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• W2756473472 abstract "Abstract Methanothermobacter thermoautotrophicus RNA ligase (MthRnl) catalyzes formation of phosphodiester bonds between the 5′-phosphate and 3′-hydroxyl termini of single-stranded RNAs. It can also react with RNA with a 3′-phosphate end to generate a 2′,3′-cyclic phosphate. Here, we show that MthRnl can additionally remove adenosine from the 3′-terminus of the RNA to produce 3′-deadenylated RNA, RNA(3′-rA). This 3′-deadenylation activity is metal-dependent and requires a 2′-hydroxyl at both the terminal adenosine and the penultimate nucleoside. Residues that contact the ATP/AMP in the MthRnl crystal structures are essential for the 3′-deadenylation activity, suggesting that 3′-adenosine may occupy the ATP-binding pocket. The 3′-end of cleaved RNA(3′-rA) consists of 2′,3′-cyclic phosphate which protects RNA(3′-rA) from ligation and further deadenylation. These findings suggest that ATP-dependent RNA ligase may act on a specific set of 3′-adenylated RNAs to regulate their processing and downstream biological events." @default.
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• W2756473472 date "2017-09-14" @default.
• W2756473472 modified "2023-09-23" @default.
• W2756473472 title "Cleavage of 3′-terminal adenosine by archaeal ATP-dependent RNA ligase" @default.
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• W2756473472 doi "https://doi.org/10.1038/s41598-017-11693-0" @default.
• W2756473472 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5599603" @default.
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