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- W2756428131 abstract "Significance B cells produce antibodies in the context of immunoglobulin heavy chain (IgH) isotypes (e.g., IgM, IgG, and IgE). Each of these is generated either as secreted proteins or as membrane-bound B cell antigen receptors (BCRs). While much is known about how IgH isotype dictates effector function of soluble antibodies, the role of antibody isotype in the context of BCRs is not well defined. Here we demonstrate that the membrane-bound versions (mIg) of IgM, IgG1, and IgE are produced from their natural genomic loci in a hierarchal fashion, where mRNA transcripts for mIgM are always more dominant than mIgG1, which are always more dominant than mIgE, regardless of cell stage. These isotype-specific expression differences contribute to B cell regulation." @default.
- W2756428131 created "2017-09-25" @default.
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- W2756428131 date "2017-09-18" @default.
- W2756428131 modified "2023-09-27" @default.
- W2756428131 title "IgH isotype-specific B cell receptor expression influences B cell fate" @default.
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- W2756428131 doi "https://doi.org/10.1073/pnas.1704962114" @default.
- W2756428131 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5635877" @default.
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