Matches in SemOpenAlex for { <https://semopenalex.org/work/W2756856565> ?p ?o ?g. }
- W2756856565 endingPage "302" @default.
- W2756856565 startingPage "259" @default.
- W2756856565 abstract "In vitro and in vivo experimental models clearly demonstrate the efficacy of Se compounds as anticancer agents, contingent upon chemical structures and concentrations of test molecules, as well as on the experimental model under investigation that together influence cellular availability of compounds, their molecular dynamics and mechanism of action. The latter includes direct and indirect redox effects on cellular targets by the activation and altered compartmentalization of molecular oxygen, and the interaction with protein thiols and Se proteins. As such, Se compounds interfere with the redox homeostasis and signaling of cancer cells to produce anticancer effects that include alterations in key regulatory elements of energy metabolism and cell cycle checkpoints that ultimately influence differentiation, proliferation, senescence, and death pathways. Cys-containing proteins and Se proteins involved in the response to Se compounds as sensors and transducers of anticancer signals, i.e., the pharmacoproteome of Se compounds, are described and include critical elements in the different phases of cancer onset and progression from initiation and escape of immune surveillance to tumor growth, angiogenesis, and metastasis. The efficacy and mode of action on these compounds vary depending on the inorganic and organic form of Se used as either supplement or pharmacological agent. In this regard, differences in experimental/clinical protocols provide options for either chemoprevention or therapy in different human cancers." @default.
- W2756856565 created "2017-10-06" @default.
- W2756856565 creator A5016797870 @default.
- W2756856565 creator A5018523532 @default.
- W2756856565 creator A5041279745 @default.
- W2756856565 creator A5057411721 @default.
- W2756856565 creator A5068656271 @default.
- W2756856565 creator A5073889564 @default.
- W2756856565 creator A5073926538 @default.
- W2756856565 creator A5077975100 @default.
- W2756856565 date "2017-01-01" @default.
- W2756856565 modified "2023-10-13" @default.
- W2756856565 title "Selenocompounds in Cancer Therapy: An Overview" @default.
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