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• W2756479268 abstract "Regulatory approvals of non-vitamin K antagonist oral anticoagulants (NOACs) have been based on large randomized phase III trials evaluating dabigatran, rivaroxaban, apixaban, or edoxaban relative to warfarin for atrial fibrillation (AF). The results of the trials showed that all NOACs were at least non-inferior to warfarin in the prevention of stroke/thromboembolism and showed lower rates of intracranial bleeding than those associated with warfarin. However, the trials were designed differently, varied in the inclusion/exclusion criteria, and used either one dose or a low/high dose of the NOAC drug. Some of these differences have challenged the ability to directly compare various NOACs, and comparative data on effectiveness and intracranial bleeding are sparse in real-world patients. Real-world data complement data from large randomized phase III trials by providing new aspects of the real-world absolute risks of ischemic and hemorrhagic stroke associated with NOACs vs. warfarin. Moreover, real-world fragile patients might have been included (e.g., patients with increased risk of bleeding, liver disease, and chronic kidney disease), although these patients would be less represented in trials. This paper introduces recently published real-world data of NOACs and further suggests the recommended dosage of NOACs for Korean patients." @default.
• W2756479268 created "2017-09-25" @default.
• W2756479268 creator A5050000016 @default.
• W2756479268 date "2017-01-01" @default.
• W2756479268 modified "2023-10-08" @default.
• W2756479268 title "Real-world Data and Recommended Dosage of Non-vitamin K Oral Anticoagulants for Korean Patients" @default.
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• W2756479268 doi "https://doi.org/10.4070/kcj.2017.0158" @default.
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