Matches in SemOpenAlex for { <https://semopenalex.org/work/W2756958729> ?p ?o ?g. }
- W2756958729 endingPage "179" @default.
- W2756958729 startingPage "171" @default.
- W2756958729 abstract "As documented in a Vietnamese traditional medical encyclopedia, Syzygium formosum (Wall.) Masam leaves have been routinely used among indigenous Vietnamese people for treatment of various allergy-like symptoms including dermatitis and rhinitis. Anti-allergic activity of S. formosum leaves was examined with a mouse model of chicken ovalbumin (cOVA)-induced food allergy, and mechanisms underlying the anti-allergic effect were explored. BALB/c mice were administered i.p. cOVA (20 μg) plus alum (2 mg) twice on day 0 and 14 for sensitization (immunization). Two weeks after the second immunization, the mice were administered cOVA (50 mg) p.o. 5 times every 3 days to induce food allergy symptoms (i.e., anaphylaxis, diarrhea, and drop in the body temperature). Ethanol extract of dried leaves of S. formosum (80 mg/kg or 200 mg/kg body weight) was administered p.o. daily during the induction (challenge) period. Treatment with the S. formosum leaves ethanol extract ameliorated the allergic symptoms to a significant extent and in a dose-dependent manner. The treatment also resulted in a significant improvement in the inflammatory lesion in the small intestine and reduction in the numbers of mast cells and eosinophils recruited to the lesion. The treatment also brought about a significant reduction in the levels of Th2 cytokines produced by the mesenteric lymph node cells cultured ex vivo with cOVA. The passive anaphylaxis experiment also showed that the extract treatment impaired the mast cell function. Our study provides a scientific basis for the traditional (indigenous) use of the S. formosum leaves extract for the treatment of various allergy symptoms in Vietnam. In addition, the results show that the extract has activities to suppress antigen-specific Th2 T cell immune responses and the mast cell function, which are directly related with its anti-allergic effect." @default.
- W2756958729 created "2017-10-06" @default.
- W2756958729 creator A5011861620 @default.
- W2756958729 creator A5033369273 @default.
- W2756958729 creator A5046356564 @default.
- W2756958729 creator A5049755995 @default.
- W2756958729 creator A5054893659 @default.
- W2756958729 creator A5059137426 @default.
- W2756958729 creator A5072490462 @default.
- W2756958729 date "2018-01-01" @default.
- W2756958729 modified "2023-10-10" @default.
- W2756958729 title "Anti-allergic effects of the ethanol extract of Syzygium formosum (Wall.) Masam leaves and its immunoregulatory mechanisms" @default.
- W2756958729 cites W1212048369 @default.
- W2756958729 cites W1526272313 @default.
- W2756958729 cites W1566553022 @default.
- W2756958729 cites W1674201197 @default.
- W2756958729 cites W1977953521 @default.
- W2756958729 cites W1981034102 @default.
- W2756958729 cites W1986985221 @default.
- W2756958729 cites W1991354178 @default.
- W2756958729 cites W1994163770 @default.
- W2756958729 cites W2002156365 @default.
- W2756958729 cites W2015800485 @default.
- W2756958729 cites W2016091796 @default.
- W2756958729 cites W2026041959 @default.
- W2756958729 cites W2028190708 @default.
- W2756958729 cites W2030633414 @default.
- W2756958729 cites W2048591508 @default.
- W2756958729 cites W2062498772 @default.
- W2756958729 cites W2085229905 @default.
- W2756958729 cites W2088368924 @default.
- W2756958729 cites W2091744938 @default.
- W2756958729 cites W2113518618 @default.
- W2756958729 cites W2113635597 @default.
- W2756958729 cites W2128104166 @default.
- W2756958729 cites W2135536194 @default.
- W2756958729 cites W2147172644 @default.
- W2756958729 cites W2151978148 @default.
- W2756958729 cites W2153292496 @default.
- W2756958729 cites W2165096856 @default.
- W2756958729 cites W2254633975 @default.
- W2756958729 cites W2322166104 @default.
- W2756958729 cites W2545836320 @default.
- W2756958729 cites W2571299797 @default.
- W2756958729 cites W2591013809 @default.
- W2756958729 cites W3022011172 @default.
- W2756958729 cites W4244649778 @default.
- W2756958729 doi "https://doi.org/10.1016/j.jep.2017.09.026" @default.
- W2756958729 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28943447" @default.
- W2756958729 hasPublicationYear "2018" @default.
- W2756958729 type Work @default.
- W2756958729 sameAs 2756958729 @default.
- W2756958729 citedByCount "11" @default.
- W2756958729 countsByYear W27569587292018 @default.
- W2756958729 countsByYear W27569587292019 @default.
- W2756958729 countsByYear W27569587292020 @default.
- W2756958729 countsByYear W27569587292021 @default.
- W2756958729 countsByYear W27569587292022 @default.
- W2756958729 countsByYear W27569587292023 @default.
- W2756958729 crossrefType "journal-article" @default.
- W2756958729 hasAuthorship W2756958729A5011861620 @default.
- W2756958729 hasAuthorship W2756958729A5033369273 @default.
- W2756958729 hasAuthorship W2756958729A5046356564 @default.
- W2756958729 hasAuthorship W2756958729A5049755995 @default.
- W2756958729 hasAuthorship W2756958729A5054893659 @default.
- W2756958729 hasAuthorship W2756958729A5059137426 @default.
- W2756958729 hasAuthorship W2756958729A5072490462 @default.
- W2756958729 hasConcept C142724271 @default.
- W2756958729 hasConcept C203014093 @default.
- W2756958729 hasConcept C204787440 @default.
- W2756958729 hasConcept C207480886 @default.
- W2756958729 hasConcept C2775933838 @default.
- W2756958729 hasConcept C2776027960 @default.
- W2756958729 hasConcept C2776946954 @default.
- W2756958729 hasConcept C2779969877 @default.
- W2756958729 hasConcept C71924100 @default.
- W2756958729 hasConcept C8891405 @default.
- W2756958729 hasConceptScore W2756958729C142724271 @default.
- W2756958729 hasConceptScore W2756958729C203014093 @default.
- W2756958729 hasConceptScore W2756958729C204787440 @default.
- W2756958729 hasConceptScore W2756958729C207480886 @default.
- W2756958729 hasConceptScore W2756958729C2775933838 @default.
- W2756958729 hasConceptScore W2756958729C2776027960 @default.
- W2756958729 hasConceptScore W2756958729C2776946954 @default.
- W2756958729 hasConceptScore W2756958729C2779969877 @default.
- W2756958729 hasConceptScore W2756958729C71924100 @default.
- W2756958729 hasConceptScore W2756958729C8891405 @default.
- W2756958729 hasFunder F4320322120 @default.
- W2756958729 hasFunder F4320334884 @default.
- W2756958729 hasLocation W27569587291 @default.
- W2756958729 hasLocation W27569587292 @default.
- W2756958729 hasOpenAccess W2756958729 @default.
- W2756958729 hasPrimaryLocation W27569587291 @default.
- W2756958729 hasRelatedWork W1659709475 @default.
- W2756958729 hasRelatedWork W1991051084 @default.
- W2756958729 hasRelatedWork W2030302831 @default.
- W2756958729 hasRelatedWork W2130339011 @default.
- W2756958729 hasRelatedWork W2148653709 @default.