2756423320 @default.
- W2756423320 citedByCount "30" @default.
- W2756423320 countsByYear W27564233202018 @default.
- W2756423320 countsByYear W27564233202019 @default.
- W2756423320 countsByYear W27564233202020 @default.
- W2756423320 countsByYear W27564233202021 @default.
- W2756423320 countsByYear W27564233202022 @default.
- W2756423320 countsByYear W27564233202023 @default.
- W2756423320 crossrefType "journal-article" @default.
- W2756423320 hasAuthorship W2756423320A5005522171 @default.
- W2756423320 hasAuthorship W2756423320A5010541501 @default.
- W2756423320 hasAuthorship W2756423320A5017974202 @default.
- W2756423320 hasAuthorship W2756423320A5033627987 @default.
- W2756423320 hasAuthorship W2756423320A5040147173 @default.
- W2756423320 hasAuthorship W2756423320A5045870972 @default.
- W2756423320 hasAuthorship W2756423320A5057171579 @default.
- W2756423320 hasAuthorship W2756423320A5058536580 @default.
- W2756423320 hasAuthorship W2756423320A5064621591 @default.
- W2756423320 hasAuthorship W2756423320A5073685383 @default.
- W2756423320 hasAuthorship W2756423320A5074424627 @default.
- W2756423320 hasAuthorship W2756423320A5085206351 @default.
- W2756423320 hasConcept C155647269 @default.
- W2756423320 hasConcept C159110408 @default.
- W2756423320 hasConcept C161176658 @default.
- W2756423320 hasConcept C181199279 @default.
- W2756423320 hasConcept C185592680 @default.
- W2756423320 hasConcept C202751555 @default.
- W2756423320 hasConcept C2776588719 @default.
- W2756423320 hasConcept C2776980637 @default.
- W2756423320 hasConcept C2777366897 @default.
- W2756423320 hasConcept C2777752497 @default.