Matches in SemOpenAlex for { <https://semopenalex.org/work/W2756804923> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2756804923 endingPage "1266" @default.
- W2756804923 startingPage "1260" @default.
- W2756804923 abstract "Cinnamaldehyde (CA), the primary chemical component of the Chinese traditional herb Cinnamomum cassia, is an effective cytotoxic agent against various human cancers. Our previous study indicated that CA could trigger apoptosis in three kinds of non-small cell lung cancer (NSCLC) cells. However, CA mechanism of action in NSCLC has not been unveiled completely. Herein, we showed that a novel circular RNA hsa_circ_0043256 was upregulated in NSCLC cells in response to CA treatment, as detected by microarray and real-time PCR. Hsa_circ_0043256 could inhibit cell proliferation and induce apoptosis, while hsa_circ_0043256 knock-down could promote cell proliferation and restrain apoptosis induced by CA. Bioinformatics analysis predicted that hsa_circ_0043256 could work as a miR-1252 sponge, which could in turn directly target a vital negative regulator of Canonical Wnt signaling, Itchy E3 ubiquitin protein ligase (ITCH), as validated by dual-luciferase assay. Western blot results further confirmed that hsa_circ_0043256 could upregulate ITCH expression, whereas miR-1252 could partially abolish this effect. Interestingly, hsa_circ_0043256 knock-down could weaken Wnt/β-catenin pathway inhibition induced by CA. Finally, we discovered that CA induced apoptosis and meanwhile upregulated hsa_circ_0043256 expression in vivo. Immunohistochemical analysis revealed that ITCH expression was positively association with hsa_circ_0043256 levels. Above all, we characterized a new mechanism mediated by hsa_circ_0043256/miR-1252/ITCH axis in CA function against NSCLC, providing a novel insight into lung cancer therapy." @default.
- W2756804923 created "2017-10-06" @default.
- W2756804923 creator A5003820242 @default.
- W2756804923 creator A5032209186 @default.
- W2756804923 creator A5071143477 @default.
- W2756804923 creator A5075189232 @default.
- W2756804923 date "2017-11-01" @default.
- W2756804923 modified "2023-10-11" @default.
- W2756804923 title "Cinnamaldehyde induces cell apoptosis mediated by a novel circular RNA hsa_circ_0043256 in non-small cell lung cancer" @default.
- W2756804923 cites W1032731786 @default.
- W2756804923 cites W1874402154 @default.
- W2756804923 cites W1985656532 @default.
- W2756804923 cites W1997671728 @default.
- W2756804923 cites W1998621966 @default.
- W2756804923 cites W2005440429 @default.
- W2756804923 cites W2058835062 @default.
- W2756804923 cites W2060940710 @default.
- W2756804923 cites W2064165694 @default.
- W2756804923 cites W2083485087 @default.
- W2756804923 cites W2137691989 @default.
- W2756804923 cites W2150964566 @default.
- W2756804923 cites W2172312226 @default.
- W2756804923 cites W2308368972 @default.
- W2756804923 cites W2340502580 @default.
- W2756804923 cites W2517463990 @default.
- W2756804923 cites W2523076424 @default.
- W2756804923 cites W2576627022 @default.
- W2756804923 cites W2618790508 @default.
- W2756804923 cites W2726649874 @default.
- W2756804923 cites W2744268790 @default.
- W2756804923 cites W299875771 @default.
- W2756804923 cites W2105124365 @default.
- W2756804923 doi "https://doi.org/10.1016/j.bbrc.2017.09.136" @default.
- W2756804923 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28958934" @default.
- W2756804923 hasPublicationYear "2017" @default.
- W2756804923 type Work @default.
- W2756804923 sameAs 2756804923 @default.
- W2756804923 citedByCount "84" @default.
- W2756804923 countsByYear W27568049232018 @default.
- W2756804923 countsByYear W27568049232019 @default.
- W2756804923 countsByYear W27568049232020 @default.
- W2756804923 countsByYear W27568049232021 @default.
- W2756804923 countsByYear W27568049232022 @default.
- W2756804923 countsByYear W27568049232023 @default.
- W2756804923 crossrefType "journal-article" @default.
- W2756804923 hasAuthorship W2756804923A5003820242 @default.
- W2756804923 hasAuthorship W2756804923A5032209186 @default.
- W2756804923 hasAuthorship W2756804923A5071143477 @default.
- W2756804923 hasAuthorship W2756804923A5075189232 @default.
- W2756804923 hasConcept C104317684 @default.
- W2756804923 hasConcept C127561419 @default.
- W2756804923 hasConcept C137620995 @default.
- W2756804923 hasConcept C153911025 @default.
- W2756804923 hasConcept C185592680 @default.
- W2756804923 hasConcept C190283241 @default.
- W2756804923 hasConcept C2776415932 @default.
- W2756804923 hasConcept C502942594 @default.
- W2756804923 hasConcept C55493867 @default.
- W2756804923 hasConcept C62112901 @default.
- W2756804923 hasConcept C62478195 @default.
- W2756804923 hasConcept C86803240 @default.
- W2756804923 hasConcept C95444343 @default.
- W2756804923 hasConceptScore W2756804923C104317684 @default.
- W2756804923 hasConceptScore W2756804923C127561419 @default.
- W2756804923 hasConceptScore W2756804923C137620995 @default.
- W2756804923 hasConceptScore W2756804923C153911025 @default.
- W2756804923 hasConceptScore W2756804923C185592680 @default.
- W2756804923 hasConceptScore W2756804923C190283241 @default.
- W2756804923 hasConceptScore W2756804923C2776415932 @default.
- W2756804923 hasConceptScore W2756804923C502942594 @default.
- W2756804923 hasConceptScore W2756804923C55493867 @default.
- W2756804923 hasConceptScore W2756804923C62112901 @default.
- W2756804923 hasConceptScore W2756804923C62478195 @default.
- W2756804923 hasConceptScore W2756804923C86803240 @default.
- W2756804923 hasConceptScore W2756804923C95444343 @default.
- W2756804923 hasFunder F4320325434 @default.
- W2756804923 hasIssue "3" @default.
- W2756804923 hasLocation W27568049231 @default.
- W2756804923 hasOpenAccess W2756804923 @default.
- W2756804923 hasPrimaryLocation W27568049231 @default.
- W2756804923 hasRelatedWork W2055808176 @default.
- W2756804923 hasRelatedWork W2080599553 @default.
- W2756804923 hasRelatedWork W2165132828 @default.
- W2756804923 hasRelatedWork W2365516742 @default.
- W2756804923 hasRelatedWork W2507081987 @default.
- W2756804923 hasRelatedWork W2543202296 @default.
- W2756804923 hasRelatedWork W2592007767 @default.
- W2756804923 hasRelatedWork W2937181318 @default.
- W2756804923 hasRelatedWork W3016435787 @default.
- W2756804923 hasRelatedWork W3148046299 @default.
- W2756804923 hasVolume "493" @default.
- W2756804923 isParatext "false" @default.
- W2756804923 isRetracted "false" @default.
- W2756804923 magId "2756804923" @default.
- W2756804923 workType "article" @default.