FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2756739497> ?p ?o ?g. }

• W2756739497 endingPage "390" @default.
• W2756739497 startingPage "377" @default.
• W2756739497 abstract "We assessed in rainbow trout hypothalamus the effects of oleate and octanoate on levels and phosphorylation status of two transcription factors, FoxO1 and CREB, possibly involved in linking activation of fatty acid sensing with modulation of food intake through the expression of brain neuropeptides. Moreover, we assessed changes in the phosphorylation status of three proteins possibly involved in modulation of these transcription factors such as Akt, AMPK and mTOR. In a first experiment, we evaluated, in pools of hypothalamus incubated for 3 h and 6 h at 15°C in a modified Hanks' medium containing 100 or 500 µM oleate or octanoate, the response of fatty acid sensing, neuropeptide expression and phosphorylation status of proteins of interest. The activation of fatty acid sensing and enhanced anorectic potential occurred in parallel with the activation of Akt and mTOR, and the inhibition of AMPK. The changes in these proteins would relate to a neuropeptide expression through changes in the phosphorylation status of transcription factors under their control, such as CREB and FoxO1, which displayed inhibitory (CREB) or activatory (FoxO1) responses when tissues were incubated with oleate or octanoate. In a second experiment, we incubated hypothalamus for 6 h with 500 µM oleate or octanoate alone or in the presence of specific inhibitors of Akt, AMPK, mTOR, CREB or FoxO1. The presence of inhibitors counteracted the effects of oleate or octanoate on the phosphorylation status of the proteins of interest. The results support, for the first time in fish, the involvement of these proteins in the regulation of food intake by fatty acids." @default.
• W2756739497 created "2017-10-06" @default.
• W2756739497 creator A5003458745 @default.
• W2756739497 creator A5027259950 @default.
• W2756739497 creator A5028232531 @default.
• W2756739497 creator A5049610984 @default.
• W2756739497 creator A5085854644 @default.
• W2756739497 date "2017-11-01" @default.
• W2756739497 modified "2023-09-25" @default.
• W2756739497 title "Hypothalamic mechanisms linking fatty acid sensing and food intake regulation in rainbow trout" @default.
• W2756739497 cites W1898069917 @default.
• W2756739497 cites W1966656674 @default.
• W2756739497 cites W1979221306 @default.
• W2756739497 cites W1981476435 @default.
• W2756739497 cites W1983769105 @default.
• W2756739497 cites W1988271479 @default.
• W2756739497 cites W1991538201 @default.
• W2756739497 cites W2001582606 @default.
• W2756739497 cites W2001938126 @default.
• W2756739497 cites W2008521544 @default.
• W2756739497 cites W2018142889 @default.
• W2756739497 cites W2018173789 @default.
• W2756739497 cites W2020843850 @default.
• W2756739497 cites W2023897687 @default.
• W2756739497 cites W2025544481 @default.
• W2756739497 cites W2026453375 @default.
• W2756739497 cites W2028759854 @default.
• W2756739497 cites W2029236887 @default.
• W2756739497 cites W2031707524 @default.
• W2756739497 cites W2037281310 @default.
• W2756739497 cites W2040352209 @default.
• W2756739497 cites W2043360187 @default.
• W2756739497 cites W2046822015 @default.
• W2756739497 cites W2047463859 @default.
• W2756739497 cites W2047881215 @default.
• W2756739497 cites W2051651213 @default.
• W2756739497 cites W2055816492 @default.
• W2756739497 cites W2057522783 @default.
• W2756739497 cites W2061363738 @default.
• W2756739497 cites W2065699540 @default.
• W2756739497 cites W2071470362 @default.
• W2756739497 cites W2089614570 @default.
• W2756739497 cites W2103544863 @default.
• W2756739497 cites W2108244474 @default.
• W2756739497 cites W2108953612 @default.
• W2756739497 cites W2111786745 @default.
• W2756739497 cites W2114987462 @default.
• W2756739497 cites W2115622142 @default.
• W2756739497 cites W2116349390 @default.
• W2756739497 cites W2121147154 @default.
• W2756739497 cites W2129578178 @default.
• W2756739497 cites W2131877042 @default.
• W2756739497 cites W2132216130 @default.
• W2756739497 cites W2147044753 @default.
• W2756739497 cites W2147558102 @default.
• W2756739497 cites W2150951457 @default.
• W2756739497 cites W2158423099 @default.
• W2756739497 cites W2175432880 @default.
• W2756739497 cites W2209171875 @default.
• W2756739497 cites W2215696800 @default.
• W2756739497 cites W2231620107 @default.
• W2756739497 cites W2278628422 @default.
• W2756739497 cites W2287666408 @default.
• W2756739497 cites W2312478865 @default.
• W2756739497 cites W2494179852 @default.
• W2756739497 cites W2551180509 @default.
• W2756739497 cites W2567489957 @default.
• W2756739497 cites W2570292657 @default.
• W2756739497 cites W2590195408 @default.
• W2756739497 cites W2604689206 @default.
• W2756739497 cites W2613514757 @default.
• W2756739497 cites W2666662410 @default.
• W2756739497 doi "https://doi.org/10.1530/jme-17-0148" @default.
• W2756739497 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28951437" @default.
• W2756739497 hasPublicationYear "2017" @default.
• W2756739497 type Work @default.
• W2756739497 sameAs 2756739497 @default.
• W2756739497 citedByCount "20" @default.
• W2756739497 countsByYear W27567394972018 @default.
• W2756739497 countsByYear W27567394972019 @default.
• W2756739497 countsByYear W27567394972020 @default.
• W2756739497 countsByYear W27567394972021 @default.
• W2756739497 countsByYear W27567394972022 @default.
• W2756739497 countsByYear W27567394972023 @default.
• W2756739497 crossrefType "journal-article" @default.
• W2756739497 hasAuthorship W2756739497A5003458745 @default.
• W2756739497 hasAuthorship W2756739497A5027259950 @default.
• W2756739497 hasAuthorship W2756739497A5028232531 @default.
• W2756739497 hasAuthorship W2756739497A5049610984 @default.
• W2756739497 hasAuthorship W2756739497A5085854644 @default.
• W2756739497 hasBestOaLocation W27567394971 @default.
• W2756739497 hasConcept C104317684 @default.
• W2756739497 hasConcept C11960822 @default.
• W2756739497 hasConcept C126322002 @default.
• W2756739497 hasConcept C134018914 @default.
• W2756739497 hasConcept C140149449 @default.
• W2756739497 hasConcept C1629964 @default.
• W2756739497 hasConcept C185592680 @default.

• next