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- W2756551391 endingPage "2841" @default.
- W2756551391 startingPage "2827" @default.
- W2756551391 abstract "Peptidomimetics are designed to overcome the poor pharmacokinetics and pharmacodynamics associated with the native peptide or protein on which they are based. The design of peptidomimetics starts from developing structure-activity relationships of the native ligand-target pair that identify the key residues that are responsible for the biological effect of the native peptide or protein. Then minimization of the structure and introduction of constraints are applied to create the core active site that can interact with the target with high affinity and selectivity. Developing peptidomimetics is not trivial and often challenging, particularly when peptides’ interaction mechanism with their target is complex. This review will discuss the challenges of developing peptidomimetics of therapeutically important insulin superfamily peptides, particularly those which have two chains (A and B) and three disulfide bonds and whose receptors are known, namely insulin, H2 relaxin, H3 relaxin, INSL3 and INSL5." @default.
- W2756551391 created "2017-10-06" @default.
- W2756551391 creator A5018221908 @default.
- W2756551391 creator A5074997845 @default.
- W2756551391 date "2018-06-01" @default.
- W2756551391 modified "2023-10-14" @default.
- W2756551391 title "Challenges in the design of insulin and relaxin/insulin-like peptide mimetics" @default.
- W2756551391 cites W1493960655 @default.
- W2756551391 cites W1541126533 @default.
- W2756551391 cites W1558343075 @default.
- W2756551391 cites W1582598840 @default.
- W2756551391 cites W1604799242 @default.
- W2756551391 cites W1618131473 @default.
- W2756551391 cites W1629887654 @default.
- W2756551391 cites W1928593782 @default.
- W2756551391 cites W1963765655 @default.
- W2756551391 cites W1972255380 @default.
- W2756551391 cites W1973126024 @default.
- W2756551391 cites W1980391151 @default.
- W2756551391 cites W1982011995 @default.
- W2756551391 cites W1982601346 @default.
- W2756551391 cites W1988550226 @default.
- W2756551391 cites W1994025914 @default.
- W2756551391 cites W1994563972 @default.
- W2756551391 cites W1996038926 @default.
- W2756551391 cites W2004948333 @default.
- W2756551391 cites W2005341199 @default.
- W2756551391 cites W2006535096 @default.
- W2756551391 cites W2008460438 @default.
- W2756551391 cites W2008914799 @default.
- W2756551391 cites W2010951756 @default.
- W2756551391 cites W2011403383 @default.
- W2756551391 cites W2011484548 @default.
- W2756551391 cites W2011534006 @default.
- W2756551391 cites W2012486233 @default.
- W2756551391 cites W2014908362 @default.
- W2756551391 cites W2015622749 @default.
- W2756551391 cites W2022963354 @default.
- W2756551391 cites W2028638910 @default.
- W2756551391 cites W2029561421 @default.
- W2756551391 cites W2029837745 @default.
- W2756551391 cites W2031450195 @default.
- W2756551391 cites W2037326883 @default.
- W2756551391 cites W2042085117 @default.
- W2756551391 cites W2044435842 @default.
- W2756551391 cites W2044987386 @default.
- W2756551391 cites W2045171671 @default.
- W2756551391 cites W2049155275 @default.
- W2756551391 cites W2053208884 @default.
- W2756551391 cites W2054625944 @default.
- W2756551391 cites W2057237455 @default.
- W2756551391 cites W2057584812 @default.
- W2756551391 cites W2057916223 @default.
- W2756551391 cites W2061073198 @default.
- W2756551391 cites W2066926591 @default.
- W2756551391 cites W2068583404 @default.
- W2756551391 cites W2074096613 @default.
- W2756551391 cites W2077630059 @default.
- W2756551391 cites W2079659159 @default.
- W2756551391 cites W2079976640 @default.
- W2756551391 cites W2082818407 @default.
- W2756551391 cites W2083891358 @default.
- W2756551391 cites W2085466569 @default.
- W2756551391 cites W2085522770 @default.
- W2756551391 cites W2089225173 @default.
- W2756551391 cites W2089395418 @default.
- W2756551391 cites W2092817365 @default.
- W2756551391 cites W2093995323 @default.
- W2756551391 cites W2094355220 @default.
- W2756551391 cites W2094898273 @default.
- W2756551391 cites W2095720053 @default.
- W2756551391 cites W2099637800 @default.
- W2756551391 cites W2120609024 @default.
- W2756551391 cites W2122220681 @default.
- W2756551391 cites W2122640362 @default.
- W2756551391 cites W2125021972 @default.
- W2756551391 cites W2125218472 @default.
- W2756551391 cites W2125686850 @default.
- W2756551391 cites W2125873842 @default.
- W2756551391 cites W2130157485 @default.
- W2756551391 cites W2131874815 @default.
- W2756551391 cites W2132468662 @default.
- W2756551391 cites W2135932371 @default.
- W2756551391 cites W2144133200 @default.
- W2756551391 cites W2148213185 @default.
- W2756551391 cites W2156043999 @default.
- W2756551391 cites W2158779441 @default.
- W2756551391 cites W2160162119 @default.
- W2756551391 cites W2163443807 @default.
- W2756551391 cites W2186857416 @default.
- W2756551391 cites W2195165230 @default.
- W2756551391 cites W2258765176 @default.
- W2756551391 cites W2275420596 @default.
- W2756551391 cites W2328587896 @default.
- W2756551391 cites W2329540785 @default.
- W2756551391 cites W2337688087 @default.
- W2756551391 cites W2411269977 @default.
- W2756551391 cites W2466876597 @default.