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- W2756976466 abstract "Abstract Mediating the expansion of vascular beds in many physiological and pathological settings, angiogenesis requires dynamic changes in endothelial cell behavior. However, the molecular mechanisms governing endothelial cell activity during different phases of vascular growth, remodeling, maturation, and quiescence remain elusive. Here, we characterize dynamic gene expression changes during postnatal development and identify critical angiogenic factors in mouse retinal endothelial cells. Using actively translating transcriptome analysis and in silico computational analyses, we determine candidate regulators controlling endothelial cell behavior at different developmental stages. We further show that one of the identified candidates, the transcription factor MafB, controls endothelial sprouting in vitro and in vivo, and perform an integrative analysis of RNA-Seq and ChIP-Seq data to define putative direct MafB targets, which are activated or repressed by the transcriptional regulator. Together, our results identify novel cell-autonomous regulatory mechanisms controlling sprouting angiogenesis." @default.
- W2756976466 created "2017-10-06" @default.
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- W2756976466 date "2017-09-28" @default.
- W2756976466 modified "2023-10-17" @default.
- W2756976466 title "Transcriptional regulation of endothelial cell behavior during sprouting angiogenesis" @default.
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- W2756976466 doi "https://doi.org/10.1038/s41467-017-00738-7" @default.
- W2756976466 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5620061" @default.
- W2756976466 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28959057" @default.
- W2756976466 hasPublicationYear "2017" @default.
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